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Now showing items 1 - 16 of 44518

  • Hepatocellular carcinoma in cystic fibrosis liver disease:a cautionary tale

    O'Brien, C.   Ramlaul, N.   Haughey, A.   Nolan, N.   Malone, D. E.   McCormick, P. A.  

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  • CT colonography and transient bacteraemia: implications for antibiotic prophylaxis

    Ridge, C. A.   Carter, M. R.   Browne, L. P.   Ryan, R.   Hegarty, C.   Schaffer, K.   Malone, D. E.  

    Objectives To determine the prevalence of transient bacteraemia after CT colonography (CTC). Methods Blood cultures were obtained at 5, 10 and 15 min after CTC from 100 consecutive consenting patients. Blood samples were cultured in both aerobic and anaerobic media and positive blood culture samples were analysed by a microbiologist. Results Blood culture samples were positive for growth in sixteen patients. All positive blood culture samples were confirmed skin contaminants. There were no cases of significant bacteraemia. The estimated significant bacteraemia rate as a result of CTC is 0-3.7%, based on 95% confidence intervals around extreme results using Wilson's score method. Conclusions American Heart Association and National Institute for Clinical Excellence guidelines advise that antibiotic prophylaxis before lower gastrointestinal endoscopy is not indicated in patients with at risk cardiac lesions (ARCL) as the risk of a transient bacteraemia leading to infective endocarditis is low. These data show that the prevalence of transient bacteraemia after CTC is also low. It follows that patients with ARCL do not require antibiotic prophylaxis before CTC.
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  • Is diffusion-weighted MRI sufficient for follow-up of neuroendocrine tumour liver metastases?

    Lavelle, L. P.   O'Neill, A. C.   McMahon, C. J.   Cantwell, C. P.   Heffernan, E. J.   Malone, D. E.   Daly, L.   Skehan, S. J.  

    AIM: To assess if diffusion-weighted imaging (DWI) alone could be used for follow-up of neuroendocrine hepatic metastases. MATERIAL AND METHODS: This was a retrospective study, approved by the institutional review board. Twenty-two patients with neuroendocrine liver metastases who had undergone more than one liver magnetic resonance imaging (MRI) examination, (including DWI and using hepatocyte-specific contrast medium) were evaluated. Up to five metastases were measured at baseline and at each subsequent examination. The reference standard measurement was performed on the hepatocyte phase by one reader. Three independent readers separately measured the same lesions on DWI sequences alone, blinded to other sequences, and recorded the presence of any new lesions. RESULTS: The longest diameters of 317 liver metastases (91 on 22 baseline examinations and a further 226 measurements on follow-up) were measured on the reference standard by one reader and on three b-values by three other readers. The mean difference between DWI measurements and the reference standard measurement was between 0.01-0.08 cm over the nine reader/b-value combinations. Based on the width of the Bland and Altman interval containing approximately 95% of the differences between the reader observation and the mean of reference standard and DWI measurement, the narrowest interval over the nine reader/b-value combinations was -0.6 to +0.7 cm and the widest was -0.9 to 1 cm. In the evaluation of overall response using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria, the weighted kappa statistic was between 0.49 and 0.86, indicating moderate-to-good agreement between the reference standard and DWI. CONCLUSION: The visualisation and measurement of hepatic metastases using DWI alone are within acceptable limits for clinical use, allowing the use of this rapid technique to restage hepatic disease in patients with neuroendocrine metastases. (C) 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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  • Plain X-ray and computed tomography of the orbit in cases and suspected cases of intraocular foreign body

    Cassidy, L.   Malone, D. E.   Beatty, S.  

    Aim To evaluate the roles of plain X-ray and computed tomography (CT) orbital imaging in cases and suspected cases of intraocular foreign body (IOFB).Methods Retrospective review of clinical and radiological data relating to 204 consecutive cases and suspected cases of IOFB.Setting Royal Victoria Eye and Ear Hospital, Dublin, Ireland.Results Plain X-rays were performed in the absence of clinically evident ocular penetration in 177 (87%) cases, and no IOFB was demonstrated in any of these radiographs. Twenty-seven (13%) plain X-ray radiographs were obtained in the presence of clinically evident ocular penetration, and an IOFB was clinically visible in 19 (70%) of these cases. CT scans were undertaken in 21 (10%) of the 204 patients. Of these CT images, 9 (43%) and 12 (57%) were undertaken in the absence and presence of clinically evident ocular penetration, respectively. None (0%) and all (100%) of the CT scans obtained in the absence and presence of clinically evident ocular penetration demonstrated an IOFB, respectively.Conclusion Plain X-ray and CT orbital imaging are non-contributory in the absence of clinically evident ocular penetration. In the presence of clinically evident ocular penetration, and where an IOFB is clinically visible, plain X-ray orbital radiography may have a role in excluding multiple IOFBs. In the presence of clinically evident ocular penetration, but where an IOFB is not clinically visible, CT orbital imaging remains the investigation of choice, and the role of pre-CT plain X-ray orbital radiography, as recommended by the guidelines of the Royal College of Radiologists, merits re-evaluation.
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  • Peptic Ulcer in Rheumatoid Arthritis

