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Now showing items 17 - 32 of 44

  • Hydrogeological Classification and Water Inrush Accidents in China’s Coal Mines

    Wenjie Sun   Wanfang Zhou   Jian Jiao  

    In 2012, China’s State Administration of Coal Mine Safety conducted a reconnaissance and statistical analysis to better understand and characterize water inrush accidents in China’s coal mines. Data collected from 12,985 mines from 26 provinces and municipalities were used to study each mine’s hydrogeological classification, water content coefficient, and the level of effort being spent in preventing and controlling these accidents. Analysis of the water inrush accidents in these mines suggests that their likelihood reflects a mine’s hydrogeological characteristics, and that they can be controlled by professionals who are specifically trained for mine water prevention and emergency responses. In terms of hydrogeological complexity, there were 78 extremely complex coal mines, 827 complex mines, 4141 moderately complex mines, and 6458 relatively simple mines. Advances in mine water control and management methods and techniques and implementation of safety standards and regulations have significantly reduced the number of people killed per ton of coal produced, but analysis of the 2013 water hazard accidents indicates that continued effort is needed to better understand hydrogeological classification and implement safe procedures in water prospecting and dewatering.
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  • The impact of temperature and humidity measures on influenza A (H7N9) outbreaks—evidence from China

    Yi Zhang   Cindy Feng   Chunna Ma   Peng Yang   Song Tang   Abby Lau   Wenjie Sun   Quanyi Wang  

    Highlights • Our models flexibly modeled the non-linear effects of meteorological factors and age. • Both minimum and maximum temperature contributed to human infection with the influenza A H7N9 virus. • Humidity and daily temperature differences were not significantly associated with the incidence of H7N9. • On the date of disease onset and during the 2 weeks prior to disease onset, the model including minimum or maximum temperature on day 13 prior to disease onset as the temperature covariate had the best predictive ability. Summary Objectives To examine the non-linear effects of meteorological factors on the incidence of influenza A H7N9 and to determine what meteorological measure, and on which day preceding symptom onset, has the most significant effect on H7N9 infection. Methods We applied a zero truncated Poisson regression model incorporating smoothed spline functions to assess the non-linear effect of temperature (maximum, minimum, and daily difference) and relative humidity on H7N9 human case numbers occurring in China from February 19, 2013 to February 18, 2014, adjusting for the effects of age and gender. Results Both daily minimum and daily maximum temperature contributed significantly to human infection with the influenza A H7N9 virus. Models incorporating the non-linear effect of minimum or maximum temperature on day 13 prior to disease onset were found to have the best predictive ability. For minimum temperature, high risk was found to range from approximately 5 to 9 °C and moderate risk from −10 to 0 °C; temperatures of >9 °C represented a low risk. For maximum temperature, high risk was found to range from approximately 13 to 18 °C and moderate risk from 0 to 4 °C; temperatures of >18 °C represented a low risk. Relative humidity was not significantly associated with the incidence of infection. The incidence of H7N9 was higher for males compared to females ( p < 0.01) and it peaked at around 60–70 years of age. Conclusions We provide direct evidence to support the role of climate conditions in the spread of H7N9 and thereby address a critical question fundamental to our understanding of the epidemiology and evolution of H7N9. These findings could be used to inform targeted surveillance and control efforts aimed at reducing the future spread of H7N9.
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  • Long non-coding RNA LINC01133 inhibits epithelial–mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6

    Jianlu Kong   Wenjie Sun   Chen Li   Ledong Wan   Shuo Wang   Yihua Wu   Enping Xu   Honghe Zhang   Maode Lai  

