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Now showing items 1 - 7 of 7

  • Does Land Tenure Systems Affect Sustainable Agricultural Development?

    Akram, Nida   Akram, Muhammad Waqar   Wang, Hongshu   Mehmood, Ayesha  

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  • Research on Community Participation in Environmental Management of Ecotourism

    Wang, Hongshu   Tong, Min  

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  • Study on the Eco-tourism Environment Protection Based on the External Theory

    Wang, Hongshu   Shao, Shunyi  

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  • Optimisation algorithms for spatially constrained forest planning

    Han, Shijie   Zhao, Xiuhai   Nelson, John D.   Wang, Hongshu   Wang, Weiying  

    We compared genetic algorithms, simulated annealing and hill climbing algorithms on spatially constrained, integrated forest planning problems. There has been growing interest in algorithms that mimic natural processes, such as genetic algorithms and simulated annealing. These algorithms use random moves to generate new solutions, and employ a probabilistic acceptance/rejection criterion that allows inferior moves within the search space. Algorithms for a genetic algorithm, simulated annealing, and random hill climbing are formulated and tested on a same-sample forest-planning problem where the adjacency rule is strictly enforced. Each method was randomly started 20 times and allowed to run for 10,000 iterations. All three algorithms identified good solutions (within 3% of the highest found), however, simulated annealing consistently produced superior solutions. Simulated annealing and random hill climbing were approximately 10 times faster than the genetic algorithm because only one solution needs to be modified at each iteration. Performance of simulated annealing was essentially independent of the starting point, giving it an important advantage over random hill climbing. The genetic algorithm was not well suited to the strict adjacency problem because considerable computation time was necessary to repair the damage caused during crossover. (c) 2005 Elsevier B.V. All rights reserved.
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  • Establishing an Evaluation System and Limb-Salvage Protocol for Mangled Lower Extremities in China

    Lu, Shengdi   Han, Pei   Wen, Gen   Wang, Chunyang   Wang, Yanmao   Zhong, Wanrun   Wang, Hongshu   Chai, Yimin  

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  • Fisetin Inhibits Listeria monocytogenes Virulence by Interfering With the Oligomerization of Listeriolysin O

    Wang, Jianfeng   Qiu, Jiazhang   Tan, Wei   Zhang, Yu   Wang, Hongshu   Zhou, Xuan   Liu, Shui   Feng, Haihua   Li, Wenhua   Niu, Xiaodi   Deng, Xuming  

    Listeriolysin O (LLO), an essential virulence determinant of Listeria monocytogenes, is a pore-forming toxin whose primary function is to facilitate cytosolic bacterial replication by breaching the phagosomal membranes, which is critical for the pathogen to evade host immune recognition. The critical role of LLO in the virulence of L. monocytogenes renders it an ideal target for designing novel antivirulence therapeutics. We found that fisetin, a natural flavonoid without antimicrobial activity, is a potent antagonist of LLO-mediated hemolysis. Fisetin effectively inhibits L. monocytogenes infection in both tissue culture and animal infection models. Molecular modeling and mutational analysis revealed that fisetin directly engages loop 2 and loop 3 of LLO, leading to the blockage of cholesterol binding and the reduction of its oligomerization, thus inhibiting its hemolytic activity. Our results establish fisetin as an effective antitoxin agent for LLO, which can be further developed into novel therapeutics against infections caused by L. monocytogenes.
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  • Potential application of submerged horizontal plate as a wave energy breakwater: A 2D study using the WCSPH method

    He, Ming   Gao, Xifeng   Xu, Wanhai   Ren, Bing   Wang, Hongshu  

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