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Now showing items 1 - 16 of 177

  • SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE

    The objective of the invention is to provide, for semiconductor integrated circuit devices, a structure that can sufficiently ensure an ESD protection capability and a power supply capability for I/O cells without causing increase of the circuit area. In I/O cell columns (10A, 10B), I/O cells (11A, 11B) each for supplying a power supply potential or a ground potential are connected to each other via a power supply sharing wire (31). The I/O cells (11A, 11B) are located at such positions that the I/O cells (11A, 11B) overlie each other in a first direction along which I/O cells (10) are aligned. The power supply sharing wire (31) extends in a second direction orthogonal to the first direction and is connected to first pads (21a, 21b) existing at positions that are closest to the power supply sharing wire (31) in the first direction.
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  • A rare resected case of pulmonary rhabdomyosarcoma

    Nishioka, Yuki   Tane, Shinya   Nishio, Wataru   Tanaka, Hiroki   Ogawa, Hiroyuki   Kitamura, Yoshitaka   Sakuma, Toshiko   Yoshimura, Masahiro  

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  • In memoriam: Shigeyuki Sômiya (1928–2018)

    Yoshimura, Masahiro  

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  • Significant role of Psf3 expression in non-small-cell lung cancer.

    Tane, Shinya   Sakai, Yasuhiro   Hokka, Daisuke   Okuma, Hiromichi   Ogawa, Hiroyuki   Tanaka, Yugo   Uchino, Kazuya   Nishio, Wataru   Yoshimura, Masahiro   Maniwa, Yoshimasa  

    The GINS complex associates with cell division cycle (Cdc) protein 45 and mini-chromosome maintenance (Mcm) proteins 2-7 to form the Cdc45-Mcm-GINS (CMG) complex, which is essential for DNA duplication. One member of the GINS complex is Psf3. We previously found that increased Psf3 expression was strongly associated with poor survival in lung adenocarcinoma. Here, we investigated the role of Psf3 expression in non-small-cell lung cancer (NSCLC). We verified Psf3 expression in human NSCLC tissues (180 patients) and cell lines. Immunohistochemical analysis revealed that the overexpression of Psf3 was significantly associated with vessel invasion (P =3D 0.016), lymphatic invasion (P =3D 0.002), and pleural invasion (P =3D 0.036). The overall survival rate in patients with Psf3 overexpression was significantly lower than that in patients without Psf3 overexpression (P =3D 0.006). Multivariate survival analysis revealed Psf3 expression to be an independent risk factor for an unfavorable outcome (P =3D 0.049). A proximal ligation assay showed interactions between Psf3 and other CMG components (such as Mcm2 and Cdc45) in both NSCLC specimens and cell lines, indicating that Psf3 acted as the CMG complex, which could lead to excessive proliferation. Knockdown of Psf3 inhibited the proliferation of both cell lines by delaying the S phase, which revealed that Psf3 played an important role in cancer proliferation. Thus, Psf3 acted as the CMG complex, promoting excessive proliferation. These results suggest that Psf3 inhibition might be a therapeutic target for NSCLC with Psf3 overexpression. =C2=A9 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
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  • Spin torque diode effect of the magnetic tunnel junction with MnGa free layer

    Tsunegi, Sumito   Mizunuma, Kotaro   Suzuki, Kazuya   Imamura, Hiroshi   Tamaru, Shingo   Yoshimura, Masahiro   Sato, Masashige   Kono, Yasushi   Wado, Hiroyuki   Fukushima, Akio   Kubota, Hitoshi   Mizukami, Shigemi  

    We fabricated a magnetic tunnel junction (MTJ) using an MgO barrier and MnGa electrode, which shows large magnetic anisotropy, and we investigated the spin torque diode effect in the MTJ. The magnetoresistance ratio increased up to approximately 40% by inserting thin FeB/Fe layers at the MnGa/MgO interface. The obtained diode effect was as high as 70 GHz, which is thought to occur due to the coupled precession acoustic mode in the MnGa/Fe-B multi-layer. Numerical simulation suggests that a very high frequency diode signal of more than 150 GHz can be expected in the optical mode precession. Published by AIP Publishing.
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  • Recent topics in catalytic asymmetric hydrogenation of ketones

    Yoshimura, Masahiro   Tanaka, Shinji   Kitamura, Masato  

    Asymmetric hydrogenation of ketones (AHK) was revolutionized in 1987 and again in 1995 when Ru(CH3COO)(2)(binap)/HCl and RuCl2(binap)/diamine, respectively, were developed. Since then, the number of reports on Ru-catalyzed AHK has increased exponentially, and the utility of other precious metals (Os, Rh, Ir and Pd) has also been shown. The utilization of inexpensive base metals (Fe, Co, Ni, and Cu) has been a recent trend. This digest summarizes the key advances in AHK in the past decade by categorizing the chiral ligands into six types: (i) diphosphines, (ii) diphosphines/diamines, (iii) tridentate or tetradentate phosphine amines, (iv) diamines, (v) tetradentate amines, and (vi) tetradentate thioether amines. (C) 2014 Published by Elsevier Ltd.
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  • Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer.

    Tane, Shinya   Nishio, Wataru   Okuma, Hiromichi   Ogawa, Hiroyuki   Hokka, Daisuke   Tane, Kenta   Tanaka, Yugo   Uchino, Kazuya   Yoshimura, Masahiro   Maniwa, Yoshimasa  

    AIM: We examined the advantages of thoracoscopy over thoracotomy in terms of perioperative outcomes and toleration of adjuvant chemotherapy.; METHODS: Between April 2010 and March 2013, 657 patients with non-small-cell lung cancer who underwent lobectomy were classified into thoracoscopy (308 patients) and thoracotomy (349 patients) groups and compared.; RESULTS: The thoracoscopy group had less blood loss compared to the thoracotomy group (p<0.001). When limiting the analysis to pathological stage I patients, the results were similar (p<0.001). In addition, the difference in blood loss between the 2 groups was greater in patients with severe pleural adhesions. The postoperative morbidity of the thoracoscopy group was significantly less than that of the thoracotomy group (13.3% vs. 21.2%, p<0.001), and this result was similar when analyzing the pathological stage I patients (12.6% vs. 20.6%, p=3D0.001). A higher percentage of the thoracoscopy group received both the full planned course and dose of adjuvant chemotherapy compared to the thoracotomy group (84.2% vs. 65.8%, p=3D0.032).; CONCLUSIONS: These results indicate that totally thoracoscopic lobectomy is the more beneficial surgical approach with regard to the incidence of postoperative complications and toleration of adjuvant chemotherapy. =C2=A9 The Author(s) 2015.
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  • Total thoracoscopic posterior basal segmentectomy for primary lung cancer.

    Nishio, Wataru   Tane, Kenta   Uchino, Kazuya   Yoshimura, Masahiro  

    This report introduces a hilar side approach for posterior basal segmentectomies by the process of specific vision thoracoscopic surgery, which has been used extensively for peripheral small lung cancer by the author. Although it requires a deeper understanding of hilar anatomy and fine control, it is safer and less invasive to the thoracic wall and results in less postoperative pain than the thoracotomy counterpart and as a hilar side approach allows for less deformation. The necessary order of processes involves specific vision, inflation-deflation and blunt dissection from the hilum. =C2=A9 The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
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  • Psf3 is a prognostic biomarker in lung adenocarcinoma

    Hokka, Daisuke   Maniwa, Yoshimasa   Tane, Shinya   Nishio, Wataru   Yoshimura, Masahiro   Okita, Yutaka   Ohbayashi, Chiho   Sakai, Yasuhiro   Chen, Xue   Hayashi, Yoshitake  

    Psf3 is a member of the evolutionarily conserved heterotetrameric complex GINS (Go-lchi-Ni-San), which consists of SId5, Psf1, Psf2, and Psf3. Previous studies have suggested that some GINS complex members are upregulated in cancer, but the status of Ps13 expression in lung adenocarcinoma has not been investigated. The objective of the current study was to determine whether Psf3 plays a role in lung adenocarcinoma by investigating clinical samples. We investigated the status of Psf3 expression in cancer cells of 125 consecutive resected lung adenocarcinomas by immunohistochemistry. Increased Psf3 expression was observed in 27(21.6%) of the 125 cases. Further, univariate analysis and log-rank test indicated a significant association between Psf3 expression and lower overall survival rate (P=0.0001 and P<0.0001, respectively). Multivariate analysis also indicated a statistically significant association between increased Psf3 expression and lower overall survival rate (hazard ratio, 5.2; P=0.0027). In a subgroup analysis of only stage I patients, increased Psf3 expression was also significantly associated with a lower overall survival rate (P=0.0008, log-rank test). Moreover, the Ki67 index level was higher in the Psf3-positive group than in the Psf3-low positive group (P<0.0001, Mann-Whitney U-test). Our results indicated that Psf3 can serve as a prognostic biomarker in lung adenocarcinoma. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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  • Expression of nectin 3: Novel prognostic marker of lung adenocarcinoma

