A biopharmaceutical manufacturing control system and associated methods are disclosed herein.

Embodiments are disclosed that relate to enforcement of user policies in a multi-user interactive computing environment by end user review. For example, one disclosed embodiment provides, on a computing device, a method comprising receiving a notification of a current policy controversy, and sending information regarding the current policy controversy to each end user reviewer of a plurality of end user reviewers, each end user reviewer being a member of an enforcement federation of a plurality of enforcement federations. The method further comprises receiving enforcement decisions from one or more responding end user reviewers of the plurality of end user reviewers, and if the enforcement decisions received meet an enforcement threshold, then automatically enforcing a policy rule.

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