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Now showing items 1 - 2 of 2

  • Neurovirulence of Varicella and the Live Attenuated Varicella Vaccine Virus

    Corey Horien   Charles Grose  

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  • Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol

    Corey Horien   Scuddy Fontenelle IV   Kohrissa Joseph   Nicole Powell   Chaela Nutor   Diogo Fortes   Maureen Butler   Kelly Powell   Deanna Macris   Kangjoo Lee   Abigail S. Greene   James C. McPartland   Fred R. Volkmar   Dustin Scheinost   Katarzyna Chawarska   R. Todd Constable  

    Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings.
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