    Highlights • LINC01133 is a repressor of epithelial–mesenchymal transition (EMT) and metastasis in colorectal cancer . • LINC01133 directly binds to splicing factor SRSF6 and blocks its function of inducing the EMT in colorectal cancer. • LINC01133 is downregulated in colorectal cancer, and its overexpression is correlated with good survival. Abstract Long non-coding RNAs (lncRNAs) play crucial roles in many biological and pathological processes, including tumor metastasis. Here we reported a novel lncRNA, LINC01133 that was downregulated by TGF-β, which could inhibit epithelial–mesenchymal transition (EMT) and metastasis in colorectal cancer (CRC) cells. An alternative splicing factor SRSF6 was identified to directly interact with LINC01133, and SRSF6 promoted EMT and metastasis in CRC cells independent of LINC01133 And we confirmed that the EMT process was regulated by LINC01133 in CRC cells dependent on the presence of SRSF6. The observation for LINC01133 to inhibit metastasis was also verified in vivo . Moreover clinical data showed that the LINC01133 expression was positively correlated with E-cadherin, and negatively correlated with Vimentin, and there was a robust association of low LIINC01133 expression in tumors with poor survival in CRC samples. These data suggest that LINC01133 inhibits the EMT and metastasis by directly binding to SRSF6 as a target mimic, and may serve as a prognostic biomarker and an effective target for anti-metastasis therapies for CRC.
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  • Effect of BaO Addition on Densification and Mechanical Properties of Al2O3-MgO-CaO Refractories

    Lei Liu   Min Chen   Lei Xu   Xueliang Yin   Wenjie Sun   Hugo F. Lopez  

    Considering the requirement for a reduction of refractory consumption; the present work investigated the fabrication of Al2O3-MgO-CaO-based refractory with BaO addition by means of solid-state reaction sintering. The effect of BaO addition on densification and the properties of the refractory were also discussed. Results indicated that the formation of calcium hexaluminate (CaO ̈ 6Al2O3; or CA6) grains with a high aspect ratio in the alumina-rich zone depressed the densification of the sample without BaO addition; resulting in a higher apparent porosity of 21.2%. When 6 wt. % BaO was added; a new phase of Ba2Mg6Al28O50 (BAM) with a lower aspect ratio was formed and the densification of the sample with an apparent porosity of 5.52% was promoted. In addition; mechanical performance was significantly improved due to an increase in compactness and modification of the microstructure. The cold compressive strength increased from 348 MPa to 569 MPa and the flexural strength increased from 178 MPa to 243 MPa by addition of 6 wt. % BaO. Meanwhile; the breadth of the widest crack after the thermal shock test decreased from 7 μm to 1 μm in the refractory.
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  • A Model of Web Service Discovery Based on BalanceChord

    Li Chen   Zilin Song   Shiming Zheng   Wenjie Sun   Zhanfeng Wang  

    The research of Web service discovery can be distinguished into two layers: service discovery model and service discovery algorithm. In this paper a kind of services discovery model named WSDBC (Web Service Discovery based on BalanceChord) is proposed in order to extend the Web services discovery scope and improve discovery efficiency. In order to achieve load balancing between different nodes in WSDBC model; node join-in algorithm and self-balancing algorithm are proposed. When a new node joins in the BalanceChord; it must get the network load information and set its identifier in order to share the load of overloaded node. By the self-balancing algorithm a node would periodically compare its load with its neighbors and share its load clockwise. A simulative system ChordSim is designed and implemented. Experimental results show this model and algorithms have a good performance.
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  • Sustainable cooling

    Wenjie Sun  

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  • H7N9 not only endanger human health but also hit stock marketing

    Yan Jiang   Yi Zhang   Chunna Ma   Quanyi Wang   Chao Xu   Connor Donovan   Gholam Ali   Tan Xu   Wenjie Sun  

    OBJECTIVE This study aims to discuss the correlation between daily reported H7N9 cases and stock price indices in China. METHODS Information on daily reported H7N9 cases and stock market sectors indices between February 19; 2013 and March 31; 2014 were collected. A distributed lag non-linear model was used to describe the variation trend for the stock indices. RESULTS The daily reported number of H7N9 cases was associated with the closing price of the Avian Influenza Sector Index (P < 0.05) and the opening price of the Shanghai Composite Index (P = 0.029). The Avian Influenza Sector Index decreased with increasing of daily reported case number when daily reported cases ≤ 4. Case number was associated with the opening/closing price of the Chinese Traditional Medicine Sector Index; the Biological Product Sector Index; and the Biomedicine Sector Index (P < 0.05). CONCLUSION New or reemerging infectious diseases epidemic cause economic loss which is reflected in movements in stock prices.
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  • HTNV infection of CD8~+T cells is associated with disease progression in HFRS patients

