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Distribution of Transglutaminase 6 in the Central Nervous System of Adult Mice

Author:
Yu-Tao Liu  Bei-Sha Tang  Wei Lan  Ning-Ning Song  Ying Huang  Lei Zhang  Wen-Juan Guan  Yu-Ting Shi  Lu Shen  Hong Jiang  Ji-Feng Guo  Kun Xia  Yu-Qiang Ding and Jun-Ling Wang  


Journal:
The Anatomical Record


Issue Date:
2013


Abstract(summary):

Our previous study identified a new form of spinocerebellar ataxia (SCA), in which mutations in the gene coding for transglutaminase 6 (TG6) were suggested to be causative. However, the data concerning cellular distribution of TG6 in the brain is still fragmentary. Therefore, we now report a comprehensive immunohistochemical examination of the expression profile of TG6 in adult mouse brain. TG6 was abundantly expressed in the septal region, basal ganglia, hypothalamus and brainstem. Notably, numerous TG6-positive neurons were found in the key brain regions involved in regulating locomotion activity, including the globus pallidus, subthalamic nucleus, substantia nigra, cerebellum, some precerebellar nuclei, and spinal motor neurons. Double immunostaining showed that the vast majority of TG6-positive neurons in the reticular nigra were GABAergic and those in the compact nigra were not dopaminergic. In addition, double staining for TG6 with either anti-NeuN or glial fibrillary acidic protein (GFAP) antibodies demonstrated exclusive NeuN-TG6 co-localization. This study presents a comprehensive overview of TG6 expression in the mouse brain, and provides insight for investigating the role of TG6 in the development of SCA. Anat Rec, 296:1576–1587, 2013.


Page:
1576-1587


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