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LATTICE SIMULATION OF NASCENT PEPTIDE FOLDING

Author:
ZHUO, JIAFENG   ZHANG, LINSEN   CHEN, CHANGJUN   HE, YI   XIAO, YI  


Journal:
International Journal of Modern Physics B


Issue Date:
2004


Abstract(summary):

The nascent peptide folding in vivo is different from the denatured peptide refolding in vitro and can be divided into two stages. In the first stage, the peptide is folding as it is being synthesized until the whole peptide chain is synthesized. The final conformation formed in this stage is called as nascent state. In the second stage, the protein folds beginning with the nascent state formed in the first stage into the native state. We use a lattice model to simulate these two stages and investigate the folding time of the nascent peptide comparing with that of the denatured peptide refolding. Our results show that the synthesis process may affect the folding time of the nascent peptide. This may be helpful to understand why the former folds faster than the latter


Page:
2195-2202


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