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Now showing items 1 - 16 of 28

  • An open-source framework for pulmonary fissure completeness assessment

    Nardelli, Pietro   Onieva, Jorge   Gerard, Sarah E.   Harmouche, Rola   Okajima, Yuka   Diaz, Alejandro A.   Washko, George   Estepar, Raul San Jose  

    We present an open-source framework for pulmonary fissure completeness assessment. Fissure incompleteness has been shown to associate with emphysema treatment outcomes, motivating the development of tools that facilitate completeness estimation. Generally, the task of fissure completeness assessment requires accurate detection of fissures and definition of the boundary surfaces separating the lung lobes. The framework we describe acknowledges a) the modular nature of fissure detection and lung lobe segmentation (lobe boundary detection), and b) that methods to address these challenges are varied and continually developing. It is designed to be readily deployable on existing lung lobe segmentation and fissure detection data sets. The framework consists of multiple components: a flexible quality control module that enables rapid assessment of lung lobe segmentations, an interactive lobe segmentation tool exposed through 3D Slicer for handling challenging cases, a flexible fissure representation using particles-based sampling that can handle fissure feature-strength or binary fissure detection images, and a module that performs fissure completeness estimation using voxel counting and a novel surface area estimation approach. We demonstrate the usage of the proposed framework by deploying on 100 cases exhibiting various levels of fissure completeness. We compare the two completeness level approaches and also compare to visual reads. The code is available to the community via github as part of the Chest Imaging Platform and a 3D Slicer extension module. (C) 2020 Elsevier Ltd. All rights reserved.
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  • Pulmonary vascular pruning in smokers with bronchiectasis

    Diaz, Alejandro A.   Maselli, Diego J.   Rahaghi, Farbod   Come, Carolyn E.   Yen, Andrew   Maclean, Erick S.   Okajima, Yuka   Martinez, Carlos H.   Yamashiro, Tsuneo   Lynch, David A.   Wang, Wei   Kinney, Gregory L.   Washko, George R.   San José Estépar, Raúl  

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  • Association Between Interstitial Lung Abnormalities and All-Cause Mortality

    Putman, Rachel K.   Hatabu, Hiroto   Araki, Tetsuro   Gudmundsson, Gunnar   Gao, Wei   Nishino, Mizuki   Okajima, Yuka   Dupuis, Josee   Latourelle, Jeanne C.   Cho, Michael H.   El-Chemaly, Souheil   Coxson, Harvey O.   Celli, Bartolome R.   Fernandez, Isis E.   Zazueta, Oscar E.   Ross, James C.   Harmouche, Rola   Estepar, Raul San Jose   Diaz, Alejandro A.   Sigurdsson, Sigurdur   Gudmundsson, Elias F.   Eiriksdottir, Gudny   Aspelund, Thor   Budoff, Matthew J.   Kinney, Gregory L.   Hokanson, John E.   Williams, Michelle C.   Murchison, John T.   MacNee, William   Hoffmann, Udo   O'Donnell, Christopher J.   Launer, Lenore J.   Harrris, Tamara B.   Gudnason, Vilmundur   Silverman, Edwin K.   O'Connor, George T.   Washko, George R.   Hunninghake, Gary M.  

    IMPORTANCE Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.OBJECTIVE To investigate whether interstitial lung abnormalities are associated with increased mortality.DESIGN, SETTING, AND POPULATION Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005 -December 2006).EXPOSURES Interstitial lung abnormality status as determined by chest CT evaluation.MAIN OUTCOMES AND MEASURES All-cause mortality over an approximate 3- to 9-year median follow-up time. Cause-of-death information was also examined in the AGES-Reykjavik cohort.RESULTS Interstitial lung abnormalities were present in 177 (7%) of the 2633 participants from FHS, 378 (7%) of 5320 from AGES-Reykjavik, 156 (8%) of 2068 from COPDGene, and in 157 (9%) of 1670 from ECLIPSE. Over median follow-up times of approximately 3 to 9 years, there were more deaths (and a greater absolute rate of mortality) among participants with interstitial lung abnormalities when compared with those who did not have interstitial lung abnormalities in the following cohorts: 7% vs 1% in FHS (6% difference [95% CI, 2% to 10%]), 56% vs 33% in AGES-Reykjavik (23% difference [95% CI, 18% to 28%]), and 11% vs 5% in ECLIPSE (6% difference [95% CI, 1% to 11%]). After adjustment for covariates, interstitial lung abnormalities were associated with a higher risk of death in the FHS (hazard ratio [HR], 2.7 [95% CI, 1]to 6.5]; P =3D .03), AGES-Reykjavik (HR, 1.3 [95% CI, 1.2 to 1.4]; P < .001), COPDGene (HR, 1.8 [95% CI, 1.1to 2.8]; P =3D .01), and ECLIPSE (HR, 1.4 [95% CI, 1]to 2.0]; P =3D .02) cohorts. In the AGES-Reykjavik cohort, the higher rate of mortality could be explained by a higher rate of death due to respiratory disease, specifically pulmonary fibrosis.CONCLUSIONS AND RELEVANCE In 4 separate research cohorts, interstitial lung abnormalities were associated with a greater risk of all-cause mortality. The clinical implications of this association require further investigation.
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  • Marathon-induced pulmonary edema of a patient with transient dyspnea.

    Miyazawa, Ryo   Morita, Yuka   Okajima, Yuka   Matsusako, Masaki   Kurihara, Yasuyuki  

    We report a case of a 31-year-old healthy man with marathon-induced pulmonary edema. Chest radiograph revealed pulmonary edema without cardiomegaly. Contrast-enhanced chest computed tomography (CT) revealed transient pulmonary edema without filling-defect in pulmonary arteries. As marathon running increases in popularity, radiologists and emergency physicians should be familiar with diagnosis of this entity on chest radiograph, avoiding unnecessary CT examination without additional clinical information. =20
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  • P300 component of event-related potentials in persons with asperger disorder.

    Iwanami, Akira   Okajima, Yuka   Ota, Haruhisa   Tani, Masayuki   Yamada, Takashi   Yamagata, Bun   Hashimoto, Ryuichiro   Kanai, Chieko   Takashio, Osamu   Inamoto, Atsuko   Ono, Taisei   Takayama, Yukiko   Kato, Nobumasa  

    In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.=20
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  • Assessment of Pulmonary Hypertension: What CT and MRI Can Provide

    Okajima, Yuka   Ohno, Yoshiharu   Washko, George R.   Hatabu, Hiroto  

    Rationales and Objectives: Pulmonary hypertension (PH) is a life-threatening condition, characterized by elevated pulmonary arterial pressure, which is confirmed based on invasive right heart catheterization (RHO). Noninvasive examinations may support diagnosis of PH before proceeding to RHO and play an important role in management and treatment of the disease. Although echocardiography is considered a standard tool in diagnosis, recent advances have made computed tomography (CT) and magnetic resonance (MR) imaging promising tools, which may provide morphologic and functional information. In this article, we review image-based assessment of PH with a focus on CT and MR imaging. Conclusions: CT may provide useful morphologic information for depicting PH and seeking for underlying diseases. With the accumulated technological advancement, CT and MRI may provide practical tools for not only morphologic but also functional assessment of patients with PH.
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  • Assessment of Pulmonary Hypertension

    Okajima, Yuka   Ohno, Yoshiharu   Washko, George R.   Hatabu, Hiroto  

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  • Bent bone dysplasia (BBD)-FGFR2 type:the radiologic manifestations in early gestation

    Handa, Atsuhiko   Okajima, Yuka   Izumi, Noriko   Yamanaka, Michiko   Kurihara, Yasuyuki  

    Bent bone dysplasia-fibroblast growth factor receptor 2 type (BBD-FGFR2) is a recently identified skeletal dysplasia caused by specific FGFR2 mutations, characterized by craniosynostosis and prenatal bowing of the long bones. Only a few cases have been published. We report an affected fetus terminated at 21 weeks of gestation. The clinical and radiologic manifestations mostly recapitulate previous descriptions; however we suggest additional hallmarks of this disorder in early gestation. These hallmarks include distinctive short, thick clavicles and wavy ribs, as well as vertebral bodies that showed striking anteroposterior shortening. Femoral fractures were also present in our case. Although craniosynostosis is a hallmark of the disease, clinicians should be aware that craniosynostosis might not be readily apparent on plain films early in gestation.
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  • Magnetic and dielectric properties of InFe(2)O(4), InFeCuO(4), and InGaCuO(4)

