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Now showing items 1 - 7 of 7

  • Kinematic evolution of the eastern Tethyan Himalaya: constraints from magnetic fabric and structural properties of the Triassic flysch in SE Tibet

    Antolin, B.   Appel, E.   Montomoli, C.   Dunkl, I.   Ding, L.   Gloaguen, R.   El Bay, R.  

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  • Combining nuchal translucency with umbilical Doppler velocimetry for detecting fetal trisomies in the first trimester of pregnancy: Martinez Crespo J.M.; Borrell A.; Antolin E.; Puerto B.; Casals E.; Ojuel J.; Fortuny A. ESP Br. J. Obstet. Gynaecol. 1997 104/1 (11–14)

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  • Metamorphic evolution of the Tethyan Himalayan flysch in SE Tibet

    Dunkl, I.   Antolin, B.   Wemmer, K.   Rantitsch, G.   Kienast, M.   Montomoli, C.   Ding, L.   Carosi, R.   Appel, E.   El Bay, R.   Xu, Q.   Von Eynatten, H.  

    The metamorphic conditions and the age of thermal overprint were determined in metapelites, metaarenites and metabasites of the Tethyan Himalayan Sequence (THS) in SE Tibet using Kubler Index and vitrinite reflectance data and applying thermobarometrical (Thermocalc and PERPLEX) and geochronological methods (illite/muscovite K-Ar and zircon and apatite (U-Th)/ He chronology). The multiple folded thrust pile experienced a thermal overprint reaching locally peak conditions between the diagenetic stage (c. 170 degrees C) and the amphibolite facies (c. 600 degrees C at 10 kbar). Burial diagenesis and heating due to Early Cretaceous dyke emplacement triggered the growth of illite in the metapelites. Eocene collision-related peak metamorphic conditions have been reached at c. 44 Ma. During collision the different tectonic blocks of the THS were tectonically buried to different structural levels so that they experienced maximum greenschist to amphibolite facies metamorphism. Later, during Oligocene to Miocene times the entire THS underwent anchi- to epizonal metamorphic conditions, probably associated to continuous deformation in the flysch fold-thrust-system. This period terminated at c. 24-22 Ma. Adjacent to the north Himalayan metamorphic domes, the base of the THS was metamorphosed during Miocene times (c. 13 Ma). Post-metamorphic cooling below c. 180 degrees C lasted until Late Miocene and took place at different times.
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  • Real-world short-term effectiveness of ustekinumab in Crohn's disease:Results from the ENEIDA Registry

    Iborra, M.   Beltran, B.   Fernandez, A.   Gutierrez, A.   Antolin, B.   Huguet, J. M.   de Francisco, R.   Merino, O.   Carpio, D.   Garcia Lopez, S.   Mesonero, F.   Minguez, M.   Ferreiro, R.   Carbajo, A. Y.   Rivero, M.   Chaparro, M.   Pinero-Perez, M. C.   Monfort i Miquel, D.   Bujanda, L.   Garcia-Sepulcre, M. F.   Martin-Cardona, A.   Canete, F.   Taxonera, C.   Sierra-Ausin, M.   Ferrer-Rosique, J. A.   Martin-Arranz, D.   Gonzalez-Munosa, C.   Mancenido-Marcos, N.   Rodriguez-Lago, I.   Iglesias-Flores, E.   Fores-Bosch, A.   Navarro-Llavat, M.   Calafat, M.   Madrigal-Dominguez, R. E.   Ramos, L.   Arroyo, M.   Busquets, D.   Lorente, R.   Saiz-Arnau, E.   Hernandez-Camba, A.   Jair-Morales, V.   Paredes, C.   Van Domselaar, M.   Hervas, D.   Canada-Martinez, A.   Nos, P.  

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  • Indication for clockwise rotation in the Siang window south of the eastern Himalayan syntaxis and new geochronological constraints for the area

    Liebke, Ursina   Antolin, B.   Appel, E.   Basavaiah, N.   Mikes, T.   Dunkl, I.   Wemmer, K.  

