Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 97 - 112 of 138613

  • Pharmacological rationale for tapentadol therapy: a review of new evidence

    Romualdi, Patrizia   Grilli, Mariagrazia   Canonico, Pier Luigi   Collino, Massimo   Dickenson, Anthony H  

    Download Collect
  • , by P. Singh

    Giselle Balfour  

    Download Collect
  • G226(P) Why Do We Review Children?

    Bhusari, G.   Gopinathan, S.   Banerjee, K.  

    Download Collect
  • G226(P) Why Do We Review Children?

    Bhusari, G.; Gopinathan, S.; Banerjee, K.  

    Download Collect
  • Systematic review of immunomodulatory therapies for hidradenitis suppurativa

    Lim, Shi Yu Derek; Oon, Hazel H  

    Background: Greater understanding of the roles of tumor necrosis factor-alpha, IL-1 beta, IL-10, and the IL-23/T-helper (Th) 17 and IL-12/Th1 pathways in immune dysregulation in moderate/severe hidradenitis suppurativa (HS) has helped in developing new regimens. We aim to review the use of different immunomodulatory therapies used to manage HS. Methods: A comprehensive literature search was conducted on the PubMed and Clinicaltrials.gov databases from 1 January 1947 to 31 December 2018. Only clinical trials, case reports, case series and retrospective analyses published in the English language were included. Results: Our search yielded 107 articles and 35 clinical trials, of which 15 are still ongoing. The tumor necrosis factor-a inhibitors adalimumab and infliximab were the most comprehensively studied agents. Published data from clinical trials support the efficacy of adalimumab, infliximab, anakinra, ustekinumab, bermekimab and apremilast but not etanercept and MEDI8968. Clinical trials for CJM112 have been completed, with results awaiting publication. Trials are underway for secukinumab, IFX-1, INCB054707 and bimekizumab. Biologics used in smaller cohorts include canakinumab, golimumab and rituximab. Most agents are well tolerated and demonstrate a good safety profile, with the most commonly reported adverse event being infections. Discussion and conclusions: To date, adalimumab is the only biologic which has been approved by the United States Food and Drug Administration for HS. However, other agents also show promise, with further trials underway to evaluate their efficacy, tolerability and safety profiles. Different clinical measurement scores and endpoints used to make direct comparison difficult. Longitudinal surveillance and pooled registry data are paramount to evaluate the long-term safety profile and efficacy of therapy.
    Download Collect
  • Visceral bed involvement in thromboangiitis obliterans: a systematic review

    Fakoor, Faezeh   Fazeli, Bahare  

    Download Collect
  • Advanced geometrical optics, by P. D. Lin

    Barry Johnson   R.  

    Download Collect
  • Approximation by (p, q)-Baskakov–Beta operators

    Malik, Neha   Gupta, Vijay  

    Download Collect
  • Recognition of PSL(2, p) x PSL(2, p) by its complex group algebra

    Khosravi, Behrooz   Momen, Zahra   Khosravi, Behnam   Khosravi, Bahman  

    It is proved that every quasisimple group except covers of the alternating groups is uniquely determined up to isomorphism by the structure of CL, the complex group algebra of L. One of the next natural groups to be considered are the characteristically simple groups. In this paper, as the first step in this investigation we prove that if p > 3 is an odd prime number, then PSL(2, p) x PSL(2, p) is uniquely determined by the structure of its complex group algebra.
    Download Collect
  • Les philosophes de l\"age de pierre, ou la vérité de la Genèse, coll. ? Pratiques théoriques ?by Alain Lameyre

    Review by: P. Amiet  

    Download Collect
  • Composts Vary in Their Effect on Soil P Pools and P Uptake by Wheat

    Verma, Suman Lata   Penfold, Chris  

    With diminishing world reserves of phosphorus (P) deposits and rising fertilizer prices, it is important to find alternate sources of P for crops. The aim of this research was to evaluate the effect of four different composts C1 (animal manure and straw), C2 (garden waste), C3 (wood chips and bark), and C4 (kitchen waste) on soil P pools and P uptake by wheat on 14, 28, and 72 days after compost application. The composts were applied as a 2.5 cm thick layer on the soil surface. During sampling, only the soil underlying compost was sampled. Soil pH and total organic carbon were not affected by the amendments. Soil respiration was significantly higher in compost-amended soils compared with the unamended soil except with C4 on day 72. Addition of composts increased plant growth, and P uptake being highest on day 72 with C1 and C4. With little effect on available P concentration on day 14, there was a conversion of organic P into inorganic P in the compost treatments suggesting net mineralization of organic P on day 28. On day 72, the concentrations of the less labile P forms were higher in the compost treatments compared with the unamended suggesting precipitation and fixation as well as synthesis of organic P. This study showed that mulching with composts having high available and total P concentrations can provide plants with P and also increase soil P concentrations which could reduce the fertilizer requirement for the following crop.
    Download Collect
  • Systematic review of immunomodulatory therapies for hidradenitis suppurativa

    Lim, Shi Yu Derek   Oon, Hazel H  

    Download Collect
  • 2012 P&C Election Review

    Willem O. Rijksen  

    Download Collect
  • Natural complexity: a modelling handbook by P. Charbonneau

    Sanjuán   Miguel A. F.  

    Download Collect
  • Natural complexity: a modelling handbook by P. Charbonneau

    Sanjuán, Miguel A. F.  

    Download Collect
  • Wearable supercapacitor self-charged by P(VDF-TrFE) piezoelectric separator

    Yao Lu[1,2]   Yuan Jiang   Zheng Lou   Ruilong Shi   Di Chen   Guozhen Shen  

    Flexible piezoelectric self-charging supercapacitors(PSCS)are capable of converting random mechanical energy directly into electric energy and providing sustainable power source for various wearable electronic devices.In this work,using PDMS-rGO/C hybrid membrane as the positive and negative electrodes,P(VDF-TrFE)film as the piezoseparator,a flexible and ultralight PSCS was developed to harvest the mechanical energy of human finger curvature and simultaneously store as chemical energy in supercapacitors.The PSCS can be efficiently charged from finger deformation in the presence of polarized P(VDF-TrFE)separator film.When the finger was bended to 90°,the fabricated PSCS achieved a potential window of 0.45 V with the discharging time of about 18.0 s,and a stable charging current of 6.4μA,providing a promising power solution to the next-generation self-powered wearable electronics system.
    Download Collect
2 3 4 5 6 7 8 9 10 11

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback