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Now showing items 81 - 96 of 75449

  • Local control in cardiac EC coupling

    M.B. Cannell   Cherrie H.T. Kong  

    The development of local control theories in cardiac excitation-contraction coupling solved a major problem in the calcium-induced calcium release (CICR) hypothesis. Local control explained how regeneration, inherent in the CICR mechanism, might be limited spatially to enable graded Ca release (and force production). The key lies in the stochastic recruitment of individual calcium release units (couplons or CRUs) where adjacent CRUs are partially uncoupled by the distance between them. In the CRU, individual groups of sarcoplasmic reticulum calcium release channels (RyRs) are very close to the surface membrane where calcium influx, controlled by membrane depolarization, leads to high local Ca levels that enable a high speed response from RyRs that have a very low probability to opening at resting Ca levels. However, calcium diffusion from an activated CRU results in adjacent CRUs being exposed to much lower levels of Ca and probability of activation. This effectively uncouples the CRUs and limits overall regenerative gain to enable stability without compromising sensitivity. Nevertheless, it is still unclear how the CRU terminates its release of calcium on the physiological timescale, and possible mechanisms (and problems) are briefly reviewed. We suggest that modulation in RyR gating may serve to control average SR Ca levels to regulate other metabolic functions of the sarco(endo)plasmic reticulum beyond regulating contractility. This article is part of a special issue entitled "Local Signaling in Myocytes."
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  • HEMOGLOBINA GLICADA E FRUTOSAMINA EM C=C3=83ES COM DIABETES MELLITUS

    Beltrame, Olair Carlos   Locatelli-Dittrich, Rosangela   Laskoski, Luciane Maria   Patricio, Lia Fordiani Lenati   Medeiros, Nina da Cunha   Koch, Mar=C3=ADlia Oliveira  

    Abstract Diabetes mellitus (DM) commonly occurs in dogs, and the laboratorial confirmation is carried out by glycemia test. The diagnosis and monitoring in humans is made by glycated hemoglobin and fructosamine concentrations. The objective of this study was to diagnose DM in 19 dogs, by evaluating seric glucose, glycated hemoglobin and fructosamine concentrations. Six dogs with DM and treated with insulin were assisted during a twelve-month period, by means of the same blood analysis, until the death (three dogs) or glycemic control (three dogs). Glucose, glycated hemoglobin and fructosamine increased in all dogs with DM, and dogs that did not survive presented higher glycated hemoglobin and seric glucose values than those that survived at the last evaluation. The results showed the importance of evaluating glycated hemoglobin and fructosamine in dogs with DM to diagnose and control treatment effectiveness.=09
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  • Vitamin A, C, D, E and B12 levels in leprosy: A case control study

    Kumar, N.   Malhotra, H. S.   Garg, V.   Garg, R. K.   Malhotra, K. P.  

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  • Copious concertos by C. P. E. Bach

    Knights, F.  

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  • The influence of vitamins E and C and exercise on brain aging

    Mock, J. Thomas   Chaudhari, Kiran   Sidhu, Akram   Sumien, Nathalie  

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  • Vitamins A, C, and E May Reduce Intestinal 210Po Levels after Ingestion

    Kemp, Francis W.   Portugal, Frank   Akudugu, John M.   Neti, Prasad V.S.V.   Ferraris, Ronaldo P.   Howell, Roger W.  

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  • THE USE OF VITAMIN C AND E AFTER HEART TRANSPLANT REVISITED

    Esha Sachdev   Jignesh Patel   Michelle Kittleson   Frank Liou   Minh Luu   Fardad Esmailian   David Chang   Lawrence Czer   Jon Kobashigawa  

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  • THE USE OF VITAMIN C AND E AFTER HEART TRANSPLANT REVISITED

    Sachdev, Esha   Patel, Jignesh   Kittleson, Michelle   Liou, Frank   Luu, Minh   Esmailian, Fardad   Chang, David   Czer, Lawrence   Kobashigawa, Jon  

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  • Total Syntheses of (+/-)-Rhodonoids C,D,E,F,and G and Ranhuadujuanine B

    Wu, Hao   Hsung, Richard P.   Tang, Yu  

    Here we describe the divergent, biosynthetically inspired syntheses of (+/-)-rhodonoids C-G and (+/-)-ranhuadujuanine B. The key steps of the Syntheses inelude the construction: of the chromene unit through a formal oxa-[3 + 3] annulation and a biomimetic acid-catalyzed ring Cyclization. Cationic [2 + 2]:cydoadclition is accomplished to form the cyclobutane core of (+/-)-rhcidonoids E and F.
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  • Hepatitis A, B, C, D, E – Welche Therapieoptionen für wen?

    Manns   M.  

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  • C. P. E. BACH SOURCES AT THE LIBRARY OF CONGRESS

    Boomhower, Daniel F.  

    In the course of the first three decades of the twentieth century, Oscar Sonneck and Carl Engel assembled for the Music Division in the Library of Congress a major collection of manuscripts and early printed editions of the music of Carl Philipp Emanuel Bach. This article provides an inventory of these sources, as well as an examination of the provenance of several groupings of manuscripts that reflect common origins. These manuscript sources document the work of copyists closely associated with Bach, including J. F. Hering, Anon. 302, and Anon. 303, who presumably supplied copies of Bach's music to meet the demand stemming from private music making in eighteenth-century Berlin. The manuscripts also provide evidence of the wider interest among eighteenth-century musicians and collectors, reflected in the collection assembled by Friedrich Wilhelm Rust. Additionally, these materials document the collecting activities of several nineteenth-century musicians, including Eduard Grell, Franz Commer, Erich Prieger, and Ludwig Scheibler, and an obscure figure from Chatellerault, France, by the name of Lasserre.
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  • Austro-German instrumental music from Schmelzer to C. P. E. Bach

    McKean   J.  

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  • Antioxidant Vitamin (E&C) Contents in Colostrum of Bangladeshi Women

    Haque, Rubena; Ferdousi, Shahnila; Islam, Sk Nazrul; Sultana, Razia; Ferdousi, Shammi Sultana  

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  • Austro-German instrumental music from Schmelzer to C. P. E. Bach

    McKean, J.  

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  • Procedure—economical enantioselective total syntheses of asperlicins C and E

    Pei-Qiang Huang   Yu Wang   Shi-Peng Luo   Hui Geng   Yuan-Ping Ruan   Ai-E Wang  

    Graphical abstract Abstract We report a procedure—economical method for the highly enantioselective and protecting-group free total syntheses of nonpeptidal CCK antagonists asperlicins C and E. Starting from l -tryptophan, the synthesis of asperlicin C has been achieved in three steps, which features the low-valent titanium (LVT: TiCl 4 –Zn combination)-mediated reductive cyclization of o -nitrobenzamide to construct the (3 H )-quinazolin-4-one moiety. This is the first employment of LVT for the synthesis of asperlicin C, which allowed accessing asperlicin C in >99% enantioselectivity. Asperlicin C was converted, in one-pot, into asperlicin E and 2,3-di- epi -asperlicin E by dimethyl dioxirane (DMDO)-mediated tandem reactions. The use of DMDO as a green, cheap, and easily available oxidant to replace the photochemical method renders the synthesis of asperlicin E experimentally convenient.
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  • Procedure—economical enantioselective total syntheses of asperlicins C and E

    Huang, Pei-Qiang   Wang, Yu   Luo, Shi-Peng   Geng, Hui   Ruan, Yuan-Ping   Wang, Ai-E  

    We report a procedure economical method for the highly enantioselective and protecting-group free total syntheses of nonpeptidal CCK antagonists asperlicins C and E. Starting from L-tryptophan, the synthesis of asperlicin C has been achieved in three steps, which features the low-valent titanium (LVT: TiCl4-Zn combination)-mediated reductive cyclization of o-nitrobenzamide to construct the (3H)-quinazolin-4-one moiety. This is the first employment of LVT for the synthesis of asperlicin C, which allowed accessing asperlicin C in >99% enantioselectivity. Asperlicin C was converted, in one-pot, into asperlicin E and 2,3-di-epi-asperlicin E by dimethyl dioxirane (DMDO)-mediated tandem reactions. The use of DMDO as a green, cheap, and easily available oxidant to replace the photochemical method renders the synthesis of asperlicin E experimentally convenient. (C) 2015 Elsevier Ltd. All rights reserved.
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