    MALONE, D. E.   McCORMICK, P. A.   DALY, L.   BRESNIHAN, B.   O\"DONOGHUE, D. P.  

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  • PEPTIC ULCER IN RHEUMATOID ARTHRITIS-INTRINSIC OR RELATED TO DRUG THERAPY?

    MALONE, D. E.   McCORMICK, P. A.   DALY, L.   JONES, B.   LONG, A.   BRESNIHAN, B.   MOLONY, J.   O\"DONOGHUE, D. P.  

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  • Fiedler, E. D. (2015)

    Renée Schuster  

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  • Domande (D) e Risposte (R)

    Cai Tommaso  

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  • D - H || Artikelstrecke E / Article Stretch E

    Wiegand, Herbert Ernst   Bei?wenger, Michael   Gouws, Rufus Hjalmar   Kammerer, Matthias   Mann, Michael   Storrer, Angelika   Wolski, Werner  

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  • D - H || Artikelstrecke E / Article Stretch E

    Wiegand, Herbert Ernst; Beißwenger, Michael; Gouws, Rufus Hjalmar; Kammerer, Matthias; Mann, Michael; Storrer, Angelika; Wolski, Werner  

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  • . By E. D. Hirsch, Jr.

    Jan Derry  

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  • Calcio, vitamina D e fratture: domande e risposte

    Brandi ML  

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  • S Q E D (4) and Q E D (4) on the Null-Plane

    Casana, R.   Pimentel, B. M.   Zambrano, G. E. R.  

    We study the scalar electrodynamics (S Q E D (4)) and the spinor electrodynamics (Q E D (4)) in the null-plane formalism. We follow Dirac's technique for constrained systems to analyze the constraint structure in both theories in detail. We impose the appropriate boundary conditions on the fields to fix the hidden subset first class constraints that generate improper gauge transformations and obtain a unique inverse of the second-class constraint matrix. Finally, choosing the null-plane gauge condition, we determine the generalized Dirac brackets of the independent dynamical variables, which via the correspondence principle give the (anti)-commutators for posterior quantization.
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  • Metrics to Evaluate R,D&E

    John R. Hauser;Florian Zettelmeyer;  

    Metrics affect research decisions, research efforts, and the researchers themselves. From a review of the literature, interviews at ten research-intensive organizations, and formal mathematical analyses, the authors conclude that the best metrics depend upon the goals of the R,D&E activity as they vary from applied projects to competency-building programs to basic research explorations. For applied projects, market outcome metrics (sales, customer satisfaction, margins, profit) are relevant if they are adjusted via corporate subsidies to account for short-termism, risk aversion, scope, and options thinking. The magnitude of the subsidy should vary by project according to a well-defined formula. For R,D&E programs that match or create core technological competence, outcome metrics must be moderated with “effort” metrics. Too large a weight on market outcomes leads to false rejection of promising programs. The large weight encourages the selection of lesser-value programs that provide short-term, certain results concentrated in a few business units. This, in turn, leads a firm to use up its “research stock.” Instead, to align R,D&E with the goals of the firm, the metric system should balance market outcome metrics with metrics that attempt to measure research effort more directly. Such metrics include many traditional indicators. For long-term research explorations, the right metrics encourage a breadth of ideas. For example, many firms seek to identify their “best people” by rewarding them for successful completion of research explorations. However, metrics implied by this practice lead directly to “not-invented-here” attitudes and result in research empires that are larger than necessary but lead to fewer total ideas. Alternatively, by using metrics that encourage “research tourism,” the firm can take advantage of the potential for research spillovers and be more profitable.
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  • Corporate Litigation || E. D&O-Streitigkeiten

    Servatius, Wolfgang  

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  • Corporate Litigation || E. D&O-Streitigkeiten

    Servatius   Wolfgang  

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