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Now showing items 49 - 64 of 782

  • Tunable controlled release of bioactive SDF-1α via specific protein interactions within fibrin/nanoparticle composites

    Dutta, D.   Fauer, C.   Mulleneux, H. L.   Stabenfeldt, S. E.  

    The chemokine, stromal cell-derived factor 1α (SDF-1α), is a key regulator of the endogenous neural progenitor/stem cell-mediated regenerative response after neural injury. Increased and sustained bioavailability of SDF-1α in the peri-injury region is hypothesized to modulate this endogenous repair response. Here, we describe poly(lactic-co-glycolic) acid (PLGA) nanoparticles capable of releasing bioactive SDF-1α in a sustained manner over 60 days after a burst of 23%. Moreover, we report a biphasic cellular response to SDF-1α concentrations thus the large initial burst release in an in vivo setting may result in supratherapeutic concentrations of SDF-1α. Specific protein–protein interactions between SDF-1α and fibrin (as well as its monomer, fibrinogen) were exploited to control the magnitude of the burst release. Nanoparticles embedded in fibrin significantly reduced the amount of SDF-1α released after 72 h as a function of fibrin density. Therefore, the nanoparticle/fibrin composites represented a means to independently tune the magnitude of the burst phase release from the nanoparticles while perserving a bioactive depot of SDF-1α for release over 60 days.
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  • Structural aspects of synthetic zeolite: A comparative assay through positron annihilation and gas adsorption methods

    Dutta, D.   Chatterjee, S.   Ganguly, B. N.   Pillai, K. T.  

    Structural arrangement in alumino-silicate compounds (synthetic zeolite species), which encompasses large cavities and channels, have been discussed on the basis of their molecular organization and is further illustrated with the help of micrographs as perceived through transmission electron microscopic studies. The crystallinity aspects and structural defects were investigated through line broadening in x-ray diffraction and the grain sizes through the Debye-Scherrer method. Further, assays of the void size (micro- as well as mesopores) have been performed through positronium annihilation lifetime spectroscopy (PALS) and Brunauer-Emmett-Teller adsorption-desorption isotherm and compared. Despite of some of the limitations of the latter, the final results are in close agreement. The utility of PALS as a microprobe is illustrated through our models. Finally, it has been justified that PALS not only probes the subnanometer micropore sizes efficiently but it also senses the mesopores
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  • Motion artifact reduction in ultrasound based thermal strain imaging of atherosclerotic plaques using time-series analysis

    Dutta, D.   Mahmoud, A. M.   Leers, S. A.   Kang Kim,  

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  • Serum fetuin-A concentration predicts glycaemic outcomes in people with prediabetes: a prospective study from eastern India

    Dutta, D.   Mondal, S. A.   Kumar, M.   Hasanoor Reza, A. H.   Biswas, D.   Singh, P.   Chakrabarti, S.   Mukhopadhyay, S.  

    Aim To evaluate the role of fetuin-A levels in predicting glycaemic outcomes (progression to diabetes or reversion to normoglycaemia) in people with prediabetes. Methods A total of 2119 people were screened, of whom 144 people with prediabetes, 50 people with normoglycaemia and 66 people with newly diagnosed diabetes underwent estimation of fasting insulin, fetuin-A, interleukin-6, interleukin-1 beta, tumour necrosis factor-alpha, lipid and 25-hydroxyvitamin-D levels and assessment of non-alcoholic fatty liver disease using ultrasonography and the fatty liver index. People with prediabetes were followed and analysed according to glycaemic outcome and quartile of fetuin-A level. Results Fetuin-A, interleukin-1 beta, interleukin-6, tumour necrosis factor-alpha and triglyceride levels and presence of non-alcoholic fatty liver disease increased across the glycaemic spectrum and were highest in people with diabetes. A total of 32 people with prediabetes reverted to normoglycaemia, 23 progressed to diabetes and 65 remained with prediabetes over a mean +/- SD follow-up of 32.12 +/- 8.4 months. People progressing to diabetes had higher baseline glycaemia rates, fetuin-A levels, interleukin-1 beta levels, fatty liver index scores and prevalence of non-alcoholic fatty liver disease and lower 25-hydroxyvitamin-D levels. People with prediabetes in the highest fetuin-A quartile had the highest risk of progression to diabetes (relative risk 2.68, 95% CI 0.95-7.55; P = 0.06) and the lowest rate of reversion to normoglycaemia (relative risk 0.27, 95% CI 0.08-0.85; P = 0.03). Fetuin-A levels correlated with interleukin-1 beta levels (r = 0.420; P < 0.001), interleukin-6 levels (r = 0.231; P = 0.022) and fatty liver index scores (r = 0.319; P < 0.001). Cox regression showed that higher fetuin-A levels and higher BMI and lower 25-hydroxyvitamin-D levels were predictive of lower rates of reversion to normoglycaemia. Age, triglyceride levels, and interleukin-6 and interleukin-1 beta levels were predictive of progression to diabetes. Conclusions Increased fetuin-A level has an adverse impact on glycaemic outcomes in prediabetes. This study highlights the importance of fetuin-A as a predictor of glycaemic outcomes in prediabetes.
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  • Fatigue Tests and Design of Offshore Tubular Joints

