Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells

Author:

Namekata, Iyuki   Tsuruoka, Noriko   Tsuneoka, Yayoi   Matsuda, Tomoyuki   Takahara, Akira   Tanaka, Yoshio   Suzuki, Takeshi   Takahashi, Tetsuo   Iida-Tanaka, Naoko   Tanaka, Hikaru  

Journal:

Biological & Pharmaceutical Bulletin

Issue Date:

2011

Abstract(summary):

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (I(Ks)) NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC(50) value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 mu M and 4.9 mu M, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

Page:

153-155