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Now showing items 1 - 16 of 18

  • OccVis: a visual analytics system for occultation data

    Cheng, Shiyu   Shan, Guihua   Liu, Jun   Gao, Yang   Wei, Ping   Bai, Weihua   Zhao, Danyang  

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  • Reference Module in Biomedical Sciences || Microfluidics for Biomedical Applications

    Cheng, Shiyu  

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  • Self-Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation

    Cheng, Shiyu   Jin, Yu   Wang, Nuoxin   Cao, Feng   Zhang, Wei   Bai, Wei   Zheng, Wenfu   Jiang, Xingyu  

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  • The complete mitochondrial genome of Blattisocius keegani Fox (Acari: Mesostigmata) and the related phylogenetic analyses

    Wu, Lingzhi   Cheng, Shiyu   Guo, Liuling   Mo, Weifen   Xia, Bin   Zou, Zhiwen  

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  • Biomaterials: Self-Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation (Adv. Mater. 28/2017)

    Cheng, Shiyu   Jin, Yu   Wang, Nuoxin   Cao, Feng   Zhang, Wei   Bai, Wei   Zheng, Wenfu   Jiang, Xingyu  

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  • Formal equivalence checking and design debugging: By Shi-Yu Huang and Kwang-Ting (Tim) Cheng. Kluwer Academic Publishers, Boston, MA. (1998). 229 pages. $106.50, NLG 245.00, GBP 72.50

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  • A strategy for rapid and facile fabrication of controlled,layered blood vessel-like structures

    Wang, Nuoxin   Tang, Lixue   Zheng, Wenfu   Peng, Yunhu   Cheng, Shiyu   Lei, Yifeng   Zhang, Lingmin   Hu, Bingfeng   Liu, Shaoqin   Zhang, Wei   Jiang, Xingyu  

    We develop a rapid and facile method to fabricate tubular scaffolds by a single-step rolling operation. With the aid of fibrin medical glue and a smooth expanded polytetrafluoroethylene (ePTFE) mandrel, we can wrap a piece of flat thin film into a three-dimensional (3D), multi-layered tubular structure with well-controlled diameter, wall thickness, and mechanical strength within 10 min. By patterning different cells in a pre-designed area on the film, after rolling, we can obtain blood vessel-mimicking tissues with well-arranged, multilayered 3D architectures within 70 min. Our strategy provides an excellent platform to rapidly fabricate tubular scaffolds essentially with no equipment and straightforward manipulations.
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  • The complete mitochondrial genome of Blattisocius keegani Fox (Acari:Mesostigmata) and the related phylogenetic analyses

    Wu, Lingzhi   Cheng, Shiyu   Guo, Liuling   Mo, Weifen   Xia, Bin   Zou, Zhiwen  

    Blattisocius Keegan is a genus of predatory mites in the family Blattisociidae, with potential utility as biological control agents. In the present study, Illumina HiSeq was used to sequence the complete mt genome of B. keegani Fox. The mt genome of B. keegani was a circular DNA molecule of 17,314 bp. With a 1,935 bp-long non-coding region, it is the second largest mt genome in Acari. All 37 genes expected to be present in a standard metazoan mitogenome were identified in this genome. Phylogenetic analyses of 28 additional species of Acari were then performed based on the mt genome. Bayesian inference (BI) and Maximum likelihood (ML) algorithm were used to analyse the sequence data. Compared with Limulus polyphemus, rearrangements of 34 genes and changes of three genes orientation (trnE, trnF and trnS(1)) in B. keegani were observed. Additionally, the gene order of the six mesostigmata mites used in the study showed a lack of conserved gene blocks. BI and ML trees based on 13 protein-coding genes suggested that B. keegani was clustered with E. nicholsi and P. persimilis into a Phytoseioidea branch, which was consistent with the traditional classifications result.
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  • The complete mitochondrial genome of Blattisocius keegani Fox (Acari:Mesostigmata) and the related phylogenetic analyses (vol 45,pg 1,2019)

    Wu, Lingzhi   Cheng, Shiyu   Guo, Liuling   Mo, Weifen   Xia, Bin   Zou, Zhiwen  

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  • Reference Module in Biomedical Sciences || Microfluidics for Biomedical Applications

    Cheng, Shiyu  

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  • Formal equivalence checking and design debugging: By Shi-Yu Huang and Kwang-Ting (Tim) Cheng. Kluwer Academic Publishers, Boston, MA. (1998). 229 pages. $106.50, NLG 245.00, GBP 72.50

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  • Differential expression patterns of two delta-9-acyl-CoA desaturases in Thitarodes pui (Lepidoptera:Hepialidae) during different seasons and cold exposure

    Min, Qiang   Cheng, Shiyu   Xi, Jianfei   Xin, Tianrong   Xia, Bin   Zou, Zhiwen  

    Thitarodes pui larvae have a limited distribution in the Tibetan Plateau and are the host of a parasitic fungus, Ophiocordyceps sinensis. Low temperature is a main environmental stress. However, understanding of T.pui cold adaptation mechanisms is insufficient. Delta-9-acyl-CoA desaturase (D9D) is closely correlated with cold adaptation for many organisms. To further understand the cold adaptation processes in T.pui larvae, two D9Ds, TpdesatA and TpdesatB were sequenced, and expression patterns were investigated during different seasons and cold exposure (under 0 degrees C) in the laboratory. The full lengths of two cDNAs are 1,290bp and 1,603bp, and the ORFs encode a polypeptide of 348 and 359 amino acids, respectively. Four transmembrane domains, three conserved histidine residues and five hydrophobic regions exist in these two sequences. The expression level of TpdesatA is up-regulated in the long-term cold exposure and negatively correlated with temperature in seasonal patterns. TpdesatB responds to cold temperature in short-term cold exposure and positively corresponds temporarily in seasonal expression. Two D9Ds may have different substrate specificities, TpdesatA tends to use C16:0 and C18:0 as substrate while TpdesatB prefers C18:0. In conclusion, TpdesatA may play a very important role in T.pui cold tolerance and TpdesatB regulates function in short-term cold exposure and content change of fatty acids in the body.
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  • A Strategy for Rapid Construction of Blood Vessel-Like Structures with Complex Cell Alignments.

    Wang, Nuoxin   Peng, Yunhu   Zheng, Wenfu   Tang, Lixue   Cheng, Shiyu   Yang, Junchuan   Liu, Shaoqin   Zhang, Wei   Jiang, Xingyu  

    A method is developed that can rapidly produce blood vessel-like structures by bonding cell-laden electrospinning (ES) films layer by layer using fibrin glue within 90 min. This strategy allows control of cell type, cell orientation, and material composition in separate layers. Furthermore, ES films with thicker fibers (polylactic-co-glycolic acid, fiber diameter: 3.7 m) are used as cell-seeding layers to facilitate the cell in-growth; those with thinner fibers (polylactic acid, fiber diameter: 1.8 m) are used as outer reinforcing layers to improve the mechanical strength and reduce the liquid leakage of the scaffold. Cells grow, proliferate, and migrate well in the multilayered structure. This design aims at a new type of blood vessel substitute with flexible control of parameters and implementation of functions. =C2=A9 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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  • Self-Adjusting,Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation

    Cheng, Shiyu   Jin, Yu   Wang, Nuoxin   Cao, Feng   Zhang, Wei   Bai, Wei   Zheng, Wenfu   Jiang, Xingyu  

    A self-adjusting, blood vessel-mimicking, multilayered tubular structure with two polymers, poly(epsilon-caprolactone) (PCL) and poly(dl-lactide-co-glycolide) (PLGA), can keep the shape of the scaffold during biodegradation. The inner (PCL) layer of the tube can expand whereas the outer (PLGA) layers will shrink to maintain the stability of the shape and the inner space of the tubular shape both in vitro and in vivo over months. This approach can be generally useful for making scaffolds that require the maintenance of a defined shape, based on FDA-approved materials.
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  • Predictive value of F-18 FDG PET/CT quantization parameters for progression-free survival in patients with diffuse large B-cell lymphoma

    Xie, Mixue   Zhai, Weihao   Cheng, Shiyu   Zhang, Hongdi   Xie, Yanhui   He, Wei  

    Objectives: To evaluate the predictive significance of F-18 FDG PET/CT quantization parameters for progression-free survival (PFS) in patients with diffuse large B cell lymphoma (DLBCL) before chemotherapy. Methods: We conducted a retrospective study involving 60 patients with DLBCL between January 2010 and August 2014 who had undergone F-18 FDG PET/CT scan prior to treatment. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and number of enlarged lymph nodes (>2 cm) were measured. The primary outcome measure was PFS. Spearman rank correlation analysis, univariate and multivariate Cox regression models, receiver operating characteristic (ROC) analysis, and Kaplan-Meir survival curves were used. Results: Spearman analysis determined that the MTV and TLG values were positively related to Ann Arbor stage, National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) score, and lactate dehydrogenase (LDH) level. The number of enlarged lymph nodes was positively related only to LDH level. The SUVmax value and clinical characteristics were not related. Univariate Cox regression determined that the MTV and TLG values, number of enlarged lymph nodes, and NCCN-IPI score were predictive factors. Multivariate Cox regression determined that the MTV and TLG values and number of enlarged lymph nodes predicted PFS independently of the NCCN-IPI score. The SUVmax value was not predictive of PFS. According to the cut-off determined from ROC analysis, lower MTV and TLG values were highly predictive of favorable PFS. Conclusions: In contrast to SUVmax, the MTV and TLG may be significant prognostic markers for PFS in DLBCL.
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  • OccVis: a visual analytics system for occultation data

    Cheng, Shiyu   Shan, Guihua   Liu, Jun   Gao, Yang   Wei, Ping   Bai, Weihua   Zhao, Danyang  

    The FY-3C satellite returns more than 250,000 occultation data each year, each of which records high vertical resolution profiles of various climatic parameters in the range of 0-1000km above the Earth. These long-term, stable, and globally distributed observations can be used to improve climate modeling and analyze trends in spatial climate. However, traditional methods based on small samples meet challenges in analyzing the multi-dimensional occultation data in large volume. In this paper, we developed OccVis-a visual analytics system for multi-dimensional and multi-scale comparative analysis of occultation data. With a novel workflow, a series of data processing methods are proposed to support data correcting, patching, and clustering. Moreover, a matrix view with two modes is presented for overview, and a detail view along with time series view is provided for further analysis. Domain scientists can easily utilize our system to visually and interactively explore multivariable occultation data at different time and space scales. Finally, we conduct case studies in climate modeling of ionosphere and obtain several preliminary results to demonstrate the usage and effectiveness of our system.
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