The aim of this study was to investigate the effects and possible mechanisms of ghrelin receptor (GHS-R) deficiency on gastric motility in GHS-R deficient (Ghsr(-/-)) mice. Ghsr(-/-) and control (Ghsr(+/+)) mice were genotyped by PCR. The percentage of gastric emptying (GE%) was calculated following the intraperitoneal administration of ghrelin. In vitro, the contractile response of smooth muscle strips to ghrelin and electrical field stimulation (EFS) and the intraluminal pressure change of isolated stomach to carbachol were observed in an organ bath. The staining of nerve cells in the gastric muscle layer was performed by immunofluorescence. Delayed gastric emptying was observed in the Ghsr(-/-) mice; ghrelin enhanced the GE% in the Ghsr(+/+) mice but had no effect on the GE% in the Ghsr(-/-) mice. In vitro, the response of the strips to ghrelin and EFS and the intraluminal pressure change to cabarchol was reduced in the Ghsr(-/-) mice. GHS-Rs were predominantly expressed on nerve cells in gastric muscle layers. The number of nerve cells was observed to be decreased in the Ghsr(-/-) mice. The delayed gastric emptying may relate to the loss of GHS-Rs and the reduction in the number of nerve cells in the gastric muscle layers of the GHS-R-deficient mice.
The multiple instance regression problem has become a hot research topic recently. There are several approaches to the multiple instance regression problem, such as Salience, Citation KNN, and MI-ClusterRegress. All of these solutions work in batch mode during the training step. However, in practice, examples usually arrive in sequence. Therefore, the training step cannot be accomplished once. In this paper, an online multiple instance regression method ldquoOnlineMIR" is proposed. OnlineMIR can not only predict the label of a new bag, but also update the current regression model with the latest arrived bag. The experimental results show that OnlineMIR achieves good performances on both synthetic and real data sets.
A new mononuclear dysprosium complex formulated as [Dy(dppz) (tfnb)(3)]center dot 0.375H(2)O (dppz=dipyrido [3,2-a:2',3'-c]phenazine; tfnb= 4,4,4-trifluoro-1 -(2-naphthyl)-1,3- butanedione) was synthesized, structurally and magnetically characterized. X-ray diffraction study reveals that the central Dy-III ion in the complex adopts an approximately square-antiprismatic (SAP) geometry. The complex shows frequency-dependent ac magnetic susceptibilities, indicating single-ion magnet behavior. (C) 2012 Elsevier B.V. All rights reserved.
In this paper, we derive several sufficient conditions of the linear combinations of harmonic univalent mappings to be univalent and convex in the direction of the real axis. Furthermore, some illustrative examples and imagine domains of the linear combinations satisfying the desired conditions are enumerated. (C) 2012 Elsevier Inc. All rights reserved.
A hexanuclear metallamacrocycle complex [Ni(iPr3tacn)(dca)(PF6)]6 (1) was obtained by using the tridentate ligand 1, 4, 7-triisopropyl-1, 4, 7-triazacyclononane (iPr3tacn) and the flexible ligand dicyanamide (dca). The complex was characterized by X-ray crystallography and magnetic measurements. Complex 1 contains hexacyclic rings adopting chair conformation, which can be described as metallamacrocycle. Variable-temperature magnetic measurements reveal antiferromagnetic interactions across the single end-to-end dca bridges in compound 1.
In this article, I calculate the contributions of nuclear-matter-induced condensates up to dimension 5, take into account the next-to-leading order contributions of the nuclear-matter-induced quark condensate, study the properties of the scalar, pseudoscalar, vector, and axial-vector heavy mesons in nuclear matter with the QCD sum rules in a systematic way, and obtain the shifts of the masses and decay constants. Furthermore, I study the heavy-meson-nucleon scattering lengths as a byproduct, and conclude qualitatively about the possible existence of heavy-meson-nucleon bound states.
