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Clinical and polysomnographic study of RBD in Parkinson’s disease from Egypt

Author:
Mansour, A.   Kamel, T.   Asaad, T.   Metwally, Y.   Aref, H.   Salah, N.  


Journal:
Sleep Medicine


Issue Date:
2013


Abstract(summary):

IntroductionPatients with Parkinson’s disease (PD) are prone to sleep disturbances and disorders with a prevalence of 78-98% (Norlinah et al., 2009). The prevalence of RBD in idiopathic Parkinson’s disease varies from 15% to 58% (Iranzo et al., 2009).The importance of RBD is that it is now considered as an early marker of developing Parkinson’s disease (Arnulf, 2012). Objective: study the clinical and polysomnographic characteristics of PD patients with versus without RBD.Materials and methodsThirty-six PD patients were enrolled from the Involuntary Movement outpatient clinic in Ain Shams University hospital and submitted to clinical assessment by UPDRS- III, Hamilton depression scale, structured sheet for sleep questionnaire, Mayo clinic sleep questionnaire to diagnose RBD, Pittsburgh sleep scale for sleep quality, Epwarth sleepiness scale to assess excessive day time sleepiness. In addition, REM sleep without atonia was assessed, in a one night video-polysomnography (PSG).ResultsThirteen patients (36%) were found to have RBD clinically and confirmed by PSG. RBD patients were of older age (p = 0.086), higher disease severity (p = 0.52), shorter disease duration (p = 0.108), there is was no difference between the RBD+ve group and RBD−ve group as regard to tremors or rigidity as a predominant presentation. PSG analysis showed longer REM latency (p = 0.934), higher periodic leg movement index (PLMI) and respiratory disturbance index (RDI), p = 0.553, 0.198 respectively.ConclusionOur findings support the association between RBD and PD as well as the clinical relevance of sleep disturbances in PD. Association with shorter disease duration may support that it is an early marker of the disease.


Page:
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