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Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits Ca(v)1 2, Ca(v)1 3 and Ca(v)3 1

Author:
Tanaka, Hikaru  Namekata, Iyuki  Ogawa, Toru  Tsuneoka, Yayoi  Komikado, Chisa  Takahara, Akira  Iida-Tanaka, Naoko  Izumi-Nakaseko, Hiroko  Tsuru, Hiromichi  Adachi-Akahane, Satomi  


Journal:
EUROPEAN JOURNAL OF PHARMACOLOGY


Issue Date:
2010


Abstract(summary):

The effect of S(+)-efonidipine on sinus node action potential and calcium channel alpha-subunits was examined The slope of the phase 4 depolarization of isolated rabbit sinus node tissue was significantly reduced by S(+) efonidipine (1 mu M) slightly reduced by nifedipine (1 mu m) but was not affected by R(-) efonidipine S(+) efonidipine (1 mu M) inhibited the expressed Ca(v)1 2 Ca(v)1 3 and Ca(v)3 1 channel currents by 757% 753% and 94 0% nifedipine 84 0% 43 2% and 14 9% and R(-)-efonidipine 30 0% 19 6% and 92 8% respectively Thus the prolongation of the phase 4 depolarization of the rabbit sinus node by S(+) efonidipine may be explained by blockade of the Ca(v)1 3 channel current (C) 2010 Elsevier B V All rights reserved


Page:
263---267


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