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Methylene Blue for Distributive Shock: A Potential New Use of an Old Antidote

Author:
David H. Jang   Lewis S. Nelson   Robert S. Hoffman  


Journal:
Journal of Medical Toxicology


Issue Date:
2013


Abstract(summary):

Methylene blue is used primarily in the treatment of patients with methemoglobinemia. Most recently, methylene blue has been used as a treatment for refractory distributive shock from a variety of causes such as sepsis and anaphylaxis. Many studies suggest that the nitric oxide–cyclic guanosine monophosphate (NO–cGMP) pathway plays a significant role in the pathophysiology of distributive shock. There are some experimental and clinical experiences with the use of methylene blue as a selective inhibitor of the NO–cGMP pathway. Methylene blue may play a role in the treatment of distributive shock when standard treatment fails.


Page:
242-249


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