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Percutaneous microwave ablation of larger hepatocellular carcinoma

Author:
Liu, Y.   Zheng, Y.   Li, S.   Li, B.   Zhang, Y.   Yuan, Y.  


Journal:
Clinical Radiology


Issue Date:
2013


Abstract(summary):

| Figures/TablesFigures/Tables | ReferencesReferencesAimTo evaluate the efficacy and safety of percutaneous microwave ablation (MWA) in patients with larger hepatocellular carcinoma (HCC) tumours.Materials and methodsEighty HCC patients with the maximum tumour measuring between 3 and 8?cm were treated using MWA. Of these patients, 57 had initial HCC, while 23 had recurrent HCC. Fifty-two patients had a main tumour measuring 3-5?cm, and 28 had a main tumour measuring 5-8?cm. Local tumour control, complications, long-term survival, and prognostic factors were analysed.ResultsComplete ablation after the initial treatment was achieved in 70 of 80 (87.5%) patients. Sixteen of the 72 (22.2%) successfully treated patients developed local recurrence. Major complications occurred in 7.5% patients. No procedure-related mortality was observed. The 1, 2, 3, and 5 year overall survival rates after the initial ablation were 81.1, 68.2, 56.5, and 34.6%, with a median survival of 56 months. Univariate analysis revealed that small tumour size (p?=?0.003) and pre-ablation α-foetoprotein (AFP) level ?00?ng/ml (p?=?0.042) were favourable prognostic factors of overall survival. Multivariate analysis identified only tumour size as the independent prognosis factor (p?=?0.008).ConclusionPercutaneous MWA is effective and safe for treating larger HCC tumours. The local tumour control and long-term survival are acceptable.


Page:
21-26


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