    Rongrong Liu;Ruixue Ma;Ziyu Liu;Shiyuan Hou;Yunhua Lv;Wenjie Sun;Xingan Wu;  

    Hantaan viruses(HTNVs) are zoonotic pathogens transmitted mainly by rodents and capable of infecting humans.Increasing knowledge of the human response to HTNV infection can guide the development of new preventative vaccines and therapeutic strategies.Here,we presentfor the first time that HTNV can infect CD8~+T cells in patients diagnosed with hemorrhagic fever with renal syndrome(HFRS).Electron microscopy-mediated tracking of the life cycle and ultrastructure of HTNV-infected CD8~+T cells showed an association between notable increases in multivesicular bodies and virus production.Moreover,single-cell RNA sequencing analysis of primary human CD8+T cells revealed that HTNV infection in vitro drives naive CD8~+T cells to diffe rentiate into four distinct clusters characterized by unique transcriptome profiles.Significantly,based on a clinical cohort of 280 subjects,we found that circulating HTNV-infected CD8~+T cell levels were proportional to disease severity.These results demonstrate viral CD8~+T cells may be used as an adjunct marker for monitory HFRS disease progression and suggest specific areas where new treatment strategies for HTNV may be explored.
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  • Sprouty4 regulated vascular permeability by regulating the tyrosine phosphorylation and degradation of VE-cadherin

    Jiangbo Ren;Nannan Zhang;Wenjie Sun;Yuan Luo;Yuke Gao;Yan Gong;Department of Biological Repositories,Zhongnan Hospital of Wuhan University;Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University;  

    Regulation of endothelial cell adherent junctions is important to pathophysiological processes, in which vascular integrity is disrupted such as during tumor angiogenesis and chronic inflammatory conditions. The effects of Sprouty4(Spry4) on endothelial barrier function was investigated using vascular endothelial cell growth factor(VEGF)-induced vascular permeability model. In the present study we showed that overexpression of Spry4 inhibited vascular permeability in primary human endothelial cells in vitro and in Spry4-expressing transgenic mice in vivo. Conversely, knockdown of Spry4 in vitro and conditional endothelial cell-specific knockout of Spry4 in endothelial cells in vivo enhanced VEGF-induced vascular permeability. In addition, overexpression of Spry4 inhibited VEGF-induced vascular endothelial cadherin(VE-cadherin) tyrosine phosphorylation, in part by inhibiting c-Src activation, and resistance to VEGF-induced vascular permeability. Inhibition of VEGF-induced VE-cadherin tyrosine phosphorylation and decreased vascular permeability by Spry4 overexpression could be rescued by expression of constitutively active c-Src. Conversely, knockdown of Spry4 in endothelial cells increased tyrosine phosphorylation of VE-cadherin and vascular permeability, which was repressed by dominant negative Src(DNSrc). Consistent with these results, DNSrc repressed the increase in vascular permeability that resulted due to knockdown of Spry4. Taken together, these results suggested that Spry4 regulated vascular permeability via regulating the activation of c-Src by VEGF signaling and consequently the tyrosine phosphorylation of VE-cadherin.
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  • Risk stratification of decompensated cirrhosis patients by Chronic Liver Failure Consortium scores: Classification and regression tree analysis

    Yu Shi   Zheyue Shu   Wenjie Sun   Qiao Yang   Ye Yu   Gang Yang   Wei Wu   Si Chen   Wei Huang   Tingting Wang   Huadong Yan  

