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Now showing items 65 - 80 of 122

  • The DAMA/LIBRA apparatus

    Bernabei, R.   Belli, P.   Busstti, A.   Cappella, F.   Cerulli, R.   Dai, C. J.   d'Angelo, A.   He, H. L.   Incicchitti, A.   Kuang, H. H.   Ma, J. M.   Mattei, A.   Montecchia, F.   Nozzoli, F.   Prosperi, D.   Sheng, X. D.   Ye, Z. P.  

    The similar or equal to 250 kg highly radiopure NaI(Tl) DAMA/LIBRA apparatus, running at the Gran Sasso National Laboratory (LNGS) of the INFN, is described. (C) 2008 Elsevier B.V. All rights reserved.
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  • Assessing the performance under ionising radiation of lead tungstate scintillators for EM calorimetry in the CLAS12 Forward Tagger

    Fegan, S.   Auffray, E.   Battaglieri, M.   Buchanan, E.   Caiffi, B.   Celentano, A.   Colaneri, L.   D'Angelo, A.   De Vita, R.   Dormenev, V.   Fanchini, E.   Lanza, L.   Novotny, R. W.   Parodi, F.   Rizzo, A.   Sokhan, D.   Tarasov, I.   Zonta, I.  

    The well-established technology of electromagnetic calorimetry using Lead Tungstate crystals has recently seen an upheaval, with the closure of one of the most experienced large-scale suppliers of such crystals, the Bogoroclitsk Technical Chemical Plant (BTCP), which was instrumental in the development of mass production procedures for PWO-II, the current benchmark for this scintillator. Obtaining alternative supplies of Lead Tungstate crystals matching the demanding specifications of contemporary calorimeter devices now presents a significant challenge to detector research and development programmes. In this paper we describe a programme of assessment carried out for the selection, based upon the performance under irradiation, of Lead Tungstate crystals for use in the Forward Tagger device, part of the CLAS12 detector in Hall B at Jefferson Lab. The crystals tested were acquired from SICCAS, the Shanghai Institute of Ceramics, Chinese Academy of Sciences. The tests performed are intended to maximise the performance of the detector within the practicalities of the crystal manufacturing process. Results of light transmission, before and after gamma ray irradiation, are presented and used to calculate dk, the induced radiation absorption coefficient, at 420 nm, the peak of the Lead Tungstate emission spectrum. Results for the SICCAS crystals are compared with identical measurements carried out on Bogoroditsk samples, which were acquired for the Forward Tagger development program before the closure of the facility. Also presented are a series of tests performed to determine the feasibility of recovering radiation damage to the crystals using illumination from an LED, with such illumination available in the Forward Tagger from a light monitoring system integral to the detector. 2015 Elsevier B.V. All rights reserved,
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  • Dark Matter Particles in the Galactic Halo

    Bernabei, R.   Belli, P.   Montecchia, F.   Nozzoli, F.   Cappella, F.   d'Angelo, A.   Incicchitti, A.   Prosperi, D.   Cerulli, R.   Dai, C. J.   He, H. L.   Kuang, H. H.   Ma, J. M.   Sheng, X. D.   Ye, Z. P.  

    Arguments on the investigation of the Dark Matter particles in the galactic halo are addressed. Recent results obtained by exploiting the annual modulation signature are summarized and the perspectives are discussed.
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  • in the deep-inelastic regime with CLAS