    Yoshii, Kenji   Ikeda, Naoshi   Okajima, Yuka   Yoneda, Yasuhiro   Matsuo, Yoji   Horibe, Yoichi   Mori, Shigeo  

    The magnetic and dielectric properties of InFe(2)O(4), InFeCuO(4), and InGaCuO(4) have been investigated. All these materials are isostructural with RFe(2)O(4) (R = Y, Ho-Lu), which shows ferroelectricity due to iron-valence ordering. InFe(2)O(4) exhibits ferrimagnetic ordering at T(C) similar to 242 K and a dielectric constant (epsilon) of similar to 10000 at around room temperature. These properties resemble those of RFe(2)O(4); the origins of the magnetic and dielectric phenomena are likely common in InFe(2)O(4) and RFe(2)O(4). From measurements of the other two materials, we found that both T(C) and epsilon are decreased in the order of InFe(2)O(4), InFeCuO(4), and InGaCuO(4). This result strongly supports the previously reported explanation based on an electron transfer between the Fe-site ions for the corresponding rare-earth systems. Therefore, we propose that the dielectric properties of the oxides isostructural with RFe(2)O(4) are plausibly governed by electron transfer; this situation is different from that of ordinary ferroelectrics and dielectrics, in which the displacement of cations and anions is important. In addition, InFeCuO(4) and InGaCuO(4) exhibit large epsilon values (epsilon > similar to 1500). In consideration of this property, we discuss the possible applications of these oxides.
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  • A comparison of visual and quantitative methods to identify interstitial lung abnormalities.

    Kliment, Corrine R   Araki, Tetsuro   Doyle, Tracy J   Gao, Wei   Dupuis, Josee   Latourelle, Jeanne C   Zazueta, Oscar E   Fernandez, Isis E   Nishino, Mizuki   Okajima, Yuka   Ross, James C   Estepar, Raul San Jose   Diaz, Alejandro A   Lederer, David J   Schwartz, David A   Silverman, Edwin K   Rosas, Ivan O   Washko, George R   O'Connor, George T   Hatabu, Hiroto   Hunninghake, Gary M  

    BACKGROUND: Evidence suggests that individuals with interstitial lung abnormalities (ILA) on a chest computed tomogram (CT) may have an increased risk to develop a clinically significant interstitial lung disease (ILD). Although methods used to identify individuals with ILA on chest CT have included both automated quantitative and qualitative visual inspection methods, there has been not direct comparison between these two methods. To investigate this relationship, we created lung density metrics and compared these to visual assessments of ILA.; METHODS: To provide a comparison between ILA detection methods based on visual assessment we generated measures of high attenuation areas (HAAs, defined by attenuation values between -600 and -250 Hounsfield Units) in >4500 participants from both the COPDGene and Framingham Heart studies (FHS). Linear and logistic regressions were used for analyses.; RESULTS: Increased measures of HAAs (in =E2=89=A5 10 % of the lung) were significantly associated with ILA defined by visual inspection in both cohorts (P < 0.0001); however, the positive predictive values were not very high (19 % in COPDGene and 13 % in the FHS). In COPDGene, the association between HAAs and ILA defined by visual assessment were modified by the percentage of emphysema and body mass index. Although increased HAAs were associated with reductions in total lung capacity in both cohorts, there was no evidence for an association between measurement of HAAs and MUC5B promoter genotype in the FHS.; CONCLUSION: Our findings demonstrate that increased measures of lung density may be helpful in determining the severity of lung volume reduction, but alone, are not strongly predictive of ILA defined by visual assessment. Moreover, HAAs were not associated with MUC5B promoter genotype.=20
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  • Fast and real-time observation of hydrogen absorption kinetics for palladium nanoparticles

    Matsumura, Daiju   Okajima, Yuka   Nishihata, Yasuo   Mizuki, Jun'ichiro  

    Structural change of Pd nanoparticles on aluminum oxide during hydrogen absorption reaction was directly observed by X-ray absorption fine structure with dispersive optics. Hydrogen pressure dependence of the expansion of the interatomic distance for Pd-Pd bonding in Pd nanoparticles was investigated by real-time-resolved and in situ observation with a rate of 50 Hz at room temperature. It has been revealed that the Pd nanoparticles show strong hydrogen pressure dependence of the reaction rate and the saturated interatomic distance for the hydrogen absorption. Determined reaction order implies that the rate of the hydrogen absorption reaction is limited by the surface dissociative adsorption step. (C) 2010 Elsevier B.V. All rights reserved.
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  • Pulmonary hyperpolarized noble gas MRI: recent advances and perspectives in clinical application.

