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Oxygenated cembranoids of the decaryiol type from the Indonesian soft coral Lobophytum sp.

Author:
Ernesto Fattorusso   Adriana Romano   Orazio Taglialatela-Scafati   Carlo Irace   Carmen Maffettone   Giorgio Bavestrello   Carlo Cerrano  


Journal:
Tetrahedron


Issue Date:
2009


Abstract(summary):

Three novel cembrane diterpenoids, decaryiols B-D (5-7). characterized by a bicyclic skeleton of the decaryiol-type, have been isolated from the Indonesian soft coral Lobophytum sp., along with three known cembranoids. The stereostructures of these metabolites have been established through extensive NMR spectroscopic analysis, application of the modified Mosher method, and chemical conversion. cembranoids obtained from Lobophytum sp. (2-7) and six semisynthetic derivatives (9-14) prepared from decaryiol were tested for cell growth inhibitory activity against three different cell lines. O-Methyl decaryiol (10) exhibited a significant and selective activity against glioma cell lines. (C) 2009 Elsevier Ltd. All rights reserved.


Page:
2898-2904


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