Answering a problem posed by John Michael Rassias, we study the functional inequality f (x + y + xy) <= f (x) + f (y) + f (xy), with real unknown mapping f.
This work analyses the evolution of the scientific visibility of the neurophysiologist Jose Manuel Rodriguez Delgado. It examines the longitudinal evolution from 1955 to 2013 of an article (Delgado, Roberts, & Miller, 1954) studying the neurological basis of learning and motivation and compares it with a coetaneous article (Olds & Milner, 1954) with a similar subject and methodology. Both studies have been essential in Psychology. This work analyses the number of times each article has been cited between 1955-1984 and 1985-2013. The results show that the visibility of James Olds and Peter Milner's article (expressed in number of citations between 1955-1984 and 1985-2013) has longitudinally increased (p < .001), whereas the number of citations received by Jose Manuel Rodriguez Delgado et al.'s article has significantly reduced (p < .001). The results are discussed and the low visibility of Delgado's article is explained through historical and social factors, including the growing concern about compliance with bioethical and research guidelines and the controversial media projection of the Spanish scientist, not by the intrinsic value or the scientific repercussion of the compared articles.
Abbott, Michael C.
Murugan, Jeff
Penati, Silvia
Pittelli, Antonio
Sorokin, Dmitri
Sundin, Per
Tarrant, Justine
Wolf, Martin
Wulff, Linus
We verify the self-duality of Green-Schwarz supercoset sigma models on AdS(d) x S-d backgrounds (d =3D 2, 3, 5) under combined bosonic and fermionic T-dualities without gauge fixing kappa symmetry. We also prove this property for superstrings on AdS(d) x S-d x S-d (d =3D 2, 3) described by supercoset sigma models with the isometries governed by the exceptional Lie supergroups D(2, 1; alpha) (d =3D 2) and D(2, 1; alpha) x D(2, 1; alpha) (d =3D 3), which requires an additional T-dualisation along one of the spheres. Then, by taking into account the contribution of non-supercoset fermionic modes (up to the second order), we provide evidence for the T-self-duality of the complete type IIA and IIB Green-Schwarz superstring theory on AdS(d) x S-d x T10-2d (d =3D 2, 3) backgrounds with Ramond-Ramond fluxes. Finally, applying the Buscher-like rules to T-dualising supergravity fields, we prove the T-self-duality of the whole class of the AdS(d) x S-d x M10-2d superbackgrounds with Ramond-Ramond fluxes in the context of supergravity.
Ways on energy enhancement for single frequency oscillator are reported in this paper.By quantitative analysis on gain and loss coefficients for each cavity mode with inserted etalons,a 37 mJ,100 Hz high energy single-frequency Nd∶YAG oscillator is obtained.The pulse energy is promoted by enhancement of nearly 7 times for a single frequency oscillator reported.The result proves that this method does help for energy enhancement.It has attractive potential for high energy single frequency oscillator design,especially on condition of intensive side pumped or long cavity laser,where strong competitors exist and are hard to be suppressed.
V(D)J recombination is the process by which the diversity of antigen receptor genes is generated and is also indispensable for lymphocyte development. This recombination event occurs in a cell lineage- and stage-specific manner, and is carefully controlled by chromatin structure and ordered histone modifications. The recombinationally active V(D)J loci areassociated with hypermethylation at lysine4 of histone H3 and hyperacetylation of histones H3/H4. The recombination activating gene 1 (RAG1) and RAG2 complex initiates recombination by introducing double-strand DNA breaks at recombination signal sequences (RSS) adjacent to each coding sequence. To be recognized by the RAG complex, RSS sites must bewithin an open chromatin context. In addition, the RAG complex specifically recognizes hypermethylated H3K4 through its plant homeodomain (PHD) finger in the RAG2 C terminus, whichstimulates RAGcatalytic activity via that interaction. In this review, we describe how histone methylation controls V(D)J recombination and discuss its potential role in lymphoid malignancy by mistargeting the RAG complex. =20
Charlotte Proudhon
Bingtao Hao
Ramya Raviram
Julie Chaumeil
Jane A. Skok
Given their essential role in adaptive immunity, antigen receptor loci have been the focus of analysis for many years and are among a handful of the most well studied genes in the genome. Their investigation led initially to a detailed knowledge of linear structure and characterization of regulatory elements that confer control of their rearrangement and expression. However, advances in DNA FISH and imaging combined with new molecular approaches that interrogate chromosome conformation have led to a growing appreciation that linear structure is only one aspect of gene regulation and in more recent years the focus has switched to analyzing the impact of locus conformation and nuclear organization on control of recombination. Despite decades of work and intense effort from numerous labs we are still left with an incomplete picture of how antigen receptor loci are regulated. This chapter summarizes our advances to date and points to areas that need further investigation.