Gatti, G.
Simsek, S.
Kurne, A.
Zurrida, S.
Naninato, P.
Veronesi, P.
Frasson, A.
Millen, E.
Rososchansky, J.
Luini, A.
Paraneoplastic syndromes are the rarest neurological complications in patients with cancer. The neurological paraneoplastic syndromes that are mainly associated with breast cancer are subacute cerebellar degeneration, paraneoplastic retinopathy, opsoclonus-myoclonus syndrome, lower motor neuron diseases and Stiffman syndrome. The aim of this paper is to briefly outline these paraneoplastic neurological syndromes and consider their relation to breast carcinoma.
Michelucci, R.
Cipolla, G.
Passarelli, D.
Gatti, G.
Ochan, M.
Heinig, R.
Tassinari, C. A.
Perucca, E.
Purpose: To assess whether phenytoin affects the pharmacokinetics of the dihydropyridine calcium antagonist nisoldipine. Methods: Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively). Blood samples were collected for up to 48 h for estimation of plasma nisoldipine levels by capillary gas chromatography. Results: Mean plasma nisoldipine concentrations were much lower in the patients. Geometric means for areas under the concentration-time curve (AUC-0-tn) normalized to a 20-mg dose were 1.6 mu-g/L/h (95% confidence intervals, 0.6-3.8 mu-g/ L/h) in the patients compared with 15.2 (10.7-21.6) mu-g/L/h in control subjects (p lt 0.002). Conclusions: These results suggest that phenytoin increases the first-pass metabolism of nisoldipine to a clinically important extent. In view of the magnitude and variability of interaction, use of nisoldipine in patients receiving chronic phenytoin therapy is contraindicated.
The interpretation of experimental data from nonlinear structures is challenging, primarily because of dependency on types and levels of excitation, and coupling issues with test equipment. In this paper, the use of the dynamic stiffness method, which is commonly used in the analysis of linear systems, is used to interpret the data from a vibration test of a controllable compressed beam structure coupled to a test shaker. For a single mode of the system, this method facilitates the separation of mass, stiffness and damping effects, including nonlinear stiffness effects. It also allows the separation of the dynamics of the shaker from the structure under test. The approach needs to be used with care, and is only suitable if the nonlinear system has a response that is predominantly at the excitation frequency. For the structure under test, the raw experimental data revealed little about the underlying causes of the dynamic behaviour. However, the dynamic stiffness approach allowed the effects due to the nonlinear stiffness to be easily determined. (C) 2018 Elsevier Ltd. All rights reserved.
Grittani, G. M.
Anania, M. P.
Gatti, G.
Giulietti, D.
Kando, M.
Krus, M.
Labate, L.
Levato, T.
Oishi, Y.
Rossi, F.
Gizzi, L. A.
In this paper we discuss the spectra of the electrons produced in the laser-plasma acceleration experiment at FLAME. Here a <30 fs laser pulse is focused via an f/10 parabola in a focal spot of 10 mu m diameter into a 1.2 mm by 10 mm rectangular Helium gas-jets at a backing pressure ranging from 5 to 15 bar. The intensity achieved exceeds 10(19) Wcm(-2). In our experiment the laser is set to propagate in the gas-jet along the longitudinal axis to use the 10 mm gas-jet length and to evaluate the role of density gradients. The propagation of the laser pulse in the gas is monitored by means of a Thomson scattering optical imaging. Accelerated electrons are set to propagate for 47,5 cm before being detected by a scintillating screen to evaluate bunch divergence and pointing. Alternatively, electrons are set to propagate in the field of a magnetic dipole before reaching the scintillating screen in order to evaluate their energy spectrum. Our experimental data show highly collimated bunches (<1 mrad) with a relatively stable pointing direction (<10 mrad). Typical bunch electron energy ranges between 50 and 200 MeV with occasional exceptional events of higher energy up to 1GeV.
The authors present a (2times5) matrix amplifier with a DC power consumption as low as 200 mW with 13 dBm of RF output power (@1 dB compression point) achieving 7 dB small-signal gain (residual ripple 0.3 dB) and input and output return losses always better than -14 dB. Designed using the LN05 monolithic process of Thomson Composants Microondes (TCM), the amplifier employs ten MESFETs of 160 mum gate width and submicron (0.5 mum) gate length, for a total chip area of 2.5times3.5 mm 2. Broadband performance and very low power consumption make this amplifier very well suited for end-volume realisation of monolithic multiple-stage front-ends in integrated high bit-rate optical receivers
Petrarca, M.
Henin, S.
Berti, N.
Matthews, M.
Chagas, J.
Kasparian, J.
Wolf, J. -P.
Gatti, G.
Di Pirro, G.
Anania, M. -P.
Ferrario, M.
Ghigo, A.
We characterized the white-light supercontinuum emission by a sub-petawatt laser system in the atmosphere via light detection and ranging measurements. As much as 1 J of supercontinuum is generated in the atmosphere, corresponding to a conversion efficiency of 30 %. This generation occurs at altitudes below 100 m. The high initial beam intensity results in the saturation of the number of self-guided filaments. Therefore, the "photon bath" surrounding the filaments strongly contributes to the white-light generation. These finding is well reproduced by numerical simulations based on the experimental parameters.
Ferrario, M.
Alesini, D.
Bacci, A.
Bellaveglia, M.
Boni, R.
Boscolo, M.
Calvani, P.
Castellano, M.
Chiadroni, E.
Cianchi, A.
Cultrera, L.
Di Pirro, G.
Ficcadenti, L.
Filippetto, D.