    Aim Decompensated cirrhosis patients have greatly variable prognosis. The aim of the study was to carry out a risk stratification for those patients by Chronic Liver Failure (CLIF) Consortium scores. Methods The performance of CLIF Consortium acute‐on‐chronic liver failure scores (CLIF‐C ACLFs) and CLIF Consortium Acute Decompensation scores (CLIF‐C ADs) were validated in 209 patients with ACLF and 1245 patients without ACLF at admission from the Ningbo Cohort. A classification and regression tree (CRT) analysis by CLIF‐C ACLFs/CLIF‐C ADs was carried out to stratify death risk among patients. Results The CLIF‐C ACLFs and CLIF‐C ADs showed higher predictive accuracy than Model for End‐stage Liver Disease (MELD) scores, MELD plus serum sodium (MELD‐Na) scores, and Child–Turcotte–Pugh classification (CP) at main time points (28, 90, 180, and 365 days), determined by area under the receiver–operating characteristic curve and concordance index in ACLF and no‐ACLF patients at admission. The CRT analysis categorized ACLF patients into two groups (advanced and early ACLF), and no‐ACLF patients into three groups (high‐, medium‐, and low‐risk AD) according to risk of death. However, early ACLF and high‐risk AD patients had comparable mortality at the main time points. The CRT model had a higher area under the receiver–operating characteristic curve than MELDs, MELD‐Nas, and CPs in predicting prognosis in all patients. Conclusions The CLIF‐C ACLF and CLIF‐C AD are better prognostic scores than MELD, MELD‐Na, and CP in predicting mortality of ACLF and no‐ACLF patients. A combined use of CLIF– Sequential Organ Failure Assessment, CLIF‐C ACLFs, and CLIF‐C ADs could identify cirrhosis patients at high death risk and assist clinical decisions for management.
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  • Avoiding Coal-water Conflicts During the Development of China's Large Coal-producing Regions

    Wenjie Sun   Qiang Wu   Donglin Dong   Jian Jiao  

    Coal and water resources are important and fundamental to the sustainable development of China's national economy and society. However, coal-water conflicts are beginning to restrict coal production. In order to study this serious problem, the threat of mine water disasters, the supply-demand imbalance of water resources in coal mining areas, and the nature of polluted mine water were considered. Our results show that these problems are best resolved by viewing coal and water as coupled resources, using an optimized five fold combination of mine water control, treatment, utilization, groundwater recharge, and environment-friendly treatment. Water that is pumped to the surface to make a mine safer to operate can be used without being treated if it is kept separate from contaminated mine water and can be a resource, as can mine water that has been properly treated.
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  • Nutritional Intervention and Breakfast Behavior of Kindergartens

    Yongqing Gao   Chunsheng Cai   Jian Li   Wenjie Sun  

    BACKGROUND To examine the effect of nutritional education on children's breakfast patterns. METHODS A kindergarten based nutrition intervention was started in September 2001 among 8 kindergartens in Hefei with a total of 2;012 children aged 4-6 years and their parent pairs. RESULTS Monthly nutrition education sessions were held over two semesters in kindergartens part of the intervention arm. The approach in education and the content of other activities were uniform across all the kindergartens. A validated questionnaire was used to record breakfast behavior over 7 days including at least one weekend. The parents recorded the children's breakfast pattern (frequency; time; and food selection) at baseline; middle; and end of the study. After intervention; there were significant differences at the final stage; but none at the baseline before intervention. There were changes not only in breakfast frequency; but also in the breakfast selection. CONCLUSION The breakfast pattern of Chinese children can be modified through nutrition education after a long term intervention.
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  • Sleep duration associated with body mass index among Chinese adults

    Wenjie Sun   Yuee Huang   Zengzhen Wang   Yaqin Yu   Abby Lau   Gholam Ali   Ping Huang   Yunlong Geng   Tan Xu   Guangliang Shan  

    Highlights • Short sleep is common in China. • Sex modified sleep obesity. • Short sleep increased obesity in men. Abstract Objective The objective of this study was to investigate the relationship between sleep duration and obesity among Chinese adults. Methods A community-based cross-sectional study was conducted among Chinese adults in 2008. In total, 3225 participants were selected by a multistage cluster sampling method. Self-reported sleep duration was measured by a standardized questionnaire. Logistic regression models were used to estimate the odds ratios (ORs) (95% confidence intervals, CIs) of obesity with sleep duration, separated by gender, and adjusted for age, education, occupation, marriage, smoking, drinking, body pain, and health status. Results The mean sleep duration was 7.8 h. Among the 2962 participants, 7.2% had short sleep duration (≤6 h/day). There were 171 obese participants (5.7%) in this population. After adjustment for age, short sleep duration (<6 h) was significantly associated with obesity among men (OR: 2.15; 95% CI: 1.193.90), but not among women; additional adjustment for potential confounders did not attenuate the association among men. Increasing sleep duration (a continuous variable) was significantly and negatively associated with obesity in women after adjustment for education level, occupation, marital status, smoking, drinking, body pain, and health status. The adjusted OR per-hour increase in sleep duration was 0.74 (0.56–0.97) for obesity, suggesting that for a 1-h increase in sleep duration among women, obesity risk decreased by 26%. Conclusion Short sleep duration was associated with increasing obesity in Chinese men, and sleep duration was associated with obesity in Chinese women, although the underlying mechanism is unclear. This possible gender difference warrants further studies.
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  • Association of Information Sources and Knowledge on HIV/AIDS in Rural China.

