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Now showing items 1 - 16 of 25

  • An open-source framework for pulmonary fissure completeness assessment

    Ross, James C.   Nardelli, Pietro   Onieva, Jorge   Gerard, Sarah E.   Harmouche, Rola   Okajima, Yuka   Diaz, Alejandro A.   Washko, George   San José Estépar, Raúl  

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  • Pulmonary vascular pruning in smokers with bronchiectasis

    Diaz, Alejandro A.   Maselli, Diego J.   Rahaghi, Farbod   Come, Carolyn E.   Yen, Andrew   Maclean, Erick S.   Okajima, Yuka   Martinez, Carlos H.   Yamashiro, Tsuneo   Lynch, David A.   Wang, Wei   Kinney, Gregory L.   Washko, George R.   San José Estépar, Raúl  

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  • Association Between Interstitial Lung Abnormalities and All-Cause Mortality

    Putman, Rachel K.   Hatabu, Hiroto   Araki, Tetsuro   Gudmundsson, Gunnar   Gao, Wei   Nishino, Mizuki   Okajima, Yuka   Dupuis, Josee   Latourelle, Jeanne C.   Cho, Michael H.   El-Chemaly, Souheil   Coxson, Harvey O.   Celli, Bartolome R.   Fernandez, Isis E.   Zazueta, Oscar E.   Ross, James C.   Harmouche, Rola   Estepar, Raul San Jose   Diaz, Alejandro A.   Sigurdsson, Sigurdur   Gudmundsson, Elias F.   Eiriksdottir, Gudny   Aspelund, Thor   Budoff, Matthew J.   Kinney, Gregory L.   Hokanson, John E.   Williams, Michelle C.   Murchison, John T.   MacNee, William   Hoffmann, Udo   O'Donnell, Christopher J.   Launer, Lenore J.   Harrris, Tamara B.   Gudnason, Vilmundur   Silverman, Edwin K.   O'Connor, George T.   Washko, George R.   Hunninghake, Gary M.  

    IMPORTANCE Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.OBJECTIVE To investigate whether interstitial lung abnormalities are associated with increased mortality.DESIGN, SETTING, AND POPULATION Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005 -December 2006).EXPOSURES Interstitial lung abnormality status as determined by chest CT evaluation.MAIN OUTCOMES AND MEASURES All-cause mortality over an approximate 3- to 9-year median follow-up time. Cause-of-death information was also examined in the AGES-Reykjavik cohort.RESULTS Interstitial lung abnormalities were present in 177 (7%) of the 2633 participants from FHS, 378 (7%) of 5320 from AGES-Reykjavik, 156 (8%) of 2068 from COPDGene, and in 157 (9%) of 1670 from ECLIPSE. Over median follow-up times of approximately 3 to 9 years, there were more deaths (and a greater absolute rate of mortality) among participants with interstitial lung abnormalities when compared with those who did not have interstitial lung abnormalities in the following cohorts: 7% vs 1% in FHS (6% difference [95% CI, 2% to 10%]), 56% vs 33% in AGES-Reykjavik (23% difference [95% CI, 18% to 28%]), and 11% vs 5% in ECLIPSE (6% difference [95% CI, 1% to 11%]). After adjustment for covariates, interstitial lung abnormalities were associated with a higher risk of death in the FHS (hazard ratio [HR], 2.7 [95% CI, 1]to 6.5]; P =3D .03), AGES-Reykjavik (HR, 1.3 [95% CI, 1.2 to 1.4]; P < .001), COPDGene (HR, 1.8 [95% CI, 1.1to 2.8]; P =3D .01), and ECLIPSE (HR, 1.4 [95% CI, 1]to 2.0]; P =3D .02) cohorts. In the AGES-Reykjavik cohort, the higher rate of mortality could be explained by a higher rate of death due to respiratory disease, specifically pulmonary fibrosis.CONCLUSIONS AND RELEVANCE In 4 separate research cohorts, interstitial lung abnormalities were associated with a greater risk of all-cause mortality. The clinical implications of this association require further investigation.
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  • Marathon-induced pulmonary edema of a patient with transient dyspnea.

