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Glucoamylase-like domains in the α- and β-subunits of phosphorylase kinase

Author:
Mark J. Pallen  


Journal:
Protein Science


Issue Date:
2003


Abstract(summary):

Phosphorylase kinase is a four-subunit enzyme involved in the regulation of glycogen breakdown. The traditional textbook view is that only the  subunit has enzymatic activity, whereas the other three subunits have a regulatory role. Evidence from homology searches and sequence alignments, however, shows that the - and -subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase activity. If true, this would have important implications for the understanding, diagnosis, and management of glycogen storage diseases. There is thus a clear need to test this hypothesis through enzymatic assays and structural studies.


Page:
1804-1807


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