A novel glycoluril scaffold 1, namely 1,6-(1,2-xylylene)-3,4-(1,3-dimetheneyl-hexahydropyrimidine)tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione, was synthesized by the Mannich reaction of 1,6-(1,2-xylylene)tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione 5 with propanediamine and paraformaldehyde. The yielded product 1 was confirmed with IR, NMR, EI-MS. X-ray crystallographic technique was also conducted and the result showed the crystal belongs to monoclinic system, space group P2(1)/c with unit cell parameters a = 10.6892(11) angstrom, b = 12.1226(9) angstrom, c = 13.7822(13) angstrom, alpha = 90 degrees, beta = 112.620(4)degrees,gamma = 90 degrees, V = 1648.5(3) angstrom(3), Z = 4, D-c = 1.428, M-r = 354.41, mu = 0.098 mm(-1), F(000) = 752, R-1 = 0.0522 and wR(2) = 0.1138. A novel molecular scaffold, containing a heterocyclic ring instead of an aromatic ring, was synthesized by the Mannich reaction based on glycoluril.
In this article, we take X(4140) as the diquark-antidiquark type cs (c) over bar(s) over bar tetraquark state with J(PC) =3D 1(++), and we study the mass and pole residue with the QCD sum rules in detail by constructing two types of interpolating currents. The numerical results M-XL,M-+ =3D 3.95 +/- 0.09 GeV and M-XH,M-+ =3D 5.00 +/- 0.10 GeV disfavor assigning the X(4140) to the J(PC) =3D 1(++) diquark-antidiquark type cs (c) over bar(s) over bar tetraquark state. Moreover, we obtain the masses of the J(PC) =3D 1(+-)diquark-antidiquark type cs (c) over bar(s) over bar s tetraquark states as a byproduct. The present predictions can be confronted to the experimental data in the future.
Single-virus tracking (SVT) technique, which uses microscopy to monitor the behaviors of viruses, is a vital tool to study the real-time and in situ infection dynamics and virus-related interactions in live cells. To make SVT a more versatile tool in biological research, the researchers have developed a quantum dot (QD)-based SVT technique, which can be utilized for long-term and highly sensitive tracking in live cells. In this review, we describe the development of a QD-based SVT technique and its biological applications. We first discuss the advantage of QDs as tags in the SVT field by comparing the conventional tags, and then focus on the implementation of QD-based SVT experiments, including the QD labeling strategy, instrumentation, and image analysis method. Next, we elaborate the recent advances of QD-based SVT in the biological field, and mainly emphasize the representative examples to show how to use this technique to acquire more meaningful biological information.
Liu, Zhi-Hong
Wang, Zhi-Gang
Rasila, Antti
Jiang, Yue-Ping
We prove that convolutions of harmonic right half-plane mappings with harmonic vertical strip mappings are univalent and convex in the horizontal direction. The proofs of these results make use the Gauss-Lucas Theorem. Our results show that two recent conjectures, the one by Kumar, Gupta, Singh and Dorff, and the one of Liu, Jiang and Li, are true. Moreover, examples of univalent harmonic mappings related to the above-mentioned results are presented, suggesting that the bounds given by our results may be sharp.
Based on the diquark configuration, we construct the diquark-antidiquark interpolating tetraquark currents with J(PC) =3D 1(-+/-) and 1(++/-), which can couple to the scalar and pseudoscalar tetraquark states, respectively, since they are not conserved currents. Then, we investigate their two-point correlation functions including the contributions of the vacuum condensates up to dimension-10 and extract the masses and pole residues of the tetraquark states with JPC =3D 0(++/-) and 0(-+/-) through the QCD sum rule approach. The predicted masses can be confronted with the experimental data in the future. Moreover, we briefly discuss the possible decay patterns of the tetraquark states.
Extracellular vesicles (EVs) can mediate intercellular communication by transferring cargo proteins and nucleic acids between cells. The pathophysiological roles and clinical value of EVs are under intense investigation, yet most studies are limited by technical challenges in the isolation of nanoscale EVs (nEVs). Here, we report a lipid-nanoprobe system that enables spontaneous labelling of nEVs for subsequent magnetic enrichment in 15 minutes, with isolation efficiency and cargo composition similar to what can be achieved by the much slower and bulkier method of ultracentrifugation. We also show that this approach allows for downstream analyses of nucleic acids and proteins, enabling the identification of EGFR and KRAS mutations following nEV isolation from the blood plasma of non-small-cell lung-cancer patients. The efficiency and versatility of the lipid-nanoprobe approach opens up opportunities in point-of-care cancer diagnostics.
