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Now showing items 1 - 16 of 91

  • Lakshmi\"s Legacy: The Testimonies of Indian Women in 19th Century Mauritiusby Marina Carter

    Review by: Richard B. Allen  

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  • Hardware co simulation of LTE physical layer for mobile network applications

    Venkataramanan, V.   Lakshmi, S.  

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  • Structural Analysis and Liquid Crystalline Property of 4, 4′-Methoxy Bis-hydrazone

    Lakshmi, S.   Sridhar, M. A.   Shashidhara Prasad, J.   Indira, J.   Karat, Prakash P.   Veerendra, B.   Shivarama Holla, B.  

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  • Synthesis and Structural Analysis of Tetraethylammonium Trichloro-cadmate


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  • Synthesis and Structural Analysis of Tetrathioureacopper(I) Chloride


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  • Effect of electron-phonon coupling on the conductance of a one-dimensional molecular wire

    Lakshmi, S.   Pati, Swapan K.  

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  • In situ preparation of TiB2 reinforced Al based composites

    Lakshmi, S.   Lu, L.   Gupta, M.  

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  • Molecular Electronics: Effect of External Electric Field

    Lakshmi, S.   Dutta, Sudipta   Pati, Swapan K.  

    The effect of electric field, applied on systems in the nanoscale regime has attracted a lot of research in recent times. We highlight some of the recent results in the field of single molecule electronics and then move on to focus on some of our own results in this area. We have first shown how important it is to obtain the spatial profile of the external bias potential across the system, and how this would change in the presence of electron-electron interactions. We have also studied different kinds of insulators in the presence of the spatially varying external bias and have explicitly shown that a two sublattice structure, caused either by a lattice distortion, or by the presence of substituents with strong dipolar nature, can result in negative differential resistance (NDR) in the transport characteristics. We also find this to be true in case of correlated insulators. Additionally, we have shown clear NDR behavior in a correlated double quantum dot by tuning the electron-electron interaction strength in the system.
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  • Editorial [Hot Topic: Nanostructure for Therapeutics Applications (Guest Editor: Cato T. Laurencin and Lakshmi S. Nair)]

    Laurencin, Cato   Nair, Lakshmi  

    It is our honor and privilege to serve as the Guest Editors of the Special Edition on “Nanostructures for Therapeutic Applications” for the journal “Current Bioactive Compounds”. The past decade has witnessed an unprecedented growth in the area of nanotechnology. This in turn has provided valuable tools to understand the biological systems and processes at a much closer level than was previously possible. The combination of nanotechnology and biology has also led to the development of a new generation of therapeutic devices with high therapeutic efficacy. This is mainly due to their ability to precisely interact with the sub-microscopic structures of living cells. The aim of the special edition is to provide a state-of-the-art, comprehensive account of the recent advances towards developing nanostructures for four different therapeutic applications. The article by Peach et al. discusses the recent developments in the nanotechnological approaches for the treatment of cancer. The authors provide an overview of the passive, active and external tumor targeting strategies using nanoparticle (NP) delivery systems. The article by Freeman et al., overviews the recent developments in the nanofabrication processes for promoting musculoskeletal tissue regeneration. The article discusses the various nanostructures currently been developed to modulate musculoskeletal cell functions to promote regeneration. The article by Wang et al., highlights the various unique nanostructures capable of by-passing the blood-brain barrier, a feat difficult to achieve using conventional therapeutic strategies. Finally, the article by Neal et al., presents an overview of the applications of nanomedicine to promote cardiovascular tissue regeneration. The guest editors would like to express their sincere gratitude to the editorial board of the Current Bioactive Compounds for their support. We would also like to appreciate all the authors for their valuable contributions in making this special edition a success.
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  • c-erbB-2 Oncoprotein and Epidermal Growth Factor Receptor in Cervical Lesions

    Lakshmi, S.   Nair, Balaraman   Jayaprakash, P.G.   Rajalekshmy, T.N.   Nair, Krishnan   Pillai, Radhakrishna  

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  • Study on TiO2-mediated photocatalytic degradation of methylene blue

    Lakshmi, S.   Renganathan, R.   Fujita, S.  

    The degradation (oxidation) of methylene blue assisted by TiO2 photocatalysis (with an irradiation wavelength of 365 nm) was investigated in aqueous suspension. The rate constants for this heterogeneous photocatalysis were evaluated as a function of the concentration of the dye, the amount of TiO2 and the pH. The reaction is found to conform to a Langmuir adsorption isotherm and the rate vs. pH profile exhibits a linear increase with pH in acidic solutions with a maximum at around pH 6.9.
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  • Shape transition and tilted axis rotation in

    Lakshmi, S.   Jain, H. C.   Joshi, P. K.   Amita,    Agarwal, P.   Jain, A. K.   Malik, S. S.  

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  • -conjugated chain: Role of electron correlations

    Lakshmi, S.   Datta, Ayan   Pati, Swapan K.  

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  • Magnetic rotation and shape mixing in

    Lakshmi, S.   Jain, H. C.   Joshi, P. K.   Jain, A. K.   Malik, S. S.  

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  • Biodegradable polyphosphazenes for drug delivery applications

    Lakshmi, S.   Katti, D.S.   Laurencin, C.T.  

    Biodegradable polymers such as poly(α-hydroxy acids), poly(anhydrides), poly(ortho esters), poly(amino acids) and polyphosphazenes have raised considerable interest as short-term medical implants due to their transient nature. Among these, polyphosphazenes are a relatively new class of polymers, quite distinct from all the biodegradable polymers synthesized so far, due to their synthetic flexibility and versatile adaptability for applications. These are high molecular weight, essentially linear polymers with an inorganic backbone of alternating phosphorous and nitrogen atoms bearing two side groups attached to each phosphorous atom. Controlled tuning of physico-chemical properties, including biodegradability, can be achieved in this class of polymers via macromolecular substitutions. Biodegradable polyphosphazenes, due to their hydrolytic instability, nontoxic degradation products, ease of fabrication and matrix permeability, are an excellent platform for controlled drug delivery applications. This review discusses the mode of degradation and drug delivery applications of biodegradable polyphosphazenes.
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  • Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride)

    Lakshmi, S.   Jayakrishnan, A.  

    Plasticized poly(vinyl chloride) (PVC) was surface modified by nucleophilic substitution of the chlorine atoms of PVC by thiosulphate in aqueous media in the presence of a phase-transfer catalyst. The properties of the modified surface were evaluated by contact angle measurements, attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. Migration of the plasticizer di-(2-ethylhexyl) phthalate from control as well as modified PVC was examined in hexane, in cottonseed oil and in poly(ethylene glycol)-400 (PEG-400). While the modified PVC was found to be highly migration resistant in hexane, cottonseed oil and PEG-400 extracted the plasticizer. The modified PVC was found to cause haemolysis and was cytotoxic. A possible explanation for the difference in performance of the modified material in different extraction media and its toxicity is presented from a mechanistic view of the substitution process.
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