    Miyazawa, Ryo   Morita, Yuka   Okajima, Yuka   Matsusako, Masaki   Kurihara, Yasuyuki  

    We report a case of a 31-year-old healthy man with marathon-induced pulmonary edema. Chest radiograph revealed pulmonary edema without cardiomegaly. Contrast-enhanced chest computed tomography (CT) revealed transient pulmonary edema without filling-defect in pulmonary arteries. As marathon running increases in popularity, radiologists and emergency physicians should be familiar with diagnosis of this entity on chest radiograph, avoiding unnecessary CT examination without additional clinical information. =20
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  • P300 component of event-related potentials in persons with asperger disorder.

    Iwanami, Akira   Okajima, Yuka   Ota, Haruhisa   Tani, Masayuki   Yamada, Takashi   Yamagata, Bun   Hashimoto, Ryuichiro   Kanai, Chieko   Takashio, Osamu   Inamoto, Atsuko   Ono, Taisei   Takayama, Yukiko   Kato, Nobumasa  

    In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.=20
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  • Assessment of Pulmonary Hypertension: What CT and MRI Can Provide

    Okajima, Yuka   Ohno, Yoshiharu   Washko, George R.   Hatabu, Hiroto  

    Rationales and Objectives: Pulmonary hypertension (PH) is a life-threatening condition, characterized by elevated pulmonary arterial pressure, which is confirmed based on invasive right heart catheterization (RHO). Noninvasive examinations may support diagnosis of PH before proceeding to RHO and play an important role in management and treatment of the disease. Although echocardiography is considered a standard tool in diagnosis, recent advances have made computed tomography (CT) and magnetic resonance (MR) imaging promising tools, which may provide morphologic and functional information. In this article, we review image-based assessment of PH with a focus on CT and MR imaging. Conclusions: CT may provide useful morphologic information for depicting PH and seeking for underlying diseases. With the accumulated technological advancement, CT and MRI may provide practical tools for not only morphologic but also functional assessment of patients with PH.
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  • Assessment of Pulmonary Hypertension

    Okajima, Yuka   Ohno, Yoshiharu   Washko, George R.   Hatabu, Hiroto  

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  • A comparison of visual and quantitative methods to identify interstitial lung abnormalities.

    Kliment, Corrine R   Araki, Tetsuro   Doyle, Tracy J   Gao, Wei   Dupuis, Josee   Latourelle, Jeanne C   Zazueta, Oscar E   Fernandez, Isis E   Nishino, Mizuki   Okajima, Yuka   Ross, James C   Estepar, Raul San Jose   Diaz, Alejandro A   Lederer, David J   Schwartz, David A   Silverman, Edwin K   Rosas, Ivan O   Washko, George R   O'Connor, George T   Hatabu, Hiroto   Hunninghake, Gary M  

    BACKGROUND: Evidence suggests that individuals with interstitial lung abnormalities (ILA) on a chest computed tomogram (CT) may have an increased risk to develop a clinically significant interstitial lung disease (ILD). Although methods used to identify individuals with ILA on chest CT have included both automated quantitative and qualitative visual inspection methods, there has been not direct comparison between these two methods. To investigate this relationship, we created lung density metrics and compared these to visual assessments of ILA.; METHODS: To provide a comparison between ILA detection methods based on visual assessment we generated measures of high attenuation areas (HAAs, defined by attenuation values between -600 and -250 Hounsfield Units) in >4500 participants from both the COPDGene and Framingham Heart studies (FHS). Linear and logistic regressions were used for analyses.; RESULTS: Increased measures of HAAs (in =E2=89=A5 10 % of the lung) were significantly associated with ILA defined by visual inspection in both cohorts (P < 0.0001); however, the positive predictive values were not very high (19 % in COPDGene and 13 % in the FHS). In COPDGene, the association between HAAs and ILA defined by visual assessment were modified by the percentage of emphysema and body mass index. Although increased HAAs were associated with reductions in total lung capacity in both cohorts, there was no evidence for an association between measurement of HAAs and MUC5B promoter genotype in the FHS.; CONCLUSION: Our findings demonstrate that increased measures of lung density may be helpful in determining the severity of lung volume reduction, but alone, are not strongly predictive of ILA defined by visual assessment. Moreover, HAAs were not associated with MUC5B promoter genotype.=20
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  • Magnetic and dielectric properties of InFe(2)O(4), InFeCuO(4), and InGaCuO(4)

