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Now showing items 33 - 48 of 122

  • Non-paulian Nuclear Processes in Highly Radiopure NaI(Tl): Status and Perspectives

    Bernabei, R.   Belli, P.   Cappella, F.   Cerulli, R.   Dai, C. J.   d'Angelo, A.   He, H. L.   Incicchitti, A.   Kuang, H. H.   Ma, X. H.   Montecchia, F.   Nozzoli, F.   Prosperi, D.   Sheng, X. D.   Ye, Z. P.  

    Searches for non-paulian nuclear processes, i.e. processes normally forbidden by the Pauli-Exclusion-Principle (PEP) with highly radiopure NaI(Tl) scintillators allow the test of this fundamental principle with high sensitivity. Status and perspectives are addressed.
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  • Prospects for gamma gamma physics at DA Phi NE-2

    Archilli, F.   Babusci, D.   D'Angelo, A.   Messi, R.   Moriccian, D.   Quintieri, L.  

    These pages provide physics motivation of the gamma gamma program at DA Phi NE-2 project.
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  • Measurement of Sigma beam asymmetry in pi(0) photoproduction off the neutron in the second and third resonances region

    Di Salvo, R.   Fantini, A.   Mandaglio, G.   Mammoliti, F.   Bartalini, O.   Bellini, V.   Bocquet, J. P.   Casano, L.   D'angelo, A.   Didelez, J. P.   Franco, D.   Gervino, G.   Ghio, F.   Giardina, G.   Girolami, B.   Giusa, A.   Guidal, M.   Hourany, E.   Kunne, R.   Lapik, A.   Sandri, P. Levi   Lleres, A.   Manganaro, M.   Moricciani, D.   Mushkarenkov, A. N.   Nedorezov, V.   Randieri, C.   Rebreyend, D.   Rudnev, N.   Russo, G.   Schaerf, C.   Sperduto, M. L.   Sutera, M. C.   Turinge, A.   Vegna, V.   Fix, A.   Kamalov, S. S.   Tiator, L.  

    The Sigma beam asymmetry in the photoproduction of neutral pions from quasi-free nucleons in a deuteron target was measured for the first time between 0.60 and 1.50 GeV, with the GRAAL polarized and tagged photon beam. The asymmetry values from the quasi-free proton were found equal to the ones extracted from a pure proton target. The asymmetries from quasi-free proton and quasi-free neutron were found equal up to 0.82 GeV and substantially different at higher energies. The results are compared with recent partial-wave analyses.
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  • Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review

    D'Angelo, A.  

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  • First results on nucleon resonance photocouplings from the γp → π+π−p reaction

    Golovatch, E.   Burkert, V.D.   Carman, D.S.   Gothe, R.W.   Hicks, K.   Ishkhanov, B.S.   Mokeev, V.I.   Pasyuk, E.   Adhikari, S.   Akbar, Z.   Amaryan, M.J.   Avakian, H.   Ball, J.   Barion, L.   Bashkanov, M.   Battaglieri, M.   Bedlinskiy, I.   Biselli, A.S.   Boiarinov, S.   Briscoe, W.J.   Cao, F.   Celentano, A.   Chatagnon, P.   Chetry, T.   Ciullo, G.   Clark, L.   Clary, B.A.   Cole, P.L.   Contalbrigo, M.   Crede, V.   D'Angelo, A.   Dashyan, N.   De Vita, R.   De Sanctis, E.   Defurne, M.   Deur, A.   Diehl, S.   Djalali, C.   Dugger, M.   Dupre, R.   Egiyan, H.   Ehrhart, M.   El Alaoui, A.   El Fassi, L.   Elouadrhiri, L.   Eugenio, P.   Fedotov, G.   Fersch, R.   Filippi, A.   Ghandilyan, Y.   Gilfoyle, G.P.   Giovanetti, K.L.   Girod, F.X.   Glazier, D.I.   Griffioen, K.A.   Guidal, M.   Guo, L.   Hafidi, K.   Hakobyan, H.   Harrison, N.   Hattawy, M.   Heddle, D.   Holtrop, M.   Ilieva, Y.   Ireland, D.G.   Isupov, E.L.   Jenkins, D.   Jo, H.S.   Johnston, S.   Joo, K.   Kabir, M.L.   Keller, D.   Khachatryan, G.   Khachatryan, M.   Khandaker, M.   Kim, W.   Klein, A.   Klein, F.J.   Kubarovsky, V.   Lanza, L.   Lenisa, P.   Livingston, K.   MacGregor, I.J.D.   Marchand, D.   Markov, N.   McKinnon, B.   Meyer, C.A.   Montgomery, R.A.   Movsisyan, A.   Munoz Camacho, C.   Nadel-Turonski, P.   Niccolai, S.   Niculescu, G.   Osipenko, M.   Ostrovidov, A.I.   Paolone, M.   Paremuzyan, R.   Park, K.   Pogorelko, O.   Price, J.W.   Prok, Y.   Protopopescu, D.   Ripani, M.   Riser, D.   Rizzo, A.   Rosner, G.   Sabatié, F.   Salgado, C.   Schumacher, R.A.   Sharabian, Y.G.   Skorodumina, Iu.   Smith, G.D.   Sober, D.I.   Sokhan, D.   Sparveris, N.   Strakovsky, I.I.   Strauch, S.   Taiuti, M.   Tan, J.A.   Tyler, N.   Ungaro, M.   Voskanyan, H.   Voutier, E.   Wang, R.   Wei, X.   Wood, M.H.   Zachariou, N.   Zhang, J.   Zhao, Z.W.  

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  • Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

    Maugeri, N.   Campana, L.   Gavina, M.   Covino, C.   De Metrio, M.   Panciroli, C.   Maiuri, L.   Maseri, A.   D'Angelo, A.   Bianchi, M. E.   Rovere-Querini, P.   Manfredi, A. A.  

    BackgroundIncreasing evidence implicates both platelets and neutrophils in the formation, stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps (NETs) play a key role. The early events in the deregulated cross-talk between platelets and neutrophils are poorly characterized. ObjectivesTo identify at the molecular level the mechanism through which platelets induce the generation of NETs in sterile conditions. Patients/MethodsThe presence of NETs was determined in 26 thrombi from patients with acute myocardial infarction by immunohistochemistry and immunofluorescence and markers of NETs assessed in the plasma. In vitro NET generation was studied in static and in physiological flow conditions. ResultsCoronary thrombi mainly consist of activated platelets, neutrophils, and NETs in close proximity of platelets. Activated platelets commit neutrophils to NET generation. The event abates in the presence of competitive antagonists of the high mobility group box 1 (HMGB1) protein. Hmgb1(-/-) platelets fail to elicit NETs, whereas the HMGB1 alone commits neutrophils to NET generation. Integrity of the HMGB1 receptor, Receptor for Advanced Glycation End products (RAGE), is required for NET formation, as assessed using pharmacologic and genetic tools. Exposure to HMGB1 prevents depletion of mitochondrial potential, induces autophagosome formation, and prolongs neutrophil survival. These metabolic effects are caused by the activation of autophagy. Blockade of the autophagic flux reverts platelet HMGB1-elicited NET generation. ConclusionsActivated platelets present HMGB1 to neutrophils and commit them to autophagy and NET generation. This chain of events may be responsible for some types of thromboinflammatory lesions and indicates novel paths for molecular intervention.
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  • Taladon: a polarized and tagged gamma ray beam

    Babusci, D.   Cima, E.   Iannarelli, M.   Turri, E.   Basti, F.   Halpern, I.   Casano, L.   D'Angelo, A.   Moricciani, D.   Picozza, P.G.   Schaerf, C.   Girolami, B.  