The microstructure of bainite ferrite in NANOBAIN steel transformed at different temperatures was investigated by scanning electron microscopy, transmission electron microscopy, electron back-scattered diffraction, and vickers hardness tester in detail. It is found that the average width of bainitic ferrite (BF) plates can be refined to be thinner with the reduction of temperature (473-573 K), and the bainitic ferrite plates can reach up to 20-74 nm at 473 K. Crystallographic analysis reveals that the bainitic ferrite laths are close to the Nishiyama-Wasserman orientation relationship with their parent austenite. Temperature shows a significant effect on the variant selection, and a decrease in temperature generally weakens the variant selection. Thermodynamic analyses indicates that the Lacher, Fowler and Guggenheim (LFG) model is more suitable than the Kaufman, Radcliffe and Cohen (KRC) model dealing with NANOBAIN steel at a low temperature range. The free energy change Delta G(gamma -> BF) is about -1500 J.mol(-1) at 473 K, which indicates that nucleation in NANOBAIN steel is the shear mechanism. Finally, the formation of carbon poor regions is thermodynamically possible, and the existence of carbon poor regions can greatly increase the possibility of the shear mechanism.
To introduce boron (B) into the Sn-1.0Ag-0.5Cu (SAC105) solder, based on the thermodynamic calculations, iron (Fe) is a competent carrier component for bonding B and Sn. The Sn-Fe-B master alloys were prepared by mechanical alloying initially; then, the SAC105-0.05(Fe-B) and SAC105-0.1(Fe-B) solder alloys were prepared using 72-h-milling Sn-Fe-B master alloys. The preparation process and the properties of solders were studied in this work. For the Sn-Fe-B master alloys, the results show that with the increase in the ball-milling time, the powder changes illustrate a cold welding-crushing-cold welding cyclic process. Moreover, the supersaturated solid solubility of (Fe-B) increases gradually in the alloys' matrix and the lattice distortion increases to 0.167% after 72-h milling. Meanwhile, the alloying degree is increasingly apparent, and after 72-h milling, the content of B in the Sn matrix reaches 2.38 wt%. For the solder alloys, with the (Fe-B) content increasing, the melting point decreases and a significant grain refinement occurs in the matrix. Compared to the benchmark SAC105, the hardness of SAC105-0.05(Fe-B) and SAC105-0.1(Fe-B) solder alloys prepared by this method is improved by 20.65% and 34.79%, respectively. The present research provides a novel approach for introducing the immiscible component into the lead-free solder alloys.
Well-defined and uniform pore-structure (WDUPS) Al2O3 catalyst supports were prepared by coating specially treated SiO2 opals with Al2O3. The pore-size of the WDUPS Al2O3 can be tailored in the range of meso- to macro-size by using different-sized microspheres to fabricate the SiO2 opal. The optimal amount of Al2O3 coating, which keeps the pore structure of SiO2 template intact, was determined to be of the 1-2 atomic layers. The surface acid amount of WDUPS Al2O3 significantly increased with the Al2O3 coating until one atomic layer formed. When the SiO2 opals were coated with optimal amount of Al2O3, the obtained WDUPS Al2O3 showed a uniform acid density. With these characteristics, the WDUPS Al2O3 support is ideal material for fundamental research in catalysis. The method is promising strategy to obtain other catalytic materials with the same structure. (C) 2013 Elsevier B.V. All rights reserved.
In this article, we construct the C circle times gamma C-mu and C gamma(5) circle times gamma(5)gamma C-mu type currents to interpolate the vector tetraquark states, then carry out the operator product expansion up to the vacuum condensates of dimension-10 in a consistent way, and obtain four QCD sum rules. In calculations, we use the formula mu =3D root M-Y(2) - (2M(c))(2) to determine the optimal energy scales of the QCD spectral densities, moreover, we take the experimental values of the masses of the Y(4260/4220), Y(4360/4320), Y(4390) and Y(4660/4630) as input parameters and fit the pole residues to reproduce the correlation functions at the QCD side. The numerical results support assigning the Y(4660/4630) to be the C circle times gamma C-mu type vector tetraquark state c (c) over bars (s) over bar, assigning the Y(4360/4320) to be C gamma(5) circle times gamma(5)gamma C-mu type vector tetraquark state c (c) over barq (q) over bar, and disfavor assigning the Y(4260/4220) and Y(4390) to be the pure vector tetraquark states.
In the present paper, we introduce and investigate a certain subclass of meromorphic close-to-convex functions. Such results as coefficient inequalities, convolution property, distortion property and radius of meromorphic convexity are derived. (C) 2011 Elsevier Ltd. All rights reserved.