    Yoshii, Kenji   Ikeda, Naoshi   Okajima, Yuka   Yoneda, Yasuhiro   Matsuo, Yoji   Horibe, Yoichi   Mori, Shigeo  

    The magnetic and dielectric properties of InFe(2)O(4), InFeCuO(4), and InGaCuO(4) have been investigated. All these materials are isostructural with RFe(2)O(4) (R = Y, Ho-Lu), which shows ferroelectricity due to iron-valence ordering. InFe(2)O(4) exhibits ferrimagnetic ordering at T(C) similar to 242 K and a dielectric constant (epsilon) of similar to 10000 at around room temperature. These properties resemble those of RFe(2)O(4); the origins of the magnetic and dielectric phenomena are likely common in InFe(2)O(4) and RFe(2)O(4). From measurements of the other two materials, we found that both T(C) and epsilon are decreased in the order of InFe(2)O(4), InFeCuO(4), and InGaCuO(4). This result strongly supports the previously reported explanation based on an electron transfer between the Fe-site ions for the corresponding rare-earth systems. Therefore, we propose that the dielectric properties of the oxides isostructural with RFe(2)O(4) are plausibly governed by electron transfer; this situation is different from that of ordinary ferroelectrics and dielectrics, in which the displacement of cations and anions is important. In addition, InFeCuO(4) and InGaCuO(4) exhibit large epsilon values (epsilon > similar to 1500). In consideration of this property, we discuss the possible applications of these oxides.
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  • Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice

    Matsuzaka, Takashi   Kuba, Motoko   Koyasu, Saori   Yamamoto, Yuta   Motomura, Kaori   Arulmozhiraja, Sundaram   Ohno, Hiroshi   Sharma, Rahul   Shimura, Takuya   Okajima, Yuka   Han, Song‐iee   Aita, Yuichi   Mizunoe, Yuhei   Osaki, Yoshinori   Iwasaki, Hitoshi   Yatoh, Shigeru   Suzuki, Hiroaki   Sone, Hirohito   Takeuchi, Yoshinori   Yahagi, Naoya   Miyamoto, Takafumi   Sekiya, Motohiro   Nakagawa, Yoshimi   Ema, Masatsugu   Takahashi, Satoru   Tokiwa, Hiroaki   Shimano, Hitoshi  

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  • Fast and real-time observation of hydrogen absorption kinetics for palladium nanoparticles

    Matsumura, Daiju   Okajima, Yuka   Nishihata, Yasuo   Mizuki, Jun'ichiro  

    Structural change of Pd nanoparticles on aluminum oxide during hydrogen absorption reaction was directly observed by X-ray absorption fine structure with dispersive optics. Hydrogen pressure dependence of the expansion of the interatomic distance for Pd-Pd bonding in Pd nanoparticles was investigated by real-time-resolved and in situ observation with a rate of 50 Hz at room temperature. It has been revealed that the Pd nanoparticles show strong hydrogen pressure dependence of the reaction rate and the saturated interatomic distance for the hydrogen absorption. Determined reaction order implies that the rate of the hydrogen absorption reaction is limited by the surface dissociative adsorption step. (C) 2010 Elsevier B.V. All rights reserved.
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  • Pulmonary hyperpolarized noble gas MRI: recent advances and perspectives in clinical application.

    Liu, Zaiyi   Araki, Tetsuro   Okajima, Yuka   Albert, Mitchell   Hatabu, Hiroto  

    The invention of hyperpolarized (HP) noble gas MRI using helium-3 ((3)He) or xenon-129 ((129)Xe) has provided a new method to evaluate lung function. Using HP (3)He or (129)Xe for inhalation into the lung air spaces as an MRI contrast agent significantly increases MR signal and makes pulmonary ventilation imaging feasible. This review focuses on important aspects of pulmonary HP noble gas MRI, including the following: (1) functional imaging types, (2) applications for major pulmonary diseases, (3) safety considerations, and (4) future directions. Although it is still challenging to use pulmonary HP noble gas MRI clinically, the technology offers promise for the investigation of the microstructure and function of the lungs. Copyright =C2=A9 2014 Elsevier Ireland Ltd. All rights reserved.
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  • Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities.

