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Now showing items 33 - 48 of 77

  • Coronary spasm reflects inputs from adjacent esophageal system

    Manfrini, O   Bazzocchi, G   Luati, A   Borghi, A   Monari, P   Bugiardini, R  

    Mechanisms underlying coronary spasm are still poorly understood. The aim of the study was to assess the hypothesis that fluctuations in the development of coronary spasm might reflect inputs from the adjacent esophageal system. We enrolled patients admitted to the coronary care unit for episodes of nocturnal angina. Seven patients with variant angina and five with coronary artery disease (CAD) had concurrent ECG and esophageal manometric monitoring. ECG monitoring documented 28 episodes of ST elevation in variant angina patients and 16 episodes of ST depression in CAD patients. Manometric analysis showed that esophageal spasms resulted remarkably more frequently in variant angina patients (143 total spasms; individual range 9-31) than in CAD patients (20 total spasms; individual range 0-9; P < 0.01). Time series analysis was used to assess fluctuations in the occurrence of abnormal esophageal waves and its relationship with spontaneous episodes of ST shift. Episodes of esophageal spasm in CAD were sporadic (<1 in 30 min) and not related to ECG-recorded ischemia. In the variant angina group, esophageal spasms were time related to ischemia (>1 into 5 min before ECG-recorded ischemia) (P < 0.05). A bidirectional analysis of causal effects showed that the influence processes between esophageal and coronary spasms were mutual and reciprocal (transfer function model, P < 0.05) in variant angina. We concluded that in variant angina patients, episodes of esophageal spasms and myocardial ischemia influenced each other. Mechanisms that cause esophageal spasm can feed back to produce coronary spasm. Coronary spasm may feed forward to produce additional episodes of esophageal spasm.
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  • Pyoderma gangrenosum and its syndromic forms: evidence for a link with autoinflammation.

    Marzano, A V   Borghi, A   Meroni, P L   Cugno, M  

    Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells. In PAPA syndrome, different mutations involving the PSTPIP1 gene, via an increased binding affinity to pyrin, induce the assembly of inflammasomes. These are molecular platforms involved in the activation of caspase 1, a protease that cleaves inactive prointerleukin (pro-IL)-1beta to its active isoform IL-1beta. The overproduction of IL-1beta triggers the release of a number of proinflammatory cytokines and chemokines, which are responsible for the recruitment and activation of neutrophils, leading to neutrophil-mediated inflammation. In SAPHO syndrome, the activation of the PSTPIP2 inflammasome has been suggested to play a role in inducing the dysfunction of the innate immune system. Patients with PASH have recently been reported to present alterations of genes involved in well-known autoinflammatory diseases, such as PSTPIP1, MEFV, NOD2 and NLRP3. Pyoderma gangrenosum and its syndromic forms can be regarded as a single clinicopathological spectrum in the context of autoinflammation. =C2=A9 2016 British Association of Dermatologists.
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  • A mineralogical application of micro-PIXE technique: Yttrium zoning in garnet from metamorphic rocks and its petrologic meaning

    Borghi, A   Cossio, R   Mazzoli, C  

    Micro-PIXE has been applied to a specific petrologic problem particularly affected by the limitation of other techniques. Selected garnet crystals from metapelitic rock samples equilibrated under high pressure low temperature metamorphic conditions coming from Western Alps were analysed. The yttrium concentration reveals a strongly (two order of magnitude) zoned distribution decreasing from core to rim in garnet crystals. Quantitative spot analyses range from about 1500 ppm at the core to 50 ppm at the rim, The extremely precise (LOD < 5 ppm) Y content determination by micro-PIXE technique allowed to better define the thermal rock history, applying a recently calibrated geothermometer. (C) 2002 Elsevier Science B.V. All rights reserved.
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  • Body water distribution and disease

