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Now showing items 1 - 16 of 155417

  • Prediction of Shigellosis outcomes in Israel using machine learning classifiers

    Adamker, G.   Holzer, T.   Karakis, I.   Amitay, M.   Anis, E.   Singer, S. R.   Barnett-Itzhaki, Z.  

    Shigellosis causes significant morbidity and mortality in developing and developed countries, mostly among infants and young children. The World Health Organization estimates that more than one million people die from Shigellosis every year. In order to evaluate trends in Shigellosis in Israel in the years 2002-2015, we analysed national notifiable disease reporting data. Shigella sonnei was the most commonly identified Shigella species in Israel. Hospitalisation rates due to Shigella flexenri were higher in comparison with other Shigella species. Shigella morbidity was higher among infants and young children (age 0-5 years old). Incidence of Shigella species differed among various ethnic groups, with significantly high rates of S. flexenri among Muslims, in comparison with Jews, Druze and Christians. In order to improve the current Shigellosis clinical diagnosis, we developed machine learning algorithms to predict the Shigella species and whether a patient will be hospitalised or not, based on available demographic and clinical data. The algorithms' performances yielded an accuracy of 93.2% (Shigella species) and 94.9% (hospitalisation) and may consequently improve the diagnosis and treatment of the disease.
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  • Keeping an Eye on Biology

    Singer, S. R.   Schwarz, J. A.   Manduca, C. A.   Fox, S. P.   Iverson, E. R.   Taylor, B. J.   Cannon, S. B.   May, G. D.   Maki, S. L.   Farmer, A. D.   Doyle, J. J.  

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  • Two Revolutions in Learning

    Singer, S. R.   Bonvillian, W. B.  

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  • Venturing Beyond Beans and Peas: What Can We Learn from Chamaecrista?

    Singer, S. R.   Maki, S. L.   Farmer, A. D.   Ilut, D.   May, G. D.   Cannon, S. B.   Doyle, J. J.  

    Expanding legume research beyond the model members of the subfamily Papilionoideae (papilionoids) is necessary if we wish to capture more of the diversity of the enormous, economically important legume family. Chamaecrista fasciculata is emerging as a nonpapilionoid model, belonging to the paraphyletic subfamily Caesalpinioideae within the mimosoid clade. Mimosoids diverged from the common ancestor of soybean (Glycine max), Medicago truncatula, and Lotus japonicus nearly 60 million years ago-nearly contemporaneously with the origin of legumes. There is growing interest within the legume community in C. fasciculata as a complementary legume model for a number of reasons, including phylogenetic position, nodulation within a clade of limited nodulating species, nonpapilionoid floral morphology, herbaceous growth habit, and tractability in laboratory and field settings. Whole-transcriptome sequencing (WTS) of C. fasciculata shoots, roots, and nodules, along with gene expression and single nucleotide polymorphism (SNP) profiling, provides community resources to address fundamental questions about legume evolution. A range of ecotypes, development of functional genomics tools, and an integration of research and undergraduate education leverage these genomic resources.
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  • The Eating Experience:Adaptive and Maladaptive Strategies of Older Adults with Tooth Loss

    Zelig, R.   Jones, V. M.   Touger-Decker, R.   Hoskin, E. R.   Singer, S. R.   Byham-Gray, L.   Radler, D. R.   Rothpletz-Puglia, P.  

    Objective: To explore the eating experience and eating-related quality of life (ERQOL) of community-dwelling older adults with tooth loss. Method: Nineteen older adults from the clinics of a northeast US dental school who met inclusion criteria (>65 y old, <20 teeth, and no dentures) composed the sample. For this mixed methods study, demographic characteristics, number and location of teeth, Mini Nutritional Assessment-Short Form score, and anthropometrics data were collected; semistructured interviews were conducted to collect in-depth information about the eating experience and ERQOL. The analysis was completed with NVivo 12 software (QSR International). Results: Participants' mean age was 71.3 y (SD =3D 5.2); 52.6% (n=3D 10) were women; 63.2% (n =3D 12) were Black or African American. The mean Mini Nutritional Assessment-Short Form score of 12.1 was reflective of normal nutrition status; 31.6% (n =3D 6) of patients were at risk for malnutrition or were malnourished. Fifteen percent (n =3D 3) were fully edentulous; 84.2% (n =3D 16) had 1 to 19 teeth (mean =3D 10.8, SD =3D 6.5). The 2 overarching themes identified were adaptive and maladaptive behavioral responses to tooth loss. Adaptive strategies included modification in food preparation and cooking methods, food texture selection, meal timing, and approaches to chewing. Maladaptive behaviors included food avoidance and limiting eating and smiling in front of others. Psychosocial factors, including finances, limited food choices and ERQOL, whereas the support of family and friends enhanced ERQOL according to participants. Conclusion: Older adults with tooth loss exhibit both adaptive and maladaptive behaviors that affect their eating experience, dietary intake, and ERQOL. While many expressed positive adaptive coping strategies, they also described maladaptive behaviors, including avoidance of healthy foods and limiting eating during social interactions, which may affect their nutritional status and overall health and well-being. Further research is needed to explore how duration and severity of tooth loss influence these behaviors and risk of malnutrition. Intoprofessional approaches are needed to support positive adaptation and coping with tooth loss. Knowledge Transfer Statement: The results of this study can be used by health professionals treating patients with tooth loss in an effort to improve their eating experience and eating-related quality of life. The findings provide data to support further studies and the need for evidence-based guidelines and educational materials to meet the unique needs of older adults with tooth loss.
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  • MADNESS AND RACIAL THEORY IN I. J. SINGER\"S\r THE FAMILY CARNOVSKY

    Gilman   Sander L.  

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  • Isaac Bashevis Singer\"s\r Satan in Goray\r and Bakhtin\"s Vision of the Carnivalesque

    Guzlowski   John  

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  • The City of the Great Singer: C. R. Ashbee’s Jerusalem

    Rapaport, Raquel  

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  • Editorial: On the 90\r th\r Birthday of S. Fred Singer

    Michaels, Patrick   Michaels, Patrick  

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  • Agamemnon\"s singer (\r od.\r 3.262–272)?

    Andersen   ?ivind  

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  • Floral determination in internode tissues of day-neutral tobacco first occurs many nodes below the apex

    Singer, S. R.   McDaniel, C. N.  

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  • PETER SINGER\"S STRENUOUS MORALITY

    Dore   Clement  

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  • Manet’s\r The Street Singer\r and the poets

    Dolan Therese  

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  • Transport of the Herbicide 3-Amino-1,2,4-Triazole by Cultured Tobacco Cells and Leaf Protoplasts

    Singer, S. R.   McDaniel, C. N.  

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  • A Tribute to the Remarkable S. Fred Singer

    Michaels, Patrick   Happer, William  

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  • Singer\"s typewriter and mine: reflections on Jewish culture

    Glinert   Lewis  

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