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CGRP and NO in the Trigeminal System: Mechanisms and Role in Headache Generation

Author:
Karl Messlinger  Jochen K. Lennerz  Mirjam Eberhardt and Michael J.M. Fischer  


Journal:
Headache: The Journal of Head and Face Pain


Issue Date:
2012


Abstract(summary):

Calcitonin gene-related peptide (CGRP) and metabolic products of nitric oxide (NO) are increased in jugular venous plasma during migraine attacks and other primary headaches. Patients suffering from primary headaches are particularly sensitive to CGRP and NO donors responding with delayed headaches to an infusion of either of these substances. Accordingly, both CGRP and NO are considered as key mediators in migraine, and clinical trials have shown that inhibitors of CGRP receptors and NO synthase are effective in treating migraine. There is an implicit understanding that CGRP and NO systems interact, and here, we review the body of preclinical work on these systems focusing on the trigeminovascular system in migraine.


Page:
1411-1427


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