    Bedogni, G   Borghi, A   Battistini, N  

    The study of body water distribution between extra- and intra-cellular spaces has the potential to improve our knowledge on the mechanisms of disease. A major challenge is that of establishing whether commonly detected subclinical alterations of body water distribution have prognostic or clinical implications.
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  • Il Pensiero Americano Contemporaneo: Filosofia, Epistemologia, Logicaby Feruccio Rossi-Landi; F. Barone; L. Borghi; G. Dorfles; P. Rossi; F. Rossi-Landi; U. Scarpelli; V. Somenzi; G. Vaccarino; A. Visalberghi;Il Pensiero Americano Contemporaneo: Scienze Socialiby F. Barbano; M. Calamandrei; R. Canestrari; A. Marzi; A. Giuliani; B. Griziotti; J. Griziotti-Kretschmann; L. Saffirio; G. Sartori

    Review by: Philip Ginnetti  

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  • Ugo Teodori: Problemi di genetica medica in campo endocrinologico, con la coll. U. di Bigozzi, A. Borghi, G. Giusti, F. Morabito, G.G. Relaz Neri-Serneri. VII Congresso Nazionale Endocrinologia, Firenze, 1957.

    Andreani, D.  

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  • Postseismic deformation following the 1997 Umbria-Marche (Italy) moderate normal faulting earthquakes

    Aoudia, A   Borghi, A   Riva, R   Barzaghi, R   Ambrosius, BAC   Sabadini, R   Vermeersen, LLA   Panza, GF  

    [1] We combine aftershock strain mapping, GPS measurements and leveling profiles with forward modeling of viscoelastic relaxation to study the postseismic deformation of the 1997 Umbria-Marche (Central Apennines) earthquake sequence. We explore the feasibility of GPS monitoring of postseismic transients, for the first time in Italy, generated by shallow and moderate sources. Our data allow us to distinguish a preferred coseismic faulting model as well as insight into the rheology of the Central Apennines Earth's crust. The faulting model requires a listric geometry with most of the energy released in the lower half part of the elastic crust. The rheological model consists of an elastic thin upper crust, a transition zone of about 10(18) Pa s underlain by a low-viscosity lower crust, ranging from 10(17) to 10(18) Pa s. The postseismic deformation is, both distributed in the transition zone-lower crust and confined to the fault zone.
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  • Growing evidence for topical mometasone fuoroate in the treatment of Vulvar Lichen Sclerosus.

    Virgili, A   Corazza, M   Minghetti, S   Borghi, A  

    Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. On the basis of the immunologic changes in VLS, treatment with a high potency topical corticosteroid is recommended. The currently available guidelines identified the ultra-potent corticosteroid clobetasol propionate 0.05% (CP) as the first-line recommended treatment but growing evidence supports the use of the potent corticosteroid mometasone furoate 0.1% (MMF). We reviewed the available studies assessing MMF in the treatment of VLS. Both non comparative and comparative studies were included in this review. Findings from clinical trials indicate that MMF is an effective and safe option in the treatment of VLS both in the active phase and in long-term maintenance treatment. Consistent with the findings from the comparative studies, MMF shows similar efficacy and safety to CP. Copyright =C2=A9 2014 Elsevier Ireland Ltd. All rights reserved.
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  • Comparative study on topical immunomodulatory and anti-inflammatory treatments for plasma cell vulvitis: long-term efficacy and safety.

    Virgili, A   Borghi, A   Minghetti, S   Corazza, M  

    BACKGROUND: Evidence on the treatment of plasma cell vulvitis (PCV) is scarce and comparative studies are lacking.; OBJECTIVE: To assess and compare the effectiveness and safety, on a long-term basis, of three topical interventions for the treatment of PCV.; METHODS: Retrospectively collected efficacy and safety data of a cohort of PCV patients treated with fusidic acid 2% and betamethasone valerate 0.1% cream fixed combination (FA/BM, 14 patients), clobetasol propionate 0.05% ointment (CP, six patients) and tacrolimus 0.1% ointment (TC, four patients) at different regimens between January 2000 and June 2013 were analysed. Treatment outcome was assessed according to Investigator Global Assessment (i) symptoms and (ii) signs, at 12, 24 and 52weeks.; RESULTS: After 12weeks, 85% of all patients achieved satisfactory improvement in PCV-related symptoms and maintained the improvement across a 52-week observation period. About 45% achieved a satisfactory result in clinical signs after 12weeks, without further improvement during the following 9months. No statistical differences in response were found among treatment groups at 12, 24 and 52weeks. All study treatments were significantly more effective in improving PCV symptoms rather than clinical signs. With regard to treatment tolerability, one patient (7.1%) in FA/BM group and one (25%) in TC group discontinued the treatment due to local side-effects.; CONCLUSIONS: CP, FA/BM and TC are effective and safe in treating PCV, inducing both a rapid improvement of the disease, notably of symptoms, and stabilizing its control. =C2=A9 2014 European Academy of Dermatology and Venereology.
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  • Comparison between major and trace element concentrations in garnet performed by EPMA and micro-PIXE techniques