Gallo, A.
Gatti, G.
Giannessi, L.
Labat, M.
Lupi, S.
Marchetti, B.
Marrelli, C.
Migliorati, M.
Mostacci, A.
Nicoletti, D.
Pace, E.
Palumbo, L.
Petrillo, V.
Quattromini, M.
Ronsivalle, C.
Rossi, A. R.
Rosenzweig, J.
Serafini, L.
Serluca, M.
Spataro, B.
Tomizawa, H.
Vaccarezza, C.
Vicario, C.
A new technique, named "laser comb", was tested during the last SPARC run. It is able to produce electron pulse trains with a charge of some hundreds pC, a repetition rate of some terahertz, and a sub-picosecond length. This technique is based on the velocity bunching configuration of the SPARC injector. It can be useful to drive pump and probe free-electron laser experiments, to generate coherent excitation of plasma waves in plasma accelerators, and to produce narrow band terahertz radiation. In this paper, we describe the experimental results achieved so far and provide a comparison with simulations. (C) 2010 Elsevier B.V. All rights reserved.
Chiadroni, E.
Bacci, A.
Bellaveglia, M.
Boscolo, M.
Castellano, M.
Cultrera, L.
Di Pirro, G.
Ferrario, M.
Ficcadenti, L.
Filippetto, D.
Gatti, G.
Pace, E.
Rossi, A. R.
Vaccarezza, C.
Catani, L.
Cianchi, A.
Marchetti, B.
Mostacci, A.
Palumbo, L.
Ronsivalle, C.
Di Gaspare, A.
Ortolani, M.
Perucchi, A.
Calvani, P.
Limaj, O.
Nicoletti, D.
Lupi, S.
Ultra-short electron beams, produced through the velocity bunching compression technique, are used to drive the SPARC linear accelerator based source, which relies on the emission of coherent transition radiation in the terahertz range. This paper reports on the main features of this radiation, as terahertz source, with spectral coverage up to 5 THz and pulse duration down to 200 fs, with an energy per pulse of the order of several micro-joule, and as electron beam longitudinal diagnostics. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4794014]
Gatti, G.
Costenaro, D.
Vittoni, C.
Paul, G.
Crocella, V.
Mangano, E.
Brandani, S.
Bordiga, S.
Cossi, M.
Marchese, L.
Bisio, C.
Hybrid organic-inorganic SBA-15 silicas functionalized with increasing amounts of amino groups were studied in this work aiming to evaluate the effects of their physico-chemical properties on CO2 capture ability. Three different amino-silane species were used: 3-aminopropyltriethoxysilane (APTS), 3-(2-aminoethyl)-aminopropyltrimethoxysilane (EAPTS) and 3-[2-(2-aminoethyl)aminoethyl] aminopropyltrimethoxysilane (PAPTS). More specifically, samples were prepared by using two methods, following a post-synthesis grafting procedure and a one-pot preparation method. Experimental and computational techniques were used to study the structural and textural properties of the obtained samples and their surface species in relation to the adopted preparation method. For the most reactive samples, additional hints on the interactions of organosilane species with the silica surface were obtained by a combination of IR and SS-NMR spectroscopy, with particular emphasis on the effects of the silane chain length on the mobility of the organic species. Advanced complementary solid-state NMR techniques provided deeper information on the interactions of organosilane species with the silica surface. Finally, the amount of CO2 adsorbed was estimated by comparing the classical microcalorimetric analysis method with a new type of screening test, the Zero Length Column analysis, which is able to evaluate small amounts of samples in a very short time and the adsorption properties of the adsorbents. The reactivity of the amino-modified silica samples is deeply influenced by both the preparation route and by the type of organosilane used for the functionalization of the materials. In particular, samples prepared by the post-synthesis grafting procedure and containing higher amount of amino groups in the chain are more reactive, following the order PAPTS > EAPTS > APTS.
Chiadroni, E.
Bellaveglia, M.
Calvani, P.
Castellano, M.
Catani, L.
Cianchi, A.
Di Pirro, G.
Ferrario, M.
Gatti, G.
Limaj, O.
Lupi, S.
Marchetti, B.
Mostacci, A.
Pace, E.
Palumbo, L.
Ronsivalle, C.
Pompili, R.
Vaccarezza, C.
The linac driven coherent THz radiation source at the SPARC-LAB test facility is able to deliver broadband THz pulses with femtosecond shaping. In addition, high peak power, narrow spectral bandwidth THz radiation can be also generated, taking advantage of advanced electron beam manipulation techniques, able to generate an adjustable train of electron bunches with a sub-picosecond length and with sub-picosecond spacing. The paper reports on the manipulation, characterization, and transport of the electron beam in the bending line transporting the beam down to the THz station, where different coherent transition radiation spectra have been measured and studied with the aim to optimize the THz radiation performances. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4790429]
Chiadroni, E.
Bacci, A.
Bellaveglia, M.
Calvani, P.
Castellano, M.
Cianchi, A.
Di Pirro, G.
Ferrario, M.
Gatti, G.
Limaj, O.
Lupi, S.
Marchetti, B.
Mostacci, A.
Nicoletti, D.
Nucara, A.
Pace, E.
Ronsivalle, C.
Rossi, A. R.
Vaccarezza, C.
The linac driven coherent THz radiation source at the SPARC facility is able to deliver broadband THz pulses with femtosecond shaping. In addition, high peak power, narrow-band THz radiation can be also generated, taking advantage from advanced electron beam manipulation techniques, able to generate a train of short electron bunches with THz repetition rate.
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