Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 1 - 16 of 18

  • Association of CD40 SNPs with Moyamoya in a Chinese children population

    Shen, Wenjun   Liao, Yujun   Garcia, Roxanna   Kesavabhotla, Kartik   Xu, Bin   Li, Hao  

    Download Collect
  • Heat transfer characteristics of urea-water spray impingement on hot surfaces

    Liao, Yujun   Dimopoulos Eggenschwiler, Panayotis   Furrer, Roman   Wang, Moyu   Boulouchos, Konstantinos  

    Download Collect
  • METHOD AND APPARATUS OF PROCESSING RETRANSMISSION REQUEST IN DISTRIBUTED COMPUTING

    A method and an apparatus for processing a retransmission request in distributed computing are disclosed. The method includes obtaining a retransmission request to be processed in distributed computing; determining a target copy partition corresponding to the retransmission request based on respective partition response time information of individual copy partitions; sending the retransmission request to the target copy partition. Compared with existing technologies, the present disclosure distinguishes each partition with one another based on a partition response time of the respective copy partition to determine a target copy partition corresponding to a retransmission request, thus selecting a copy with a better response time during retransmission, reducing a response time for the retransmission request and reducing an overall load of an associated cluster.
    Download Collect
  • Fluid Dynamic Comparison of AdBlue Injectors for SCR Applications

    Liao, Yujun   Dimopoulos Eggenschwiler, Panayotis   Spiteri, Alexander   Nocivelli, Lorenzo   Montenegro, Gianluca   Boulouchos, Konstantinos  

    Download Collect
  • Characterization of the urea-water spray impingement in diesel selective catalytic reduction systems

    Liao, Yujun   Dimopoulos Eggenschwiler, Panayotis   Rentsch, Daniel   Curto, Francesco   Boulouchos, Konstantinos  

    Download Collect
  • TASK ALLOCATION METHOD AND SYSTEM

    A task allocation method and system are used for stabilizing a response delay. The method comprises: analyzing at least one query mode according to a target task, and acquiring expected response time of the query mode (102); estimating system overhead information and estimated response time according to the query mode and service description information, and estimating node overhead information processed by each processing node of a system (104); selecting processing nodes according to the node overhead information, and allocating sub-tasks in the target task to the selected processing nodes (106); and determining remaining sub-tasks unallocated in the target task, and scheduling the remaining sub-tasks according to the expected response time, the system overhead information, and the estimated response time (108). Sub-tasks in a target task are processed in batches within expected response time, thereby reducing the overhead of a system on the basis of meeting the expected response time, preventing the response time from being prolonged or stopped due to the problems of the system such as overhead, and stabilizing the response time.
    Download Collect
  • Experimental investigation of the heat transfer characteristics of spray/wall interaction in diesel selective catalytic reduction systems

    Liao, Yujun   Furrer, Roman   Dimopoulos Eggenschwiler, Panayotis   Boulouchos, Konstantinos  

    Download Collect
  • Disappearance of aneurysms associated with moyamoya disease after STA-MCA anastomosis with encephaloduro myosynangiosis

    Ni, Wei   Xu, Feng   Xu, Bin   Liao, Yujun   Gu, Yuxiang   Song, Donglei  

    Moyamoya disease is a rare cerebrovascular disease characterized by steno-occlusive vasculopathy affecting the terminal internal carotid arteries. Although the effect of direct arterial bypass on the prevention of recurrent haemorrhage or ischemic events in patients with hemorrhagic moyamoya disease has been demonstrated, disappearance of aneurysms associated with moyamoya disease has rarely been reported. In this study, we present two patients with aneurysms associated with moyamoya disease. After superficial temporal artery to middle cerebral artery anastomosis combined with encephaloduro myosynangiosis, the aneurysms on the moyamoya vessels disappeared, which was confirmed by follow-up angiography. (C) 2011 Elsevier Ltd. All rights reserved.
    Download Collect
  • Hemodynamic study with duplex ultrasonography on combined (direct/indirect) revascularization in adult moyamoya disease.

    Wang, Yong   Chen, Li   Wang, Yida   Pan, Huiwen   Wang, Yi   Xu, Bin   Liao, Yujun  

    BACKGROUND: To evaluate the hemodynamic changes by duplex ultrasonography in adult moyamoya disease (MMD) patients who underwent combined direct and indirect revascularization surgery.; METHODS: Seventeen adult patients underwent direct and indirect revascularization surgery in our hospital. Hemodynamic parameters, peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index (RI), were determined by color Doppler at the baseline, 2 weeks, and 6 months after bypass.; RESULTS: Both the PSV and EDV of direct bypass were lower at 6 months after surgery compared with those at 2 weeks postoperatively. The EDV of indirect revascularization surgery of the maxillary artery (MA) at 6 months after surgery was higher and the RI of the MA lower compared with the baseline levels. Decreased PSV and EDV in the bypass vessel did not significantly correlate with increased EDV or decreased RI of the MA.; CONCLUSIONS: Duplex ultrasonography is a reliable, noninvasive tool to assess hemodynamic changes and evaluate the therapeutic performance of combined bypass surgery in adult MMD. Copyright =C2=A9 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
    Download Collect
  • A supramolecular assembly mediated by host-guest interactions for improved chemo-photodynamic combination therapy

    Mao, Weipeng   Liao, Yujun   Ma, Da  

    We report a supramolecular nanomedicine (SNM-3) based on a camptothecin-tetraphenyl porphyrin conjugate, camptothecin-polyethylene glycol conjugate, and acyclic cucurbit[n]uril. The supramolecular nanomedicine is tunable by varying the composition of the three components to optimize the nanoscale morphology and therapeutic efficacy. The optimized supramolecular nanomedicine possesses great stability and enhanced intracellular singlet oxygen generation efficiency. Cytotoxicity assay demonstrates that SNM-3 improves the efficacy of chemo-photodynamic combination therapy against three cancer cell lines.
    Download Collect
  • Assessing surgical treatment outcome following superficial temporal artery to middle cerebral artery bypass based on computational haemodynamic analysis.

    Zhu, Fengping   Karunanithi, Kaavya   Qian, Yi   Mao, Ying   Xu, Bin   Gu, Yuxiang   Zhu, Wei   Chen, Liang   Wang, Yong   Pan, Huiwen   Liao, Yujun   Morgan, Michael  

    To estimate haemodynamic modification of Internal Carotid Artery (ICA) after bypass surgery using computational fluid dynamic (CFD) technology and thereby aid in our understanding of the influence of hemodynamic parameters on the outcomes of bypass operations. 18 patients who underwent superficial temporal artery to middle cerebral artery bypass and encephaloduromyosynangiosis (EDMS) surgery were included. Reconstructed three-dimensional vessel geometries from MRA were segmented to create computational domains for CFD simulations. All cases were classified as three groups according to the proportion of the MCA area of distribution supplied by revascularization: A, more than two thirds; B, between two-thirds and one-third; and C, less than one-third of the MCA distribution. Pre-operative and follow-up haemodynamic parameters, especially volume flow rate and pressure drop index (PDI) in ICA were compared. For all cases, PDI and volume flow rate in the surgical-side ICA decreased significantly at follow-up (P<0.05). For the cases of group A, volume flow rate in surgical-side ICA decreased by average 24.2%, whilst for the cases of group B and C, flow rate reduced by 10.5% and 3.7%, respectively. An average PDI for cases in group A was -1.67mmHg, conversely average PDI values of group B and C were -0.53 and 0.82mmHg, respectively. The remodelling of ICA after bypass was associated with reduction in the volume flow rate and pressure drop. Good correlation with angiographic grading suggested that CFD might play a critical role as a quantitative haemodynamic technique for predicting treatment outcome during the follow-up of MMD patients. Copyright =C2=A9 2015 Elsevier Ltd. All rights reserved.
    Download Collect
  • Cross-Linked Pillar[6]arene Nanosponges Fabricated by the Use of a Supra-Amphiphilic Template:Cargo Encapsulation and Overcoming Multidrug Resistance

    Liu, Yamin   Liao, Yujun   Li, Pintao   Li, Zhan-Ting   Ma, Da  

    We report a general fabrication method for water-soluble pillar[n]arene nanosponges (NS) by the use of a supra-amphiphilic template. For the first time, a supra-amphiphilic template is used to conveniently control the size of host molecule-based NS. The intrinsic cavity of water-soluble pillar[6]arene could stably encapsulate dyes (acridine orange and indocyanine green) and antitumor drugs (doxorubicin hydrochloride and mitoxantrone) by host-guest interaction. NS could deliver antitumor drugs to cancer cells. Multidrug resistance (MDR) of cancer cells (MCF-7/ADR) is overcome by the use of NS with a ninefold reduction in the IC50 value compared to that of the free drug (3.4 mu M vs 34.4 mu M). Mechanistic studies show that stable encapsulation of the antitumor drug is the reason to overcome MDR.
    Download Collect
  • Clinical approach of using Onyx via transarterial access in treating tentorial dural arteriovenous fistula.

    Liu, Chuanghong   Xu, Bin   Song, Donglei   Leng, Bing   Mao, Ying   Gu, Yuxiang   Liao, Yujun  

    OBJECTIVE: In this study, based on clinical presentation and angiographic findings, we try to investigate the possibility to do transarterial embolization using Onyx to treat tentorial dural arteriovenous fistula (TDAVF). Particular attention will be given to the relationship between vascular anatomic characteristics and clinical management.; METHODS: We retrospectively reviewed the clinical and radiologic data of 26 patients with TDAVFs, who were treated via transarterial approach using Onyx (including three cases treating with balloon assisting) at our department from January 2005 to April 2010.; RESULTS: The total obliterated rate was 85.7, 53.8, and 66.7% in the tentorial marginal, lateral, and medial subtype, respectively. Symptoms were improved significantly in the patients whose fistulas were totally and sub-totally obliterated. The mean follow-up duration was 2.9 years. After operation, patients' symptom was dramatically improved indicated by the decrease of individual modified Rankin scale (MRS). Only one patient suffered from temporary paralysis of cranial nerve (CN) III. All 26 patients were clinically stable and without any relapsed, increased, or new symptoms. All patients had resumed their normal activities until the latest follow-up.; CONCLUSION: Treating the TDAVF via transarterial approach using Onyx maybe a feasible clinical practice. The fistula obliterated rate is highly related to the anatomic characteristic, and high complete obliterated rate can be achieved. Our preliminary results showed that Onyx injection with 'balloon assisting' technique can be helpful in some of the cases.=20
    Download Collect
  • Association of CD40 SNPs with Moyamoya in a Chinese children population

    Shen, Wenjun   Liao, Yujun   Garcia, Roxanna   Kesavabhotla, Kartik   Xu, Bin   Li, Hao  

    Background: The etiology of Moyamoya disease (MMD) remains unknown to a large extent. Immune and inflammation dysfunction may play a role in the pathogenesis of this rare disease. Coexisting Kawasaki disease (KD) with MMD were reported and both diseases have a feature of vasculopathy, raising the hypothesis that there may be some common pathologic factors. We investigated single nucleotide polymorphisms (SNPs) previously identified in KD and performed a genetic analysis among Chinese pediatric patients with MMD. Results: We analyzed patients' DNA for the SNPs in B lymphoid tyrosine kinase, CD40, and coatomer protein complex beta-2 subunit, which had been associated with KD by literatures. Genotyping was performed by sequencing the genetic regions containing the SNPs with customized primers. A total of 5 genotype polymorphisms were examined among 48 pediatric MMD cases and 50 healthy controls. The mean age of MMD children was 6.72 +/- 3.63 years old, while 7.31 +/- 3.79 in controls. We found two SNPs of CD40 were associated with MMD. Polymorphisms rs4813003 major allele CC and rs1535045 minor allele TT were significantly higher in MMD cases. The other SNPs showed no statistical difference between MMD cases and controls. Conclusions: Our findings provide evidence that there may be a relationship between MMD and auto-immune dysfunction. We hypothesize that these genetic features may lead to the pathogenesis within the vascular wall. Further study regarding whether CD40 can function as the personalized target of MMD should be investigated in future.
    Download Collect
  • Enlarged Encephalo-Duro-Myo-Synangiosis Treatment for Moyamoya Disease in Young Children

    Xu, Bin   Li, Hao   Gao, Xiaofeng   Liao, Yujun   Shi, Wei   Zhao, Rui   Zhang, Yi  

    OBJECTIVE: To retrospectively evaluate the midterm therapeutic effect of enlarged encephalo-duro-myo-synangiosis (EDMS) for moyamoya disease (MMD) in young children.METHODS: Seventy-seven children diagnosed with MMD by digital subtraction angiography (DSA) or magnetic resonance angiography (MRA) were treated between January 2011 and December 2014 in our center. Their clinical features, imaging, and operative reports were analyzed.RESULTS: Four patients presented with intracerebral hemorrhage, whereas 73 presented with ischemic symptoms. Revascularization procedures were performed unilaterally on 11 left hemispheres and 9 right hemispheres, and 57 had bilateral surgeries. The average length of surgery was 143 +/- 24 minutes, with 28 +/- 9 mL of blood loss. The mean period of follow-up was 28.43 +/- 15.31 months. Cerebral blood flow increased 3 months after the operations in the previously affected regions. Collateralization from the deep temporal artery, superficial temporal artery, and the middle meningeal artery was found by DSA or MRA. In cases where single-photon emission computed tomography was obtained, it demonstrated better perfusion postoperatively. The ischemic symptoms were relieved in 118 (88.06%) hemispheres, and remained stable in 5 (3.73%) hemispheres. There were 12 radiographic cerebral infarctions (8.96%) within 1 month postoperatively.CONCLUSIONS: Enlarged EDMS is safe and effective for MMD in young children. Extensive and multilayered revascularization could significantly preserve neurologic function. The long-term effect on posterior circulation disease development needs further investigation.
    Download Collect
  • Experimental investigation of the heat transfer characteristics of spray/wall interaction in diesel selective catalytic reduction systems

    Liao, Yujun   Furrer, Roman   Eggenschwiler, Panayotis Dimopoulos   Boulouchos, Konstantinos  

    This study presents an experimental investigation of the heat transfer characteristics of the spray/wall interaction in diesel selective catalytic reduction (SCR) systems. The work was performed with a commercial 3-Hole pressure-driven injector dosing into a flow channel under typical diesel exhaust flow conditions. Infrared thermography captured the surface temperature of the wall around the impingement area with high temporal and spatial resolution. The resulting temperatures have been used for assessing the heat extracted from the wall. Phase Doppler Anemometry (PDA) was applied to measure the droplet sizes and velocities prior to the wall impingement, providing information on the kinetic properties of the impinging droplets. Based on these, the influence of the gas flow conditions on the heat transfer characteristics is deduced. The spray impingement leads to a substantial and rapid temperature drop on the wall, resulting in a maximum heat flux of several MW/m(2) during the injection duration. The spray cooling effect decreases with increasing exhaust gas flow rate due to the increased entrainment of spray droplets in the flow prior to impingement. Increase in gas flow temperature affects the heat transfer by increasing the wall temperature. At lower wall temperatures, the principal spray/wall interaction regime is deposition. With increasing wall temperature, there is a shift to rebound and thermal breakup. The shorter contact times in the rebound and thermal breakup regimes result in decreased spray/wall heat transfer. (C) 2016 Elsevier Ltd. All rights reserved.
    Download Collect
1 2

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback