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Effects of pregabalin on patients with hypnotic dependent insomnia

Author:
Cho, Y.   Moon, H.   Lee, Y.   Song, M.  


Journal:
Sleep Medicine


Issue Date:
2013


Abstract(summary):

IntroductionLong-term use of hypnotics runs the risk of dependency, and the patient usually experiences difficulties in withdrawal or discontinuing treatment. It has been reported that pregabalin has a positive effect on both sleep and withdrawing from hypnotics. The objective of this study was to investigate the efficacy of pregabalin on sleep in patients with hypnotic dependent insomnia.Materials and methodsThis is a prospective, open-label, single arm, and interventional study. We enrolled patients with hypnotic dependent insomnia who were 18 older. The starting dosage of Pregabalin was 75 mg/day and was increased up to as much as 300 mg/day, depending on the individual patients condition, while tapering off hypnotics. After four weeks of titration, the final dosage amount was maintained for at least another 4 weeks. Sleep and clinical variables were evaluated by using the Pittsburgh Sleep Quality Index (PSQI), Epworth sleepiness scale (ESS), Insomnia Severity Index (ISI), the hospital depression and anxiety scale (HADS), in addition to the polysomnography (PSG) at baseline and after treatment. A paired t-test was used for analyzing the effect of pregabalin using SPSS 18.0 program.ResultsWe enrolled 40 patients whose mean age was 52.33 ± 8.39, 28 were women (70.0%). Twenty-one (52.5%) were successful in withdrawing from hypnotics. The duration of withdrawing from hypnotics was 42.19 ± 16.08 days (range: 27.00-84.00). The mean pregabalin dose was 121.43 ± 69.05 mg/day (range: 75.00-300.00). The results using pregabalin showed a significant improvement with the total score of the PSQI (15.05 ± 2.11, 8.90 ± 3.08, p  0.001), insomnia severity index (20.95 ± 4.32, 9.62 ± 4.41, p  0.001), BDI-2 (7.95 ± 4.20, 5.67 ± 3.69, p = 0.013) and HAS (7.24 ± 4.90, 4.67 ± 3.92, p = 0.002). The main adverse effects of pregabalin were nausea and dizziness.ConclusionOur results showed pregabalin is effective in allowing patients with hypnotic dependent insomnia to withdraw from hypnotics, with a success rate of more than half, and the quality of sleep improved in the group as a whole.AcknowledgementsThis work was supported by a research promoting grant from Pfizer, Korea.


Page:
e98


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