    Palaeomagnetic, rock magnetic and geochronological investigations were carried out on the Abor volcanics of Arunachal Pradesh, NE India. A Late Palaeozoic formation age for part of the Abor volcanics cannot be excluded based on K-Ar whole rock dating. Low-temperature thermochronometers - zircon (U-Th)/He and fission track analyses - yield a maximum burial temperature of c. 150-170 degrees C during Late Miocene. ZFT thermochronology of the Yinkiong and Miri Fms. indicates a post-Paleocene and post-Jurassic deposition age, respectively. This infers that the volcanic rocks intercalating or intruding them are not part of the Late Palaeozoic sequence but represent one or more, latest Cretaceous to Tertiary event(s). Therefore the Abor volcanics are connected to at least two separate events of volcanism. From palaeomagnetic sites, two characteristic magnetic remanence components were separated: a low-coercivity-component demagnetized below 20 mT and a high-coercivity-component demagnetized between 15 and 100 mT. Fold tests support a secondary origin of both components. Thermochronological and rock magnetic analyses indicate a low-grade overprint event between India-Asia collision and Miocene, which probably represents the time of remanence acquisition. The high-coercivity-component shows a trend of clockwise declinations, which is likely related to vertical-axis rotations of the eastern Himalayas due to eastward extrusion of the Tibetan Plateau.
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  • Combining nuchal translucency with umbilical Doppler velocimetry for detecting fetal trisomies in the first trimester of pregnancy: Martinez Crespo J.M.; Borrell A.; Antolin E.; Puerto B.; Casals E.; Ojuel J.; Fortuny A. ESP Br. J. Obstet. Gynaecol. 1997 104/1 (11–14)

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  • Real-world short-term effectiveness of ustekinumab in 305 patients with Crohn's disease:results from the ENEIDA registry

    Iborra, M.   Beltran, B.   Fernandez-Clotet, A.   Gutierrez, A.   Antolin, B.   Huguet, J. M.   De Francisco, R.   Merino, O.   Carpio, D.   Garcia-Lopez, S.   Mesonero, F.   Navarro, P.   Ferreiro-Iglesias, R.   Carbajo, A. Y.   Rivero, M.   Gisbert, J. P.   Pinero-Perez, M. C.   Monfort, D.   Bujanda, L.   Garcia-Sepulcre, M. F.   Martin-Cardona, A.   Canete, F.   Taxonera, C.   Domenech, E.   Nos, P.   Sierra-Ausin, M.   Ferrer-Rosique, J. A.   Martin-Arranz, M. D.   Gonzalez-Munoza, C.   Mancenido, N.   Rodriguez-Lago, I.   Benitez, J. M.   Fores-Bosch, A.   Navarro-Llavat, M.   Calafat, M.   Madrigal-Dominguez, R. E.   Ramos, L.   Arroyo, M.   Busquets, D.   Lorente, R.   Sainz-Arnau, E.   Hernandez-Camba, A.   Morales-Alvarado, V. J.   Paredes, J. M.   Van Domselaar, M.   Hervas, D.   Canada-Martinez, A.   Castro-Poceiro, J.   Cameo-Lorenzo, J.   Fernandez-Salazar, L.   Riestra, S.   Casas-Deza, D.   Tosca, J.   Barrio, J.   Garcia, M. J.   Chaparro, M.  

    Background There are limited data of ustekinumab administered according to the doses recommended in the UNITI studies. Aim To assess the real-world, short-term effectiveness of ustekinumab in refractory Crohn's disease (CD) Methods Multicentre study of CD patients starting ustekinumab after June 2017 at the recommend dose (260, 390 or 520 mg based on weight ~6 mg/kg IV week 0 and 90 mg subcutaneously week 8). Values for Harvey-Bradshaw Index (HBI), C-reactive protein (CRP) and faecal calprotectin (FC) were recorded at baseline and at weeks 8 and 14. Demographic and clinical data, previous treatments, AEs and hospitalisations were documented. Possible predictors of clinical remission were examined. Results Three hundred and five patients were analysed (>=3D 2 previous anti-TNF alpha therapies 64% and vedolizumab 29%). At baseline, 217 (72%) had an HBI >4 points. Of these, 101 (47%) and 126 (58%) achieved clinical remission at weeks 8 and 14, respectively. FC levels returned to normal (<250 mu g/g) in 46% and 54% of the patients at weeks 8 and 14 respectively. CRP returned to normal (<3 mg/L) in the 35% and 41% of the patients at week 8 and 14 respectively. AEs were recorded in 38, and 40 patients were hospitalised. Intolerance to the most recent anti-TNF agent and fewer previous anti-TNF agents were associated with clinical remission at week 14. Endoscopic severity was associated with poor response. Conclusion This is the first study to show the real-world effectiveness and safety of ustekinumab administered according to the recommended induction regimen in a cohort of highly refractory CD patients.
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