In this paper, we tentatively assign the Z(c) (4600) to be the [dc] p[(u) over bar(c) over bar](A) - [dc](A)[(u) over bar(c) over bar](P) type vector tetraquark state and study its two-body strong decays with the QCD sum rules based on solid quark-hadron duality, the predictions for the partial decay widths Gamma(Z(c)(-) -> J/psi pi(-)) =3D 41.4(-1)(4.)(5)(+)(20.5) MeV, Gamma(Z(c)(-)> eta(c)rho(-)) =3D 41.6(-22.2)(+32.7) MeV, Gamma(Z(c)(-)-> J/psi a(0)(- )(980)) =3D 10.2(-6.7)(+1)(1.)(3) MeV, Gamma(Z(c)(-)+ chi(-)(c0)(rho)) =3D 3.5(-3.0)(+6.7) MeV, Gamma(Z(c)(-)-> D*(0) D*(-))=3D 39.5(-19.3)(+29.6) MeV, Gamma(Z(c)(-)-> (DD-)-D-0) =3D 6.6(-3.0)(+4.6) MeV and Gamma(Z(c)(-) -> D*(0) D-)=3D 1.0(-0.6)(+1.0) MeV can be compared to the experimental data in the future to diagnose the nature of the Z(c)(4600).
In this paper, we assume the Z(c)(4200) as the color octet-octet type axial-vector molecule-like state, and construct the color octet-octet type axial-vector current to study its mass and width with the QCD sum rules. The numerical values M-Zc(4200) =3D 4.19 +/- 0.08 GeV and Gamma(Zc)(4200) approximate to 334 MeV are consistent with the experimental data M-Zc(4200) =3D 4196(-29-13)(+31+17) MeV and Gamma(Zc)(4200) =3D 370(-70-132)(+70+70) MeV, and support assigning the Z(c)(4200) to be the color octet-octet type molecule-like state with J(PC) =3D (1+-). Furthermore, we discuss the possible assignments of the Z(c)(3900), Z(c)(4200) and Z(4430) as the diquark-antidiquark type tetraquark states with J(PC) =3D 1(+-).
In this paper, we tentatively assign the Y (4140), Y (4274) and X(4350) to be the scalar and tensor cs (c) over bar(s) over bar tetraquark states, respectively, and study them with the QCD sum rules. In the operator product expansion, we take into account the vacuum condensates up to dimension-10. In calculations, we use the formula mu =3D root M-X/Y/Z(2) - (2M(c))(2) to determine the energy scales of the QCD spectral densities. The numerical results favor assigning the Y (4140) to be the J(PC) =3D 2(++) diquark-antidiquark type tetraquark state, and disfavor assigning the Y (4274) and X (4350) to be the 0(++) or 2(++) tetraquark states.
In this paper, we tentatively assign the Y (4140), Y (4274) and X(4350) to be the scalar and tensor cs (c) over bar(s) over bar tetraquark states, respectively, and study them with the QCD sum rules. In the operator product expansion, we take into account the vacuum condensates up to dimension-10. In calculations, we use the formula mu = root M-X/Y/Z(2) - (2M(c))(2) to determine the energy scales of the QCD spectral densities. The numerical results favor assigning the Y (4140) to be the J(PC) = 2(++) diquark-antidiquark type tetraquark state, and disfavor assigning the Y (4274) and X (4350) to be the 0(++) or 2(++) tetraquark states.
In this article, we construct the color singlet-singlet-singlet interpolating current with I(J(P)) =3D (3/2)(1(-)) to study the D (D) over bar (*) K system through QCD sum rules approach. In calculations, we consider the contributions of the vacuum condensates up to dimension-16 and employ the formula mu =3D root M-X/Y/Z(2) -(2M(c))(2) to choose the optimal energy scale of the QCD spectral density. The numerical result M-z =3D 4.71(-0.11)(+0.19) GeV indicates that there exists a resonance state Z lying above the D (D) over bar (*) K threshold to saturate the QCD sum rules. This resonance state Z may be found by focusing on the channel J/Psi pi Kappa of the decay B -> J/Psi pi pi Kappa in the future.
In this article, we take the D-s3*(2860) and D-s1*(2860) as the 13D3 and 1(3)D(1) c (s) over bar states, respectively, and we study their strong decays with the heavy meson effective theory by including the chiral symmetry-breaking corrections. We can reproduce the experimental data Br(D-sJ*(2860) -> D*K) /Br (D-sJ* (2860) -> DK) =3D 1.10 +/- 0.15 +/- 0.19 with suitable hadronic coupling constants; the assignment of the D-sJ* (2860) as the D-s3*(2860) is favored, the chiral symmetry-breaking corrections are large. Furthermore, we obtain the analytical expressions of the decay widths, which can be confronted with the experimental data in the future to fit the unknown coupling constants. The predictions of the ratios among the decay widths can be used to study the decay properties of the D-s3*(2860) and D-s1*(2860) so as to identify them unambiguously. On the other hand, if the chiral symmetry-breaking corrections are small, the large ratio R =3D 1.10 +/- 0.15 +/- 0.19 requires that the D-sJ*(2860) consists of at least the four resonances, D-s1*(2860), D-s2*(2860), D-s2(*)'(2860), D-s3*(2860).