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Aging: not all DNA damage is equal

Author:
Vermeij, Wilbert P   Hoeijmakers, Jan HJ   Pothof, Joris  


Journal:
Current Opinion in Genetics & Development


Issue Date:
2014


Abstract(summary):

Recent advances have identified accumulation of DNA damage as a major driver of aging. However, there are numerous kinds of DNA lesions each with their own characteristics and cellular outcome, which highly depends on cellular context: proliferation (cell cycle), differentiation, propensity for survival/death, cell condition and systemic hormonal and immunological parameters. In addition, DNA damage is strongly influenced by cellular metabolism, anti-oxidant status and exogenous factors, consistent with the multi-factorial nature of aging. Notably, DNA lesions interfering with replication have very different outcomes compared to transcription. These considerations provide a conceptual framework in which different types of DNA damage and their setting contribute to the aging process in differential manners.


Page:
124-130


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