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Prenatal exposure to nitrosatable drugs, vitamin C, and risk of selected birth defects

Author:
Mayura U. Shinde  Ann M. Vuong  Jean D. Brender  Martha M. Werler  Katherine E. Kelley  John C. Huber Jr  Joseph R. Sharkey  Qi Zheng  Lucina Suarez  Peter H. Langlois  Mark A. Canfield  Paul A. Romitti and Sadia Malik  The National Birth Defects Prevention Study  


Journal:
Birth Defects Research Part A: Clinical and Molecular Teratology


Issue Date:
2013


Abstract(summary):

Nitrosatable drugs, such as secondary or tertiary amines and amides react with nitrite in an acidic environment to form N-nitroso compounds, teratogens in animal models. Vitamin C is a known nitrosation inhibitor.


Page:
515-531


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