Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin

Author:

María Eugenia Chamorro  Romina Eugenia Maltaneri  Daniela Cecilia Vittori  Alcira Beatriz Nesse  

Journal:

The International Journal of Biochemistry & Cell Biology

Issue Date:

2015

Abstract(summary):

Highlights • Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells. • cEpo induced only transient phosphorylation of proliferative pathways. • PTP1B activity was significantly increased in cultures with cEpo. • PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo. • Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.

Page:

63-63