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Synthesis of Tc-99m-cationic steroid antimicrobial-107 and in vitro evaluation

Author:
Zahoor, Rizwana  Roohi, Samina  Ahmad, Mushtaq  Iqbal, Zafar  Amir, Nagina  Tariq, Saima  Savage, Paul. B.  


Journal:
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY


Issue Date:
2013


Abstract(summary):

Ceragenins/cationic steroid antimicrobials (CSAs) are a group of cholic acid derivatives with many properties that make them favourable for application as anti-infective agents. CSA-107 is also a member of this group that was labelled with Tc-99m by using SnCl2 center dot 2H(2)O as reducing agent and Na-K tartrate as transchelating agent. Labelling efficiency was optimized by varying the amount of reducing agent, pH, and time of incubation. Labelling efficiency and the stability of Tc-99m-CSA-107 in human serum was determined by paper and thin layer chromatography, which were > 95 and > 90 % respectively. In vitro binding of Tc-99m-CSA-107 was > 95 % determined by using Staphylococcus aureus bacteria.


Page:
841---844


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