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New structural and functional insight into the regulation of Ras

Author:
Kano, Yoshihito   Cook, Jonathan D.   Lee, Jeffrey E.   Ohh, Michael  


Journal:
Seminars in Cell & Developmental Biology


Issue Date:
2016


Abstract(summary):

Mutations in RAS and various components of the Ras signaling pathways are among the most common causative genetic alterations in human cancers, accounting up to 25% of lung cancers and over 90% of pancreatic cancers. Ras is a small GTPase that functions as a ‘molecular switch’ in a number of signaling pathways that regulate vital eukaryotic cellular functions. Despite our comprehensive understanding of the molecular mechanisms governing the activity of Ras, the clinical outcome of various pharmacologic anti-cancer strategies designed to directly inactivate Ras have been less than satisfactory. In this review, the more recently uncovered mode of regulation of Ras involving non-receptor tyrosine kinase and phosphatase, which have long been suspected of contributing to the oncogenic potential of Ras, will be discussed in the context of both function and structure.


Page:
S1084952116301689


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