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Author:
Fujita, Tsuyoshi   Shiba, Hideki   Sakata, Masatoshi   Uchida, Yuushi   Ogawa, Tetsuji   Kurihara, Hidemi  


Journal:
Cell Biology International


Issue Date:
2002


Abstract(summary):

Transforming growth factor-β1 (TGF-β1) increases synthesis of secreted protein, acidic and rich in cysteine (SPARC), as well as fibronectin (FN) and type I collagen. However, little is known about the regulatory mechanism of SPARC expression. We examined the effect of FN on SPARC expression by TGF-β1 in cultures of human periodontal ligament cells (HPL cells). TGF-β1 increased the SPARC and SPARC mRNA levels in HPL cells. Extracellular matrix (ECM) produced by HPL cells in the presence of TGF-β1 also increased the SPARC levels. Contents of FN and type I collagen in the ECM were increased by TGF-β1. HPL cells cultured on FN-coated plates secreted more SPARC than those on non-coated plates. However, type I collagen had little effect on SPARC levels. The addition of anti-α5 antibody to the cultures abolished the increase in SPARC mRNA expression by TGF-β1. This study demonstrated that FN may be partly involved in the increase in SPARC expression by TGF-β1 in HPL cells.


Page:
1065-1072


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