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The role of CD4+ T cell responses in antitumor immunity

Author:
Pardoll, Drew M   Topalian, Suzanne L  


Journal:
Current Opinion in Immunology


Issue Date:
1998


Abstract(summary):

While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tumor antigens recognized by CD4+ T cells that are restricted by MHC class II are beginning to be defined in both murine and human tumors. These will provide the basis for new generations of antigen-specific tumor vaccines.


Page:
588-594


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