    Liu, Zaiyi   Araki, Tetsuro   Okajima, Yuka   Albert, Mitchell   Hatabu, Hiroto  

    The invention of hyperpolarized (HP) noble gas MRI using helium-3 ((3)He) or xenon-129 ((129)Xe) has provided a new method to evaluate lung function. Using HP (3)He or (129)Xe for inhalation into the lung air spaces as an MRI contrast agent significantly increases MR signal and makes pulmonary ventilation imaging feasible. This review focuses on important aspects of pulmonary HP noble gas MRI, including the following: (1) functional imaging types, (2) applications for major pulmonary diseases, (3) safety considerations, and (4) future directions. Although it is still challenging to use pulmonary HP noble gas MRI clinically, the technology offers promise for the investigation of the microstructure and function of the lungs. Copyright =C2=A9 2014 Elsevier Ireland Ltd. All rights reserved.
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  • Adult Life-Course Trajectories of Lung Function and the Development of Emphysema:The CARDIA Lung Study

    Washko, George R.   Colangelo, Laura A.   Estepar, Raul San Jose   Ash, Samuel Y.   Bhatt, Surya P.   Okajima, Yuka   Liu, Kiang   Jacobs, David R., Jr.   Iribarren, Carlos   Thyagarajan, Bharat   Lewis, Cora E.   Kumar, Rajesh   Han, MeiLan K.   Dransfield, Mark T.   Carnethon, Mercedes R.   Kalhan, Ravi  

    BACKGROUND: Peak lung function and rate of decline predict future airflow obstruction and nonrespiratory comorbid conditions. Associations between lung function trajectories and emphysema have not been explored. METHODS: Using data from the population-based CARDIA Study, we sought to describe the prevalence of visually ascertained emphysema at multiple time points and contextualize its development based upon participant's adult life course measures of lung function. There were 3171 men and women enrolled at a mean age of 25 years, who underwent serial spirometric examinations through a mean age of 55 years. Trajectories for the change in percent-predicted forced expiratory volume in one second (FEV1) were determined by fitting a mixture model via maximum likelihood. Emphysema was visually identified on computed tomographic scans and its prevalence reported at mean ages of 40, 45, and 50 years. RESULTS: We identified 5 trajectories describing peak and change in FEV1: "Preserved Ideal," "Preserved Good," "Preserved Impaired," "Worsening," and "Persistently Poor." Ever smokers comprised part of all 5 trajectories. The prevalence of emphysema was 1.7% (n =3D 46; mean age of 40 years), 2.5% (n =3D 67; mean age of 45 years), and 7.1% (n =3D 189; mean age of 50 years). Of those with emphysema at a mean age of 50 years, 18.0% were never smokers. Worsening and poor lung health trajectories were associated with increased odds of future emphysema independent of chronic tobacco smoke exposure (odds ratio 5.06; confidence interval, 1.84-13.96; odds ratio 4.85; confidence interval, 1.43-16.44). CONCLUSIONS: Lower peak and accelerated decline in FEV1 are risk factors for future emphysema independent of smoking status. (C) 2019 Published by Elsevier Inc.
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  • Intracellular Lipid in Ovarian Thecomas Detected by Dual-Echo Chemical Shift Magnetic Resonance Imaging

    Okajima, Yuka   Matsuo, Yoshitomo   Tamura, Ayako   Irie, Hiroyuki   Nakazono, Takahiko   Hara, Yukiko   Suzuki, Koyu   Yamasaki, Fumio   Kudo, Sho   Saida, Yukihisa  

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  • Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities.