    Vaggelli, G   Borghi, A   Cossio, R   Mazzoli, C   Olmi, F  

    This paper deals with the application of the electron and proton microprobe (EPMA and micro-PIXE) in order to determine major and trace elements in metamorphic garnet samples. The selected garnet samples come from a metapelitic rock belonging to the tectonic unit of Monte Rosa Nappe (Italy). Quantitative spot analysis profiles and compositional X-ray maps of both major and trace (yttrium) elements are reported. Major elements show a smoothed and continuous compositional zoning characterized by concentric variations from core to rim. Yttrium displays a strong enrichment in the core and a flat pattern at the rim. No correlation is shown between major and yttrium. distribution. Only a rough correlation may be supposed with manganese. A good agreement was found between EPMA and micro-PIXE yttrium. data, for values higher than 80-100 ppm. For lower values micro-PIXE technique is strongly recommended. The combination of X-ray two-dimensional maps and quantitative microanalyses allowed to evaluate the distribution of major and trace elements in a petrologically significative rock-forming mineral, to define the type of the chemical zoning and finally to attest difference in diffusivity between major and trace elements. Because of the slow diffusivity of yttrium, its quantitative determination in garnets is fundamental to reconstruct the temperature path suffered by polymetamorphic garnet-bearing rocks. (C) 2003 Elsevier Science B.V. All rights reserved.
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  • Sezione III civile; sentenza 7 giugno 1974, n. 1718; Pres. La Farina, Est. Auriti, P. M. Minetti (concl. conf.); Santoro (Avv. A. Tabet, Borghi) c. Micca (Avv. G. Fanelli, Morelli). Conferma Conciliatore Asti 29 dicembre 1971

    Michele Annunziata  

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  • Language as a source of abstract concepts Comment on "Words as social tools:Language,sociality and inner grounding in abstract concepts" by Anna M. Borghi et al.

    Lupyan, Gary  

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  • Surgical treatment of arrhythmias related to congenital heart diseases

    Vignati, G   Crupi, G   Vanini, V   Iorio, FS   Borghi, A   Giusti, S  

    Background. Supraventricular arrhythmias complicate operated and unoperated congenital heart disease, especially when atrial dilatation coexists. Methods. We evaluated the results of intraoperative ablation in a group of 23 patients with chronic supraventricular tachyarrhythmias (mostly intraatrial reentry) that were unresponsive to conventional medical therapy. All procedures were performed consecutively between September 1999 and November 2001. Ablation was done during redo operations (Fontan conversion to total cavopulmonary connection in 16 patients) in 18 patients and during primary surgical correction in 5 patients. The mean age at operation was 25 +/- 12 years (2 to 50 years). Cryoablation was done in 10 patients and radiofrequency ablation in 13 patients. Nineteen patients had ablation in one atrium and 4 had ablation in both atria. A generous atrial reduction was always performed at the end of the operation. Results. The operative mortality rate was 13% (3 patients) from causes unrelated to ablation. In 20 survivors, the ablation was effective immediately. Eight patients required a permanent pacemaker. During a mean follow-up of 22 4 months, atrial arrhythmias recurred in 25% (5 patients) and were controlled with medical therapy, whereas 1 patient required pacemaker implantation. Conclusions. Intraoperative treatment of unresponsive atrial tachyarrhythmias associated with operated or unoperated congenital heart disease is feasible and the midterm results are encouraging. (C) 2003 by The Society of Thoracic Surgeons.
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