    Maniwa, Yoshimasa   Nishio, Wataru   Okita, Yutaka   Yoshimura, Masahiro  

    Background: We investigated the prognostic significance of the immunoglobulin-like cell adhesion molecule nectin-3, a regulator of the formation of adherens junctions, in human lung adenocarcinoma. Methods: Tumor-tissue samples of 127 patients with surgically resected lung adenocarcinoma were used for analysis of the proteins expression by immunohistochemistry. Results: Of the 127 patients, 25% showed membranous expression of nectin-3, and others showed negative or cytoplasmic expression. Membranous expression of nectin-3 was found to be a prognostic factor for decreased overall survival on univariate analysis (P = 0.001). Multivariate Cox proportional hazards model analyses also revealed that membranous expression of nectin-3 turned out to be an independent prognostic factor (P = 0.048). Moreover, in tumors expressing membranous nectin-3, some tumors did not co-localize with E-cadherin, and the patients of such tumors showed poorer prognosis than other patients for overall survival on univariate analysis (P < 0.03). Conversely, membranous expression of nectin-3 with E-cadherin co-localization was found to associate with good prognosis of patients. Conclusion: Membranous expression of nectin-3 was an independent prognostic factor of lung adenocarcinoma, and it might play an important role in progression of the tumor.
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  • Two-Dimensional Titanium Carbide (MXene) as Surface-Enhanced Raman Scattering Substrate

    Sarycheva, Asia   Makaryan, Taron   Maleski, Kathleen   Satheeshkumar, Elumalai   Melikyan, Armen   Minassian, Hayk   Yoshimura, Masahiro   Gogotsi, Yury  

    Noble metal (gold or silver) nanoparticles or patterned films are typically used as substrates for surface-enhanced Raman spectroscopy (SERS). Two-dimensional (2D) carbides and nitrides (MXenes) exhibit unique electronic and optical properties, including metallic conductivity and plasmon resonance in the visible or near infrared range, making them promising candidates for a wide variety of applications. Herein, we show that 2D titanium carbide, Ti3C2Tx, enhances Raman signal from organic dyes on a substrate and in solution. As a proof of concept, MXene SERS substrates were manufactured by spray-coating and used to detect several common dyes, with calculated enhancement factors reaching, similar to 10(6). Titanium carbide MXene demonstrates SERS effect in aqueous colloidal solutions, suggesting the potential for or environmental applications, where biomedical MXene can selectively enhance positively charged molecules.
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  • ChemInform Abstract: Recent Topics in Catalytic Asymmetric Hydrogenation of Ketones

    Yoshimura, Masahiro   Tanaka, Shinji   Kitamura, Masato  

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  • Low-temperature Ammonothermal Synthesis of LaTaON(2)

    Watanabe, Tomoaki   Tajima, Keisuke   Li, JinWang   Matsushita, Nobuhiro   Yoshimura, Masahiro  

    Pure perovskite-type LaTaON(2) crystal powders with high crystallinity were synthesized in supercritical ammonia using sodium amide as a flux. The synthesis temperature for this new method is 873 K., approximately 300 K lower than that for previous methods. The obtained powders have a pseudocubic lattice with a lattice constant of alpha = 0.4049 nm, which is in good agreement with the reported value.
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  • Importance of nucleation in transformation of octacalcium phosphate to hydroxyapatite.

    Ito, Natsuko   Kamitakahara, Masanobu   Yoshimura, Masahiro   Ioku, Koji  

    Octacalcium phosphate (OCP) is regarded as an in vivo precursor of hydroxyapatite (HA). It is important to understand the mechanism of transformation of OCP to HA in order to reveal the mechanism of mineralization and help in the development of artificial bone-repairing materials. Herein, we have examined the behavior of OCP in a simulated body fluid (SBF) and pure water. The OCP particles immersed in the SBF at 37 =C2=B0C did not transform to HA even after 720 h of immersion, though the particles showed crystal growth. In distilled water at 60 =C2=B0C, the OCP particles transformed to HA but the unreactive period was observed. Although the immersed solution became supersaturated with HA within 12h of immersion, the OCP was not transformed in the first 36 h of immersion. These results indicate that the nucleation of HA is the rate-determining step in the transformation of OCP to HA. Copyright =C2=A9 2014 Elsevier B.V. All rights reserved.
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  • Numerical simulation of pore evolution during liquid-phase sintering

    Nikolic, Zoran S.   Yoshimura, Masahiro  

    Pore evolution by pore filling and pore growth during liquid-phase sintering was investigated numerically. Pore growth by pore coalescence was treated as the nearly instantaneous formation of one large pore upon contact of two smaller pores. In that sense, three different types of pore replacement, irregular (pore skeleton), circular and ellipsoidal, were defined and applied for the study of diffusional effects on the microstructural development of the porous W-Ni system. (C) 2010 Elsevier Ltd. All rights reserved.
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  • Desymmetric hydrogenation of a meso-cyclic acid anhydride toward biotin synthesis

    Yoshimura, Masahiro   Tsuda, Kazuomi   Nakatsuka, Hiroshi   Yamamura, Tomoya   Kitamura, Masato  

    Catalytic reactivity in the hydrogenation of a cyclic anhydride to a biotin synthetic intermediate has been investigated on the basis of Lyons' original method using Wilkinson Ru complex, revealing the high performance of DPPF and XANTPHOS diphosphines possessing wide bite angles. The results have shown a new trail for design of the corresponding asymmetric catalysts, and the potential utility of (S,S)-Et-FerroTANE and (S,S)-(R,R)-Ph-TRAP has been demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.
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