    The authors present the first measurements of the gamma-ray beam energy resolution obtained with a new tagging system for the Ladon facility on the storage ring Adone at Frascati. A resolution of the order of 3% in the energy region of 30-80 MeV is obtained in accordance with predictions
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  • Measurement of the nuclear multiplicity ratio for K(s)(0) hadronization at CLAS RID D-4072-2011

    Daniel, A.   Hicks, K.   Brooks, W. K.   Hakobyan, H.   Adhikari, K. P.   Adikaram, D.   Aghasyan, M.   Amarian, M.   Anghinolfi, M.   Avakian, H.   Baghdasaryan, H.   Battaglieri, M.   Batourine, V.   Bedlinskiy, I.   Bennett, R. P.   Biselli, A. S.   Bookwalter, C.   Briscoe, W. J.   Burkert, V. D.   Carman, D. S.   Casey, L.   Celentano, A.   Chandavar, S.   Cole, P. L.   Contalbrigo, M.   Crede, V.   D'Angelo, A.   Dashyan, N.   De Vita, R.   De Sanctis, E.   Deur, A.   Dey, B.   Dickson, R.   Djalali, C.   Dodge, G. E.   Doughty, D.   Egiyan, H.   El Fassi, L.   Elouadrhiri, L.   Eugenio, P.   Fedotov, G.   Fegan, S.   Gabrielyan, M. Y.   Gevorgyan, N.   Gilfoyle, G. P.   Giovanetti, K. L.   Girod, F. X.   Goetz, J. T.   Gohn, W.   Golovatch, E.   Gothe, R. W.   Griffioen, K. A.   Guidal, M.   Guo, L.   Hanretty, C.   Heddle, D.   Holtrop, M.   Hyde, C. E.   Ilieva, Y.   Ireland, D. G.   Ishkhanov, B. S.   Isupov, E. L.   Jawalkar, S. S.   Jo, H. S.   Joo, K.   Kalantarians, N.   Keller, D.   Khandaker, M.   Khetarpal, P.   Kim, A.   Kim, W.   Klein, A.   Klein, F. J.   Kubarovsky, V.   Kuleshov, S. V.   Kuznetsov, V.   Lu, N. Y.   MacGregor, I. J. D.   Mao, Y.   Markov, N.   Mayer, M.   McAndrew, J.   McKinnon, B.   Meyer, C. A.   Mineeva, T.   Mirazita, M.   Mokeev, V.   Moutarde, H.   Munevar, E.   Nadel-Turonski, P.   Ni, A.   Niccolai, S.   Niculescu, G.   Niculescu, I.   Osipenko, M.   Ostrovidov, A. I.   Paolone, M.   Pappalardo, L.   Paremuzyan, R.   Park, K.   Park, S.   Pasyuk, E.   Pereira, S. Anefalos   Phelps, E.   Pisano, S.   Pogorelko, O.   Pozdniakov, S.   Price, J. W.   Procureur, S.   Protopopescu, D.   Raue, B. A.   Ricco, G.   Rimal, D.   Ripani, M.   Rosner, G.   Rossi, P.   Sabatie, F.   Saini, M. S.   Salgado, C.   Schott, D.   Schumacher, R. A.   Seraydaryan, H.   Sharabian, Y. G.   Smith, G. D.   Sober, D. I.   Sokhan, D.   Stepanyan, S. S.   Stepanyan, S.   Strauch, S.   Taiuti, M.   Tang, W.   Taylor, C. E.   Tkachenko, S.   Ungaro, M.   Vernarsky, B.   Vineyard, M. F.   Voskanyan, H.   Voutier, E.   Watts, D. P.   Weinstein, L. B.   Weygand, D. P.   Wood, M. H.   Zana, L.   Zachariou, N.   Zhao, B.   Zhao, Z. W.  

