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Gestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia

Author:
Carr, Darcy B.   Newton, Katherine M.   Utzschneider, Kristina M.   Faulenbach, Mirjam V.   Kahn, Steven E.   Easterling, Thomas R.   Heckbert, Susan R.  


Journal:
Hypertension in Pregnancy


Issue Date:
2011


Abstract(summary):

Objective. We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia. Methods. A retrospective cohort study was performed among 26,105 women. Results. Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83). Conclusion. Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.


Page:
153-163


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