    Yufeng Wen   Huadong Wang   Baifeng Chen   Yujuan Chen   Tiejun Zhang   Tan Xu   Wenjie Sun  

    OBJECTIVE To investigate the association between the number of available information sources on HIV/AIDS and HIV/AIDS-related knowledge in a rural population in China. DESIGN We performed a cross-sectional survey on the number and types of sources of HIV/AIDS information available to rural residents of China and assessed HIV/AIDS-related knowledge in this population. We collected information from 5,355 Chinese rural residents and then correlated the results of the scores on knowledge to the numbers of information sources, and adjusted for age, sex, education and occupation. RESULTS The sources of HIV/AIDs information reported by subjects included television, radio, newspapers, periodicals, discussions with neighbors and friends. There were significant differences in sources of information based on gender, occupation, educational level and age. The average number of information sources was 3.01 ± 1.74. The average score on the AIDS related knowledge questionnaire was 8.21 ± 4.23. Subjects who reported 6 sources of HIV/AIDS information had an average score of 11.67 ± 3.0 on the HIV/AIDS knowledge questionnaire. Subjects who reported between 3-7 sources of HIV/AIDS information had significantly higher scores than those who had 1,2 or 8 sources of information. CONCLUSIONS There is an association between HIV/AIDS knowledge and the number of available information sources. By increasing the sources, one could not always make more people curious or interested in HIV/AIDS knowledge.
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  • Dendrimer-based magnetic iron oxide nanoparticles: their synthesis and biomedical applications

    Wenjie Sun   Serge Mignani   Mingwu Shen   Xiangyang Shi  

    Highlights • Dendrimers with unique properties can used to form multifunctional MIO NPs. • Various synthetic strategies used to form dendrimer-based MIO NPs are summarized. • Dendrimer-based MIO NPs can be used for different biomedical applications. • Outlooks of dendrimer-based MIO NPs for biomedical applications are discussed. Magnetic iron oxide nanoparticles (MIO NPs) bearing different appropriate surface modifications can be prepared using diverse physical and chemical methods. As an ideal macromolecule, dendrimers have attracted considerable attention because of their unique properties, including their three 3D architecture, monodispersity, highly branched macromolecular characteristics, and tunable terminal functionalities. These properties make dendrimers a powerful nanoplatform for the creation of functional organic and/or inorganic hybrid NPs, in particular dendrimer-based MIO NPs. Here, we report on recent advances in the preparation of dendrimer-based MIO NPs for different biomedical applications, such as magnetic resonance (MR) imaging, drug and gene delivery, and protein immobilization. Teaser The development and synthesis of dendrimer-based magnetic iron oxide nanoparticles formed through different synthetic strategies for various biomedical applications are discussed.
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  • Review of recent advances of polymer based dielectrics for high-energy storage in electronic power devices from the perspective of target applications

    Wenjie Sun   Jiale Mao   Shuang Wang   Lei Zhang[1,2]   Yonghong Cheng  

    Polymer-based dielectric capacitors are widely-used energy storage devices.However,although the functions of dielectrics in applications like high-voltage direct current transmission projects,distributed energy systems,high-power pulse systems and new energy electric vehicles are similar,their requirements can be quite different.Low electric loss is a critical prerequisite for capacitors for electric grids,while high-temperature stability is an essential pre-requirement for those in electric vehicles.This paper reviews recent advances in this area,and categorizes dielectrics in terms of their foremost properties related to their target applications.Requirements for polymer-based dielectrics in various power electronic equipment are emphasized,including high energy storage density,low dissipation,high working temperature and fast-response time.This paper considers innovations including chemical structure modification,composite fabrication and structure re-design,and the enhancements to material performances achieved.The advantages and limitations of these methods are also discussed.
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