    Dutta, D.   Mang, F.  

    The AWS-X “hotspot stress-load cycle” curve used at present for designing tubular joints is based mainly on the fillet-welded plate test data and some more data from small-scale tests on tubular joints, which were available in the early 1970s. A review of further tests carried out in the recent years, including those by the authors, leads to the conclusion that the influence of the diameter and thickness of the tubes plays a significant role in the joint fatigue behavior. Hence, they must be taken into consideration while designing tubular joints accurately and more economically. A modified design method is proposed here with design curves for four diameter values. Further, the results of fatigue tests on K-type joints investigating the effect of stress ratio R and of post-weld heat treatment on the joint fatigue strength are described in this paper.
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  • Newly developed chromium-doped fiber as a saturable absorber at 1.55- and 2.0-µm regions for Q-switching pulses generation

    Dutta, D.   Paul, M.C.   Dhar, A.   Das, S.   Rusdi, M.F.M.   Latiff, A.A.   Ahmad, H.   Harun, S.W.  

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  • Influence of graphene growth temperature by chemical vapour deposition on the hydrogen response of palladium–graphene junction

    Dutta, D.   Das, J.   Hazra, S. K.   Sarkar, C. K.   Basu, S.  

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  • Structures with Hollow Sections (D. Dutta)

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  • 192 Disassembling parallel assemblies: D. Dutta, A.C. Woo, pp 125–129

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  • Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex

    Dutta, D.   Hickey, K.   Salifu, M.   Fauer, C.   Willingham, C.   Stabenfeldt, S. E.  

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  • Temperature- and Hydrogen-Gas-Dependent Reversible Inversion ofn-/p-Type Conductivity in CVD-Grown Multilayer Graphene (MLG) Film

    Dutta, D.   Hazra, S. K.   Das, J.   Sarkar, C. K.   Basu, S.  

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  • Computer-aided process planning for parallel machines: J. Levin, D. Dutta, pp. 79–92

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  • 886186 Rock mass classification model for caving roofs : Ghose, A K; Dutta, D Int J Min Geol EngngV5, N3, Oct 1987, P257–271

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  • Freezing of Nanodroplets: Phase Transition of Organic Liquids Confined in Nanopores Studied by Positron Annihilation Spectroscopy

    Dutta, D.   Sharma, S.K.   Maheshwari, P.   Sudarshan, K.   Pujari, P.K.  

    Behavior of solids and liquids confined in nano domain has great relevance in fundamental research as well as applications in nanotribology, nanofabrication, membrane separation, interfacial adhesion and lubrication. In this work, we have studied phase transition behavior of different organic liquids confined in nanopores of ZSM-5 zeolite and silica using temperature dependent positron annihilation Doppler broadening and lifetime spectroscopy. It is observed that the freezing and melting properties of liquids confined in nanopores are different from their bulk behavior. The liquid molecules (isopropanol) that feel more attractive interaction with the pore wall show an increase in freezing temperature. Similarly, a liquid like benzene which is weakly attractive with pore wall as compared to its solid phase show a decrease in its freezing point under confinement. The confining pore diameters are in the range of 10-60 Aring. It was observed that the shift in phase transition temperature does not follow classical Gibbs-Thomson relation.
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  • Enhancing the Capability of a Simple, Computationally Efficient, Conceptual Flood Inundation Model in Hydrologically Complex Terrain

    Teng, J.   Vaze, J.   Kim, S.   Dutta, D.   Jakeman, A. J.   Croke, B. F. W.  

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  • Efficacy of norfloxacin and doxycycline for treatment of\r Vibrio cholerae\r O139 infection

    Dutta, D.   Bhattacharya, S. K.   Bhattacharya, M. K.   Deb, A.   Deb, M.   Manna, B.   Moitra, A.   Mukhopadhyay, A. K.   Nair, G. B.  

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