Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

Calcitonin gene-related peptide release from intact isolated dorsal root and trigeminal ganglia RID F-7976-2010

Author:
Eberhardt, Mirjam  Hoffmann, Tal  Sauer, Susanne K.  Messlinger, Karl  Reeh, Peter W.  Fischer, Michael J. M.  


Journal:
NEUROPEPTIDES


Issue Date:
2008


Abstract(summary):

Neuropeptides like calcitonin gene-related peptide (CGRP) and substance P are found in significant proportions of primary afferent neurons. Release of these neuropeptides as well as prostaglandin E(2) is an approved index for the activation of these primary afferents. Previous studies have used cultures of enzyme-treated and mechanically dissociated primary afferent neurons, fresh tissue slices or cubes. In the present study we demonstrate CGRP and prostaglandin E2 release from intact isolated dorsal root and trigeminal ganglia. Stimulation with noxious heat, low pH, inflammatory mediators and high potassium concentration increased CGRP release. In conclusion, neuropeptide release from intact isolated ganglia is a reliable method to study the responsiveness of sensory neurons in situ in comparison with neuronal cell cultures. (c) 2008 Elsevier Ltd. All rights reserved.


Page:
311---317


Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads