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Toxicity of echinulin from Aspergillus chevalieri in rabbits

Author:
Ali, Muslim   Mohammed, Nazar   Alnaqeeb, Majed A.   Hassan, Rihab A.H.   Ahmad, Hanan S.A.  


Journal:
Toxicology Letters (Shannon)


Issue Date:
1989


Abstract(summary):

Rabbits were injected intraperitoneally with purified echinulin, a product of Aspergillus chevalieri. After 2h, the rabbits were bled and enzyme analyses were carried out on the supernates of liver homogenates and citrated plasma. Elevated levels of total plasma lactate dehydrogenase, cardiac derived isozyme, glutamic-oxaloacetic and glutamic-pyruvic transaminase activities in animals receiving toxin were observed. These levels were statistically significant compared to the vehicle control. A significant increase in liver lactate dehydrogenase of toxin-treated rabbits was also observed. Light-microscopic examination of lung and liver showed a significant degree of damage. The increase in plasma enzyme levels is indicative of damage to these organs.


Page:
235-241


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