    Araki, Tetsuro   Nishino, Mizuki   Zazueta, Oscar E   Gao, Wei   Dupuis, Josee   Okajima, Yuka   Latourelle, Jeanne C   Rosas, Ivan O   Murakami, Takamichi   O'Connor, George T   Washko, George R   Hunninghake, Gary M   Hatabu, Hiroto  

    OBJECTIVE: To investigate the prevalence and distribution of paraseptal emphysema on chest CT images in the Framingham Heart Study (FHS) population, and assess its impact on pulmonary function. Also pursued was the association with interstitial lung abnormalities.; MATERIALS AND METHODS: We assessed 2633 participants in the FHS for paraseptal emphysema on chest CT. Characteristics of the participants, including age, sex, smoking status, clinical symptoms, and results of pulmonary function tests, were compared between those with and without paraseptal emphysema. The association between paraseptal emphysema and interstitial lung abnormalities was investigated.; RESULTS: Of the 2633 participants, 86 (3%) had pure paraseptal emphysema (defined as paraseptal emphysema with no other subtypes of emphysema other than paraseptal emphysema or a very few centrilobular emphysema involved) in at least one lung zone. The upper zone of the lungs was almost always involved. Compared to the participants without paraseptal emphysema, those with pure paraseptal emphysema were significantly older, and were more frequently male and smokers (mean 64 years, 71% male, mean 36 pack-years, P<0.001) and had significantly decreased FEV1/FVC% (P=3D0.002), and diffusion capacity of carbon monoxide (DLCO) (P=3D0.002). There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities (P<0.001).; CONCLUSIONS: The prevalence of pure paraseptal emphysema was 3% in the FHS population, predominantly affects the upper lung zone, and contributes to decreased pulmonary function. Cigarette smoking, aging, and male gender were the factors associated with the presence of paraseptal emphysema. Significant association between paraseptal emphysema and interstitial lung abnormalities was observed. Copyright =C2=A9 2015 Elsevier Ireland Ltd. All rights reserved.
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  • Luminal Plugging on Chest CT Scan Association With Lung Function,Quality of Life,and COPD Clinical Phenotypes

    Okajima, Yuka   Come, Carolyn E.   Nardelli, Pietro   Sonavane, Sushil K.   Yen, Andrew   Nath, Hrudaya P.   Terry, Nina   Grumley, Scott A.   Ahmed, Asmaa   Kligerman, Seth   Jacobs, Kathleen   Lynch, David A.   Make, Barry J.   Silverman, Edwin K.   Washko, George R.   Estepar, Raul San Jose   Diaz, Alejandro A.  

    BACKGROUND: Mucous exudates occluding the lumen of small airways are associated with reduced lung function and mortality in subjects with COPD; however, luminal plugs in large airways have not been widely studied. We aimed to examine the associations of chest CT scan-identified luminal plugging with lung function, health-related quality of life, and COPD phenotypes. METHODS: We randomly selected 100 smokers without COPD and 400 smokers with COPD from the COPDGene Study. Luminal plugging was visually identified on inspiratory CT scans at baseline and 5-year follow-up. The relationships of luminal plugging to FEV1, St. George's Respiratory Questionnaire (SGRQ) score, emphysema on CT scan (defined as the percentage of low attenuation area < 950 Hounsfield units [%LAA-950]), and chronic bronchitis were assessed using linear and logistic multivariable analyses. RESULTS: Overall, 111 subjects (22%) had luminal plugging. The prevalence of luminal plugging was higher in subjects with COPD than those without COPD (25% vs 10%, respectively; P =3D.001). In subjects with COPD, luminal plugging was significantly associated with FEV1 % predicted (estimate, -6.1; SE, 2.1; P =3D.004) and SGRQ score (estimate, 4.9; SE, 2.4; P =3D.04) in adjusted models. Although luminal plugging was associated with log %LAA-950 (estimate, 0.43; SE, 0.16; P =3D.007), its relationship with chronic bronchitis did not reach statistical significance (P =3D.07). Seventy-three percent of subjects with COPD with luminal plugging at baseline had it 5 years later. CONCLUSIONS: In subjects with COPD, CT-identified luminal plugging is associated with airflow obstruction, worse health-related quality of life, and emphysema phenotype. This imaging feature may supplement the current clinical assessment of chronic mucus hypersecretion in COPD.
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