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Glioblastoma in a patient with tuberous sclerosis

Author:
Azriel, Amit  Gogos, Andrew  Rogers, TeWhiti  Moscovici, Samuel  Lo, Patrick  Drummond, Katharine  


Journal:
JOURNAL OF CLINICAL NEUROSCIENCE


Issue Date:
2019


Abstract(summary):

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder with a wide clinical spectrum. The most common brain tumor associated with TSC is the low grade subependymal giant cell astrocytoma. Reports of high grade primary brain tumors in patients with TSC are rare. TSC1/2 mutation has been identified in glioblastoma (GBM) even though it probably does not increase the overall risk for GBM in patients with TSC. We present a 58-year-old patient with known TSC, admitted for new neurological symptoms, diagnosed with a large heterogeneous tumor involving most of the corpus callosum. Stereotactic needle brain biopsy confirmed the diagnosis to be GBM. Five previously reported similar cases are reviewed, reflecting diversity in clinical and radiological findings and indicating that a high index of clinical suspicion must be maintained in patients with TSC. (C) 2018 Elsevier Ltd. All rights reserved.


Page:
153---155


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