    The influence of cold nuclear matter on lepto-production of hadrons in semi-inclusive deep inelastic scattering is measured using the CLAS detector in Hall B at Jefferson Lab and a 5.014 GeV electron beam. We report the K(s)(0) multiplicity ratios for targets of C, Fe, and Pb relative to deuterium as a function of the fractional virtual photon energy z transferred to the K(s)(0) and the transverse momentum squared p(T)(2). of the K(s)(0). We find that the multiplicity ratios for K(s)(0) are reduced in the nuclear medium at high z and low p(T)(2), with a trend for the K(s)(0) momentum to be broadened in the nucleus for large p(T)(2). (C) 2011 Elsevier B.V. All rights reserved.
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  • Handbook of Obstetric Anaesthesia: C. M. Palmer, R. D'Angelo, M. J. Peach (eds) Bios Scientific Publishers: Oxford, UK, 2002, 265 pp; indexed, illustrated ISBN: 1-85996-232-7; Price £60.00

    Camorcia, M.  

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  • Glyco‐metabolic control, inflammation markers and cardiovascular outcomes in type 1 and type 2 diabetic patients on insulin pump or multiple daily injection (Italico study)

    Derosa, G.   Catena, G.   Scelsi, L.   D'Angelo, A.   Raddino, R.   Cosentino, E.   Maggi, A.   Pasini, G.   Borghi, C.   Maffioli, P.  

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  • No role for neutrons, muons and solar neutrinos in the DAMA annual modulation results

    Bernabei, R.   Belli, P.   Cappella, F.   Caracciolo, V.   Cerulli, R.   Dai, C. J.   d'Angelo, A.   d'Angelo, S.   Di Marco, A.   He, H. L.   Incicchitti, A.   Kuang, H. H.   Ma, X. H.   Montecchia, F.   Sheng, X. D.   Wang, R. G.   Ye, Z. P.  

    This paper summarizes in a simple and intuitive way why the neutrons, the muons and the solar neutrinos cannot give any significant contribution to the DAMA annual modulation results. A number of these elements have already been presented in individual papers; they are recalled here together with few simple considerations which demonstrate the incorrectness of the claim reported in Davis (PRL 113: 081302, 2014).
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  • Effect of in vivo administration of naloxone on ATP-ase's enzyme systems of synaptic plasma membranes from rat cerebral cortex

    Gorini, A.   Rancati, A.   D'Angelo, A.   Devecchi, E.   Villa, R. F.  

    Naloxone is a specific competitive antagonist of morphine, acting on opiate receptors, located on neuronal membranes. The effects of in vivo administration of naloxone on energy-consuming non-mitochondrial ATP-ases were studied in two different types of synaptic plasma membranes from rat cerebral cortex, known to contain a high density of opiate receptors. The enzyme activities of Na+, K+-ATP-ase, Ca2+, Mg2+-ATP-ase and Mg2+-ATP-ase and of acetylcholinesterase (AChE) were evaluated on synaptic plasma membranes obtained from control and treated animals with effective dose of naloxone (12mug cntdot kg-1 i.m. 30 minutes). In control (vehicle-treated) animals specific enzyme activities assayed on these two types of synaptic plasma membranes are different, being higher on synaptic plasma membranes of II type than of I type, because the first fraction is more enriched in synaptic plasma membranes. The acute treatment with naloxone produced a significant decrease in Ca2+,Mg2+-ATP-ase activity and an increase in AChE activity, only in synaptic plasma membranes of II type. The decrease of Ca2+,Mg2+-ATP-ase enzymatic activity and the increased AChE activity are related to the interference of the drug on Ca2+ homeostasis in synaptosoplasm, that leads to the activation of calcium-dependent processes, i.e. the extrusion of neurotransmitter. These findings give further evidence that pharmacodynamic characteristics of naloxone are also related to increase (Ca2+)i, interfering with enzyme systems (Ca2+,Mg2+-ATP-ase) and that this drug increases acetylcholine catabolism in synaptic plasma membranes of cerebral cortex.
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  • Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in diabetic and healthy subjects

    Derosa, G.   D'Angelo, A.   Tinelli, C.   Devangello, E.   Consoli, A.   Miccoli, R.   Penno, G.   Del Prato, S.   Paniga, S.   Cicero, A. F. G.  

    Objectives. - We hypothesized that molecules active in vascular remodeling (i.e. MMPs and their TIMPs) could be modified in diabetic patients, as indirect markers of the diabetes related generalized abnormality of vascular activity. To test this hypothesis, we measured the plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in type 2 diabetic patients and in healthy subjects. Methods. - We enrolled 181 diabetic patients and 165 controls. We measured body mass index (BMI), glycosylated hemoglobin (HbA(1c)) fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Het) fibrinogen (Fg), high sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Results. - A significant increase (P < 0.0001) of BMI, HbA(1c), FPG, FPT, HOMA index, SBP, DBP, TC, LDL-C, Tg, Lp(a), PAl-1, Hct, Fg, and hs-CRP was present in the diabetic group, with a significant decrease (P < 0.000 1) of HDL-C levels compared to healthy subjects. MMP-2 and MMP-9 levels were significantly higher (P < 0.0001) in diabetic patients. Significant TIMP-1, and TIMP-2 increase was also observed (P < 0.000 1) in the diabetic group. Conclusion. - Plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 are increased in diabetic patients which may reflect abnormal extracellular matrix (ECM) Metabolism. (c) 2007 Elsevier Masson SAS. All rights reserved.
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  • Ex vivo evidence that effective inhibition of prothrombin activation follows reduction of plasma factor II in patients starting oral anticoagulant treatment: P. Della Valle, L. Crippa, E. Pattarini, G. Paolillo, A. D'Angelo. Istituto Scientifico I.R.C.C. S. H.S. Raffaele, Milano, Italy

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  • Physics and astrophysics with dark matter particles

    Bernabei, R.   Belli, P.   Montecchia, F.   Nozzoli, F.   Cappella, F.   d'Angelo, A.   Incicchitti, A.   Prosperi, D.   Cerulli, R.   Dai, C. J.   He, H. L.   Kuang, H. H.   Ma, J. M.   Ye, Z. P.  

    The DAMA/NaI set-up has investigated the annual modulation signature over seven annual cycles achieving 6.3 sigma C.L. model independent evidence for the presence of a Dark Matter particle component in the galactic halo. Some of the Physics and Astrophysics topics which can be addressed by DAMA/LIBRA axe also introduced.
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  • Evaluation of circulating endothelial cells, VEGF and VEGFR2 serum levels in patients with chronic myeloproliferative diseases

    Alonci, A.   Allegra, A.   Bellomo, G.   Penna, G.   D'Angelo, A.   Quartarone, E.   Musolino, C.  

    Authors evaluated some markers of angiogenetic activity in patients with chronic myeloproliferative diseases (CMDs). In this study by using a cytofluorimetric analysis we evaluated circulating endothelial progenitor cells (EPCs) in patients with chronic myeloproliferative disease. Moreover, in the same group of subjects, we evaluated serum levels of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR2). In our patients, we have found an increase in the number of endothelial progenitor cells in primary myelofibrosis (PMF) and polycythaemia vera (PV) patients, while an increase of circulating endothelial cells (CECs) was found in all patients with CMD. Moreover, we found higher serum levels of VEGF with respect to control subjects in every group of patients with CMD, and a not significant reduction of VEGFR2 levels in essential thrombocythaemia (ET) patients. A correlation was also found in PV patients between VEGF levels and erythrocyte number and in IMF subjects with the count of white cells. Our data suggest that some markers of angiogenesis are activated in CMD patients and angiogenesis may have a role in the pathophysiology of chronic myeloproliferative disorders. Copyright (C) 2008 John Wiley & Sons, Ltd.
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