    Zhao, B.   Kim, A.   Joo, K.   Bedlinskiy, I.   Kim, W.   Kubarovsky, V.   Ungaro, M.   Adhikari, S.   Akbar, Z.   Angelini, G.   Avakian, H.   Ball, J.   Baltzell, N.A.   Barion, L.   Bashkanov, M.   Battaglieri, M.   Batourine, V.   Biselli, A.S.   Boiarinov, S.   Briscoe, W.J.   Brooks, W.K.   Burkert, V.D.   Carman, D.S.   Celentano, A.   Chatagnon, P.   Chetry, T.   Ciullo, G.   Clark, L.   Clary, B.A.   Cole, P.L.   Contalbrigo, M.   Crede, V.   D'Angelo, A.   Dashyan, N.   De Vita, R.   De Sanctis, E.   Defurne, M.   Deur, A.   Diehl, S.   Djalali, C.   Dupre, R.   Egiyan, H.   Ehrhart, M.   El Alaoui, A.   El Fassi, L.   Eugenio, P.   Filippi, A.   Forest, T.A.   Gavalian, G.   Ghandilyan, Y.   Gilfoyle, G.P.   Girod, F.X.   Golovatch, E.   Gothe, R.W.   Griffioen, K.A.   Guidal, M.   Guo, L.   Hafidi, K.   Hakobyan, H.   Harrison, N.   Hattawy, M.   Heddle, D.   Hicks, K.   Holtrop, M.   Ilieva, Y.   Ireland, D.G.   Ishkhanov, B.S.   Isupov, E.L.   Jenkins, D.   Jo, H.S.   Johnston, S.   Kabir, M.L.   Keller, D.   Khachatryan, G.   Khachatryan, M.   Khandaker, M.   Klein, A.   Klein, F.J.   Kuhn, S.E.   Kuleshov, S.V.   Lanza, L.   Lenisa, P.   Livingston, K.   MacGregor, I.J.D.   Marchand, D.   Markov, N.   McKinnon, B.   Meyer, C.A.   Meziani, Z.E.   Mirazita, M.   Mokeev, V.   Montgomery, R.A.   Munoz Camacho, C.   Nadel-Turonski, P.   Niccolai, S.   Niculescu, G.   Osipenko, M.   Ostrovidov, A.I.   Paolone, M.   Paremuzyan, R.   Park, K.   Pogorelko, O.   Price, J.W.   Prok, Y.   Protopopescu, D.   Ripani, M.   Rizzo, A.   Rosner, G.   Rossi, P.   Sabatié, F.   Salgado, C.   Schumacher, R.A.   Sharabian, Y.G.   Skorodumina, Iu.   Smith, G.D.   Sokhan, D.   Sparveris, N.   Stepanyan, S.   Strakovsky, I.I.   Strauch, S.   Taiuti, M.   Tan, J.A.   Voskanyan, H.   Voutier, E.   Wang, R.   Wei, X.   Wood, M.H.   Zachariou, N.   Zhang, J.   Zhao, Z.W.  

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  • Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis

    Latella, G.   Vetuschi, A.   Sferra, R.   Zanninelli, G.   D'Angelo, A.   Catitti, V.   Caprilli, R.   Flanders, K. C.   Gaudio, E.  

    Transforming growth factor-beta (TGF-beta)/Smad3 signalling plays a central role in tissue fibrogenesis, acting as a potent stimulus of extracellular matrix (ECM) protein accumulation. The aim of this study was to evaluate the potential role of Smad3 in the pathogenesis of colonic fibrosis induced by trinitrobenzene sulfonic acid (TNBS) in Smad3 null mice. Chronic colitis-associated fibrosis was induced in 15 Smad3 null and 13 wild-type mice by intra-rectal administration of TNBS. Each mouse received an incremental dose of TNBS (0.5-1.0 mg per week) over a 6-week period. The colon was excised for macroscopic examination and histological, morphometric and immunohistochemical analyses. For immunohistochemistry, alpha-smooth muscle actin (alpha-SMA), collagen types I-III, TGF-beta 1, connective tissue growth factor (CTGF), Smad3, Smad7, and CD3 antibodies were used. At macroscopic examination, the colon of Smad3 wild-type mice appeared significantly harder, thicker and shorter than that of the Smad3 null mice. Of the wild-type mice, 50% presented colonic adhesions and strictures. Histological and morphometric evaluation revealed a significantly higher degree of colonic fibrosis and accumulation of collagen in the Smad3 wild-type compared to null mice, whereas the degree of colonic inflammation did not differ between the two groups of mice. Immunohistochemical evaluation showed a marked increase in CTGF, collagen I-III, TGF-beta and Smad3 staining in the colon of Smad3 wild-type compared to null mice, whereas Smad7 was increased only in null mice. These results indicate that Smad3 loss confers resistance to the development of TNBS-induced colonic fibrosis. The reduced fibrotic response appears to be due to a reduction in fibrogenic mesenchymal cell activation and ECM production and accumulation. Smad3 could be a novel target for potential treatment of intestinal fibrosis, especially in inflammatory bowel disease. Eur J Clin Invest 2009; 39 (2): 145-156.
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  • Comparison of three commercial assays for the determination of prothrombin fragment l&2 in healthy subjects and in patients on oral anticoagulant treatment: P. Della Valle, L. Crippa, S. Vigano' D'Angelo E. Pattarini, G. Mazzola, , A. D'Angelo. IRCCS H.S Raffaele, Milano