    Araki, Tetsuro   Nishino, Mizuki   Zazueta, Oscar E   Gao, Wei   Dupuis, Josee   Okajima, Yuka   Latourelle, Jeanne C   Rosas, Ivan O   Murakami, Takamichi   O'Connor, George T   Washko, George R   Hunninghake, Gary M   Hatabu, Hiroto  

    OBJECTIVE: To investigate the prevalence and distribution of paraseptal emphysema on chest CT images in the Framingham Heart Study (FHS) population, and assess its impact on pulmonary function. Also pursued was the association with interstitial lung abnormalities.; MATERIALS AND METHODS: We assessed 2633 participants in the FHS for paraseptal emphysema on chest CT. Characteristics of the participants, including age, sex, smoking status, clinical symptoms, and results of pulmonary function tests, were compared between those with and without paraseptal emphysema. The association between paraseptal emphysema and interstitial lung abnormalities was investigated.; RESULTS: Of the 2633 participants, 86 (3%) had pure paraseptal emphysema (defined as paraseptal emphysema with no other subtypes of emphysema other than paraseptal emphysema or a very few centrilobular emphysema involved) in at least one lung zone. The upper zone of the lungs was almost always involved. Compared to the participants without paraseptal emphysema, those with pure paraseptal emphysema were significantly older, and were more frequently male and smokers (mean 64 years, 71% male, mean 36 pack-years, P<0.001) and had significantly decreased FEV1/FVC% (P=3D0.002), and diffusion capacity of carbon monoxide (DLCO) (P=3D0.002). There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities (P<0.001).; CONCLUSIONS: The prevalence of pure paraseptal emphysema was 3% in the FHS population, predominantly affects the upper lung zone, and contributes to decreased pulmonary function. Cigarette smoking, aging, and male gender were the factors associated with the presence of paraseptal emphysema. Significant association between paraseptal emphysema and interstitial lung abnormalities was observed. Copyright =C2=A9 2015 Elsevier Ireland Ltd. All rights reserved.
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  • Intracellular Lipid in Ovarian Thecomas Detected by Dual-Echo Chemical Shift Magnetic Resonance Imaging

    Okajima, Yuka   Matsuo, Yoshitomo   Tamura, Ayako   Irie, Hiroyuki   Nakazono, Takahiko   Hara, Yukiko   Suzuki, Koyu   Yamasaki, Fumio   Kudo, Sho   Saida, Yukihisa  

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  • Luminal plugging on chest CT: association with lung function, quality of life, and COPD clinical phenotypes.

    Okajima, Yuka   Come, Carolyn E.   Nardelli, Pietro   Sonavane, Sushil K.   Yen, Andrew   Nath, Hrudaya P.   Terry, Nina   Grumley, Scott A.   Ahmed, Asmaa   Kligerman, Seth   Jacobs, Kathleen   Lynch, David A.   Make, Barry J.   Silverman, Edwin K.   Washko, George R.   San José Estépar, Raúl   Diaz, Alejandro A.  

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  • Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy

    Iwanami, Akira   Okajima, Yuka   Ota, Haruhisa   Tani, Masayuki   Yamada, Takashi   Hashimoro, Ryuichiro   Kanai, Chieko   Watanabe, Hiromi   Yamasue, Hidenori   Kawakubo, Yuki   Kato, Nobumasa  

    Dysfunction of the prefrontal cortex has been previously reported in individuals with Asperger's disorder. In the present study, we used multi-channel near-infrared spectroscopy (NIRS) to detect changes in the oxygenated hemoglobin concentration ([oxy-Hb]) during two verbal fluency tasks. The subjects were 20 individuals with Asperger's disorder and 18 age- and IQ-matched healthy controls. The relative [oxy-Hb] in the prefrontal cortex was measured during the category and letter fluency tasks. The mean total [oxy-Hb] during the category fluency task did not differ significantly between the groups; however, during the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. These results suggested task-relevant or task-specific prefrontal dysfunction in persons with Asperger's disorder. (C) 2011 Elsevier Ltd. All rights reserved.
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