Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

Tumor Targeting and Imaging in Live Animals with Functionalized Semiconductor Quantum Rods

Author:
Yong, Ken-Tye   Hu, Rui   Roy, Indrajit   Ding, Hong   Vathy, Lisa A.   Bergey, Earl J.   Mizuma, Masamichi   Maitra, Anirban   Prasad, Paras N.  


Journal:
ACS APPLIED MATERIALS & INTERFACES


Issue Date:
2009


Abstract(summary):

In this contribution, we demonstrate that highly luminescent CdSe/CdS/ZnS quantum rods (QRs) coated with PEGylated phospholipids and conjugated with cyclic RGD peptide can be successfully used for tumor targeting and imaging in live animals. The design of these targeted luminescent probes involves encapsulation of hydrophobic CdSe/CdS/ZnS QRs with PEGylated phospholipids, followed by conjugation of these PEGylated phospholipids to ligands that specifically target the tumor vasculature. In vivo optical imaging studies in nude mice bearing pancreatic cancer xenografts, both subcutaneous and orthotopic, indicate that the QR probes accumulate at tumor sites via the cyclic RGD peptides on the QR surface binding to the alpha(v)beta(3) integrins overexpressed in the tumor vasculature, following systemic injection. In vivo tumor detection studies showed no adverse effects even at a dose roughly 6.5 times higher than has been reported for in vivo imaging studies using quantum dots. Cytotoxicity studies indicated the absence of any toxic effect in the cellular and tissue levels arising from functionalized QRs. These results demonstrate the vast potential of QRS as bright, photostable, and biocompatible luminescent probes for the early diagnosis of cancer.


Page:
710-719


Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads