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Amplification and overexpression of the epidermal growth factor receptor gene in human renal-cell carcinoma

Author:
Jiro Ishikawa   Sakan Maeda   Kei-Ichi Umezu   Taketoshi Sugiyama   Sadao Kamidono  


Journal:
International Journal of Cancer


Issue Date:
1990


Abstract(summary):

We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (EGFR) gene and found gene amplification in one case of high-stage-high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression of the EGFR gene in 12 of 20 (60%) cases of RCC. The highest expression was observed in the gene-amplified case. No correlation was observed between the level of EGFR mRNA and tumor stage or grade. Northern blot analysis revealed normal 10- and 5.6-kb EGFR mRNA bands in RCC. Our data indicate that gene amplification of the EGFR gene is one of the molecular mechanisms of its overexpression in a subset of RCCs.


Page:
1018-1021


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