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  • HPLC method for the determination of total homocysteine and definition of reference values: S. Vigano' D'Angelo, I. Fermo, R. Paroni, A. D'Angelo. IRCCS H.S. Raffaele, Milano

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  • Homocysteine (HCy) levels in young patients with venous thromboembolism: S.Viqano' D'Angelo, I.Fermo, R.Paroni, A. D'Angelo. IRCCS H.S.Raffaele, Milano

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  • Color based soft biometry for hooligans detection

    D'Angelo, A.   Dugelay, J.-L.  

    Biometric systems based on human traits like fingerprinting, face, iris, etc., even widely explored in literature, cannot be used in scenarios like video surveillance of crowded envinroments. A different class of biometry, usually referred as soft biometry, including individual's height, weight, skin color, clothes color, trajectory, etc., can be more easily extracted from cameras in a large network to provide some useful information about the users. In this work we focus our attention on the color of human clothes. We apply color based soft biometric to a specific scenario, i.e. to prevent hooligans fights, based on the color of the clothes they wear. A video surveillance system able to quickly identify the presence of rival teams fans in a specific location would be helpful in avoiding vandalism and destructive behaviour.
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  • A History of the Italians in New Mexicoby Frederick G. Bohme;Son of Italyby Pasquale D'Angelo

    Review by: ANDREW ROLLE  

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  • Diprosopia/Dicephalia in Calves in Northern Italy: Clinical and Aetio-Pathological Features

    Biasibetti, E.   D'Angelo, A.   Bellino, C.   Gay, L.   Gianella, P.   Capucchio, M. T.  

    Cephalic parapagia, a rare congenital anomaly caused by the fusion of two monozygotic embryos, is characterized by a single body and a spectrum of duplication of craniofacial structures. The authors describe the clinical and pathological aspects of the parapagus conjoined twin defect in nine calves referred to the Department of Animal Pathology, Turin, between 1999 and 2009. The majority of the calves (eight cases) presented two snouts that shared three or four eyes (diprosopia); one calf presented two separate skulls fused at the foramen magnum (dicephalia). Bilateral inferior brachygnathia was observed in four calves. Post-mortem examination of the skull revealed complete brain duplication with fusion at the caudal portion of the brainstem in all calves. Histological features of the cerebral hemispheres and brainstem were normal; moderate disorganization of the cerebellar cortex was noted in two cases. Cardiac malformations were observed in three calves. No aetiologic cause was determined. This article underscores the importance of diprosopia in cattle species and suggests the need for more detailed investigations to better understand its pathogenesis.
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  • Intraperitoneal insulin therapy modulates in vivo thrombin activity in insulin-dependent (type I) diabetics: A. D'Angelo, P. Micossi, E. Orsi, S. Testa, S. Vigano ‘D’ Angelo, G. Pozza. Servizio di Coagulazione e Cattedra di Clinica Medica, Istituto Scientifico H.S. Raffaele, Milano, Italy

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  • Patterning at the nanoscale: Atomic force microscopy and extreme ultraviolet interference lithography

    Parisse, P.   Luciani, D.   D'Angelo, A.   Santucci, S.   Zuppella, P.   Tucceri, P.   Reale, A.   Ottaviano, L.  

    We present our recent results achieved using atomic force microscopy nano-oxidation and nano-indentation of thin layers of polymers, and using extreme ultraviolet interference lithography. We focus our attention on the advantages and drawbacks of Such lithographic techniques. In particular, we show the possibility to create patterns on polymers compatible with the conventional metal deposition and lift-off processes on submicrometer scale (EUV-IL and nano-indentation) and we experimentally confirm the theoretical prediction on the strong dependence of the oxidation process to the sample conductivity. (c) 2009 Elsevier B.V. All rights reserved.
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  • The effect of an adventure race on lymphocyte and neutrophil death

    Levada-Pires, Adriana Cristina   Fonseca, C. E. R.   Hatanaka, E.   Alba-Loureiro, T.   D'Angelo, A.   Velhote, F. B.   Curi, R.   Pithon-Curi, T. C.  

    The effect of an adventure race (Ecomotion Pr), which lasted for 4-5 days, on neutrophil and lymphocyte death from elite athletes was investigated. Blood was collected from 11 athletes at rest and after the adventure race. The following parameters of cell death were measured in neutrophils and lymphocytes: cell membrane integrity, DNA fragmentation, mitochondrial transmembrane depolarization and reactive oxygen species (ROS) production. Phagocytosis capacity was also evaluated in neutrophils. The adventure race raised the proportion of cells with the loss of membrane integrity; lymphocytes by 14% and neutrophils by 16.4%. The proportion of lymphocytes with DNA fragmentation (2.9-fold) and mitochondrial transmembrane depolarization (1.5-fold) increased. However, these parameters did not change in neutrophils. ROS production remained unchanged in lymphocytes, whereas an increase by 2.2-fold was found in neutrophils due to the race. Despite these changes, the phagocytosis capacity did not change in neutrophils after the race. In conclusion, the Ecomotion Pr race-induced neutrophil death by necrosis (as indicated by the loss of membrane integrity) and led to lymphocyte death by apoptosis (as indicated by increase DNA fragmentation and depolarization of mitochondrial membrane).
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  • Late onset and rapid progression of cerebellar abiotrophy in a domestic shorthair cat

    Biolatti, C.   Gianella, P.   Capucchio, M. T.   Borrelli, A.   D'Angelo, A.  

    A two-year-old male domestic shorthair cat was seen because of sudden onset of incoordination and tremors that had rapidly worsened over five days. Neurological examination revealed severe cerebellar ataxia, intention tremors and bilaterally decreased menace response. Blood work evaluation included a complete cell blood count (CBC), serum biochemistry profile, urinalysis, faecal flotation, cerebrospinal fluid (CSF) analysis and retroviral testing. Except for testing positive for feline immunodeficiency virus (FIV) antibodies, all other results were within the normal range. The patient was euthanased two days later because of progression of clinical signs, and a necropsy was performed. Histologically, lesions were limited to the cerebellum and consistent with cerebellar abiotrophy. No secondary diseases that could explain the rapid development of clinical signs were found. It was considered unlikely that cerebellar degeneration was related to FIV positivity, as virus invasion of the central nervous system (CNS) is mainly limited to the cerebral cortex. This case report is the first to describe late onset and rapid progression cerebellar abiotrophy in a cat.
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  • New results from DAMA/LIBRA

    Bernabei, R.   Belli, P.   Cappella, F.   Cerulli, R.   Dai, C. J.   d'Angelo, A.   He, H. L.   Incicchitti, A.   Kuang, H. H.   Ma, X. H.   Montecchia, F.   Nozzoli, F.   Prosperi, D.   Sheng, X. D.   Wang, R. G.   Ye, Z. P.  

    DAMA/LIBRA is running at the Gran Sasso National Laboratory of the I.N.F.N. Here the results obtained with a further exposure of 0.34 ton x yr are presented. They refer to two further annual cycles collected one before and one after the first DAMA/LIBRA upgrade occurred on September/October 2008. The cumulative exposure with those previously released by the former DAMA/NaI and by DAMA/LIBRA is now 1.17 ton x yr, corresponding to 13 annual cycles. The data further confirm the previous positive results obtained investigating the presence of Dark Matter (DM) particles in the galactic halo by means of the model independent Dark Matter annual modulation signature; the confidence level is now 8.9 sigma for the cumulative exposure. In particular, with the cumulative exposure the modulation amplitude of the single-hit events in the (2-6) keV energy interval measured in NaI(Tl) target is (0.0116 +/- 0.0013) cpd/kg/keV; the measured phase is (146 +/- 7) days and the measured period is (0.999 +/- 0.002) yr, values well in agreement with those expected for the DM particles.
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