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Now showing items 1 - 16 of 64

  • Parental stress in pediatric epilepsy after therapy withdrawal

    Operto, Francesca Felicia   Mazza, Roberta   Pastorino, Grazia Maria Giovanna   Campanozzi, Stella   Margari, Lucia   Coppola, Giangennaro  

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  • Psychogenic nonepileptic seizures in pediatric population: A review

    Operto, Francesca Felicia   Coppola, Giangennaro   Mazza, Roberta   Pastorino, Grazia Maria Giovanna   Campanozzi, Stella   Margari, Lucia   Roccella, Michele   Marotta, Rosa   Carotenuto, Marco  

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  • Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up

    Operto, Francesca Felicia   Pastorino, Grazia Maria Giovanna   Mazza, Roberta   Roccella, Michele   Carotenuto, Marco   Margari, Lucia   Verrotti, Alberto  

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  • Prognostic Indicators in Pediatric Clinically Isolated Syndrome

    Iaffaldano, Pietro   Simone, Marta   Lucisano, Giuseppe   Ghezzi, Angelo   Coniglio, Gabriella   Morra, Vincenzo Brescia   Salemi, Giuseppe   Patti, Francesco   Lugaresi, Alessandra   Izquierdo, Guillermo   Bergamaschi, Roberto   Cabrera-Gomez, Jose Antonio   Pozzilli, Carlo   Millefiorini, Enrico   Alroughani, Raed   Boz, Cavit   Pucci, Eugenio   Zimatore, Giovanni Bosco   Sola, Patrizia   Lus, Giacomo   Maimone, Davide   Avolio, Carlo   Cocco, Eleonora   Sajedi, Seyed Aidin   Costantino, Gianfranco   Duquette, Pierre   Shaygannejad, Vahid   Petersen, Thor   Fernandez Bolanos, Ricardo   Paolicelli, Damiano   Tortorella, Carla   Spelman, Tim   Margari, Lucia   Amato, Maria Pia   Comi, Giancarlo   Butzkueven, Helmut   Trojano, Maria  

    Objective: To assess prognostic factors for a second clinical attack and a first disability-worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods: A cohort of 770 pCIS patients was followed up for at least 10 years. Cox proportional hazard models and Recursive Partitioning and Amalgamation (RECPAM) tree-regression were used to analyze data. Results: In pCIS, female sex and a multifocal onset were risk factors for a second clinical attack (hazard ratio [HR], 95% confidence interval [CI] =3D 1.28, 1.06-1.55; 1.42, 1.10-1.84, respectively), whereas disease-modifying drug (DMD) exposure reduced this risk (HR, 95% CI =3D 0.75, 0.60-0.95). After pediatric onset MS (POMS) diagnosis, age at onset younger than 15 years and DMD exposure decreased the risk of a first Expanded Disability Status Scale (EDSS)-worsening event (HR, 95% CI =3D 0.59, 0.42-0.83; 0.75, 0.71-0.80, respectively), whereas the occurrence of relapse increased this risk (HR, 95% CI =3D 5.08, 3.46-7.46). An exploratory RECPAM analysis highlighted a significantly higher incidence of a first EDSS-worsening event in patients with multifocal or isolated spinal cord or optic neuritis involvement at onset in comparison to those with an isolated supratentorial or brainstem syndrome. A Cox regression model including RECPAM classes confirmed DMD exposure as the most protective factor against EDSS-worsening events and relapses as the most important risk factor for attaining EDSS worsening. Interpretation: This work represents a step forward in identifying predictors of unfavorable course in pCIS and POMS and supports a protective effect of early DMD treatment in preventing MS development and disability accumulation in this population.
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  • Long-term outcome of epilepsy in patients with Prader-Willi syndrome.

    Verrotti, Alberto   Cusmai, Raffaella   Laino, Daniela   Carotenuto, Marco   Esposito, Maria   Falsaperla, Raffaele   Margari, Lucia   Rizzo, Renata   Savasta, Salvatore   Grosso, Salvatore   Striano, Pasquale   Belcastro, Vincenzo   Franzoni, Emilio   Curatolo, Paolo   Giordano, Lucio   Freri, Elena   Matricardi, Sara   Pruna, Dario   Toldo, Irene   Tozzi, Elisabetta   Lobefalo, Lucio   Operto, Francesca   Altobelli, Emma   Chiarelli, Francesco   Spalice, Alberto  

    Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi syndrome patients suffering from epilepsy. We retrospectively studied 38 patients with Prader-Willi syndrome and seizures. Results of neuroimaging studies were obtained for 35 individuals. We subdivided these patients into two groups: group A, 24 patients, without brain lesions; and group B, 11 patients, with brain abnormalities. All patients were re-evaluated after a period of at least 10 years. Twenty-one patients (55.2 %) were affected by generalized epilepsy and 17 patients (44.8 %) presented focal epilepsy. The most common seizure type was generalized tonic-clonic seizure. The mean age at seizure onset was 4.5 years (ranged from 1 month to 14 years). In the follow-up period, seizure freedom was achieved in 32 patients (84.2 %). Seizure freedom was associated with electroencephalographic normalization, while the six children presenting drug-resistant epilepsy showed persistence of electroencephalographic abnormalities. Group B patients showed a higher prevalence of drug-resistant epilepsy. Patients with Prader-Willi syndrome were frequently affected by generalized seizures. Most of the patients had a favorable evolution, although, patients with brain abnormalities presented a worse outcome, suggesting that the presence of these lesions can influence the response to antiepileptic therapy.=20
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  • Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD.

    Toto, Maddalena   Margari, Francesco   Simone, Marta   Craig, Francesco   Petruzzelli, Maria Giuseppina   Tafuri, Silvio   Margari, Lucia  

    OBJECTIVE: An association between streptococcal infections, ABGA positivity, and no comorbidity ADHD (nc-ADHD) has been little investigated. The aim of this study was to evaluate the streptococcal infection frequency, defined entitled serum antistreptolysin O (ASO), and frequency of serum ABGA positivity in a sample of patients with nc-ADHD.; METHOD: In all 40 participants were investigated the ASO titer and ABGA.; RESULTS: The results showed that ABGA positivity was statistically significantly higher in patients affected by ADHD than in patients of a control group, and pathological values of ASO were statistically more frequent in the ADHD group than the control group.; CONCLUSION: These data suggest that streptococcal infections and autoimmune reactions against the basal ganglia are more frequent in ADHD patients than patients in a control group. =C2=A9 The Author(s) 2012.
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  • Electroclinical features of epilepsy monosomy 1p36 syndrome and their implications.

    Verrotti, Alberto   Greco, Marco   Varriale, Gaia   Tamborino, Agnese   Savasta, Salvatore   Carotenuto, Marco   Elia, Maurizio   Operto, Francesca   Margari, Lucia   Belcastro, Vincenzo   Selicorni, Angelo   Freri, Elena   Matricardi, Sara   Granata, Tiziana   Ragona, Francesca   Capovilla, Giuseppe   Spalice, Alberto   Coppola, Giangennaro   Striano, Pasquale  

    OBJECTIVIES: Monosomy 1p36 syndrome is a recognized syndrome with multiple congenital anomalies; medical problems of this syndrome include developmental delay, facial dysmorphisms, hearing loss, short stature, brain anomalies, congenital heart defects. Epilepsy can be another feature but there are few data about the types of seizures and long term prognosis. The aim of this work was to analyse the electroclinical phenotype and the long-term outcome in patients with monosomy 1p36 syndrome and epilepsy.; MATERIALS AND METHODS: Data of 22 patients with monosomy 1p36 syndrome and epilepsy were reconstructed by reviewing medical records. For each patient we analysed age at time of diagnosis, first signs of the syndrome, age at seizure onset, seizure type and its frequency, EEG and neuroimaging findings, the response to antiepileptic drugs treatment and clinical outcome up to the last follow-up assessment.; RESULTS: Infantile Spasm (IS) represents the most frequent type at epilepsy onset, which occurs in 36.4% of children, and a half of these were associated with hypsarrhythmic electroencephalogram. All patients with IS had persistence of seizures, unlike other patients with different seizures onset. Children with abnormal brain neuroimaging have a greater chance to develop pharmacoresistant epilepsy.; CONCLUSION: This syndrome represents a significant cause of IS: these patients, who develop IS, can suffer from pharmacoresistent epilepsy, that is more frequent in children with brain abnormalities. =C2=A9 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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  • Neuropsychopathological comorbidities in learning disorders

    Margari, Lucia   Buttiglione, Maura   Craig, Francesco   Cristella, Arcangelo   de Giambattista, Concetta   Matera, Emilia   Operto, Francesca   Simone, Marta  

    Background: Learning Disorders (LD) are complex diseases that affect about 2-10% of the school-age population. We performed neuropsychological and psychopathological evaluation, in order to investigate comorbidity in children with LD. Methods: Our sample consisted of 448 patients from 7 to 16 years of age with a diagnosis of LD, divided in two subgroups: Specific Learning Disorders (SLD), including reading, writing, mathematics disorders, and Learning Disorders Not Otherwise Specified (LD NOS). Results: Comorbidity with neuropsychopathologies was found in 62.2% of the total sample. In the LSD subgroup, ADHD was present in 33%, Anxiety Disorder in 28.8%, Developmental Coordination Disorder in 17.8%, Language Disorder in 11% and Mood Disorder in 9.4% of patients. In LD NOS subgroup, Language Disorder was present in 28.6%, Developmental Coordination Disorder in 27.5%, ADHD in 25.4%, Anxiety Disorder in 16.4%, Mood Disorder in 2.1% of patients. A statistically significant presence was respectively found for Language and Developmental Coordination Disorder comorbidity in LD NOS and for ADHD, mood and anxiety disorder comorbidity in SLD subgroup. Conclusions: The different findings emerging in this study suggested to promote further investigations to better define the difference between SLD and LD NOS, in order to improve specific interventions to reduce the long range consequences.
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  • Neuropsychopathological comorbidities in learning disorders

    Margari, Lucia   Buttiglione, Maura   Craig, Francesco   Cristella, Arcangelo   de Giambattista, Concetta   Matera, Emilia   Operto, Francesca   Simone, Marta  

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  • Ophthalmoplegic migraine: Migraine or oculomotor neuropathy?

    Margari, Lucia   Legrottaglie, Anna R.   Craig, Francesco   Petruzzelli, Maria G.   Procoli, Ugo   Dicuonzo, Franca  

    Background: Ophthalmoplegic migraine (OM) is a rare condition characterized by the association of headaches and an oculomotor nerve palsy. The third cranial nerve is commonly involved in recurrent attacks, whereas involvement of the sixth and fourth nerves is uncommon. It is still debated whether an uncontrolled migraine or an oculomotor neuropathy may be the primary cause of ophthalmoplegic migraine. Cases: We report two patients affected by OM with normal magnetic resonance imaging findings and a history of uncontrolled migraine before an attack of OM. Conclusion: The cases reported allow us to hypothesize that OM may be considered a form of migraine rather than a cranial neuralgia. It is possible that different factors such as inflammatory or structural factors, may represent a vulnerability of the nerve during a severe migraine attack causing ophthalmoplegia.
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  • Parenting stress and emotional/Behavioral Problems in adolescents with Primary headache

    Operto, Francesca Felicia   Craig, Francesco   Peschechera, Antonia   Mazza, Roberta   Lecce, Paola Alessandra   Margari, Lucia  

    Primary headache is a frequent and disabling disorder, common among children and adolescents, and it is a painful syndrome often accompanied by functional impairment and associated with emotional and behavior problems. The aim of this study was to investigate parenting stress and emotional/behavioral problems in adolescents affected by primary headache compared with healthy adolescents. The study population consisted of 35 adolescents and a control group of 23 healthy subjects. The assessment included the administration of clinical standardized scales such as Parent Stress Index-Short Form, Pediatric Migraine Disability Assessment Score Questionnaire, and Child Behavior Checklist (CBCL). Headache group and control group did not differ in terms of parenting stress (p =3D 0.29). On the contrary, headache group showed more internalizing problems (p =3D 0.023), affective problems (p =3D 0.01), anxious (p =3D 0.001), and somatic complaints (p < 0.001) compared with control group. In addition, we found a significant correlation between PSI domains and specific CBCL subscales in the headache group. The findings emphasize the need for expanded intervention in the clinical treatment of pediatric headache, a treatment that may also include the family members. Further research is needed.
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  • DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient

    Ruggieri, Simona   Viggiano, Luigi   Annese, Tiziana   Rubolino, Carmela   Gerbino, Andrea   De Zio, Roberta   Corsi, Patrizia   Tamma, Roberto   Ribatti, Domenico   Errede, Mariella   Operto, Francesca   Margari, Lucia   Resta, Nicoletta   Di Tommaso, Silvia   Rosati, Jessica   Trojano, Maria   Nico, Beatrice  

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  • Targets for Drug Therapy for Autism Spectrum Disorder:Challenges and Future Directions

    Lacivita, Enza   Perrone, Roberto   Margari, Lucia   Leopoldo, Marcello  

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and interaction and restricted, repetitive patterns of behavior, interests, and activities. Various factors are involved in the etiopathogenesis of ASD, including genetic factors, environmental toxins and stressors, impaired immune responses, mitochondrial dysfunction, and neuroinflammation. The heterogeneity in the phenotype among ASD patients and the complex etiology of the condition have long impeded the advancement of the development of pharmacological therapies. In the recent years, the integration of findings from mouse models to human genetics resulted in considerable progress toward the understanding of ASD pathophysiology. Currently, strategies to treat core symptoms of ASD are directed to correct synaptic dysfunctions, abnormalities in central oxytocin, vasopressin, and serotonin neurotransmission, and neuroinflammation. Here, we present a survey of the studies that have suggested molecular targets for drug development for ASD and the state-of-the-art of medicinal chemistry efforts in related areas.
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  • Clinical manifestations in children and adolescents with corpus callosum abnormalities

    Margari, Lucia   Palumbi, Roberto   Campa, Maria Gloria   Operto, Francesca Felicia   Buttiglione, Maura   Craig, Francesco   Matricardi, Sara   Verrotti, Alberto  

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  • Gelastic seizures not associated with hypothalamic hamartoma: A long-term follow-up study

    Iapadre, Giulia   Zagaroli, Luca   Cimini, Nicola   Belcastro, Vincenzo   Concolino, Daniela   Coppola, Giangennaro   Del Giudice, Ennio   Farello, Giovanni   Iezzi, Maria Laura   Margari, Lucia   Matricardi, Sara   Orsini, Alessandro   Parisi, Pasquale   Piccioli, Marta   Di Donato, Giulia   Savasta, Salvatore   Siliquini, Sabrina   Spalice, Alberto   Striano, Salvatore   Striano, Pasquale   Verrotti, Alberto  

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  • Aggressive behavior, cognitive impairment, and depressive symptoms in elderly subjects

    Margari, Lucia  

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