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A first comparative map of copy number variations in the sheep genome

Author:
L. Fontanesia   luca.fontanesi@unibo.it   F. Berettia   b   P.L. Martellic   M. Colomboa   S. Dall'Olioa   M. Occidented   B. Portolanob   R. Casadioc   D. Matassinod  V. Russoa  


Journal:
Genomics


Issue Date:
2011


Abstract(summary):

We carried out a cross species cattle–sheep array comparative genome hybridization experiment to identify copy number variations (CNVs) in the sheep genome analysing ewes of Italian dairy or dual-purpose breeds (Bagnolese, Comisana, Laticauda, Massese, Sarda, and Valle del Belice) using a tiling oligonucleotide array with ~ 385,000 probes designed on the bovine genome. We identified 135 CNV regions (CNVRs; 24 reported in more than one animal) covering ~ 10.5 Mb of the virtual sheep genome referred to the bovine genome (0.398%) with a mean and a median equal to 77.6 and 55.9 kb, respectively. A comparative analysis between the identified sheep CNVRs and those reported in cattle and goat genomes indicated that overlaps between sheep and both other species CNVRs are highly significant (P < 0.0001), suggesting that several chromosome regions might contain recurrent interspecies CNVRs. Many sheep CNVRs include genes with important biological functions. Further studies are needed to evaluate their functional relevance.


Page:
158-165


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