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Now showing items 49 - 63 of 63

  • Preparation of alumina/aluminide coatings on molybdenum metal substrates, and protection performance evaluation utilizing a DZ40M superalloy casting test

    Zheng, Liwei   Liu, Enze   Zheng, Zhi   Ning, Likui   Tong, Jian   Tan, Zheng  

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  • Significant photoelectric conversion properties of multilayer films formed by a cationic zinc phthalocyanine complex and graphene oxide

    Zhang, Wei   Li, Guoqin   Fei, Xiaoying   Zhang, Yu   Tong, Jian   Song, Xi-Ming  

    A novel kind of multilayer films consisting of graphene oxide and a cationic zinc phthalocyanine complex (ImZnPc) were fabricated through an electrostatic layer-by-layer self-assembly technique and were characterized using UV-vis absorption spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. These multilayer films were not only homogeneously formed, but also the complex ImZnPc was absorbed on the surface of GO as a non-aggregative monomolecular film. Under visible light irradiation, these films exhibited significant cathodic photocurrent generation with good stability and reproducibility. Especially, the four-layer film exhibited a very large cathodic photocurrent density of 5.6 mu A cm(-2), which makes this novel hybrid thin film a potential material for photoelectric conversion.
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  • Selective separation of patchouli alcohol from the essential oil of Cablin potchouli by inclusion crystalline method

    Tong, Jian   Yuan, Lei   Guo, Fang   Wang, Zhong-Hua   Jin, Lan   Guo, Wen-Sheng  

    In this article, we have focused on the application of non-traditional separation approach, the hostguest inclusion method, into the separation of the active component patchouli alcohol from the essential oil of Cablin potchouli Herb. The host molecule 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol (A) was used to selectively recognise the guest molecule patchouli alcohol (B) in the essential oil of Pogostemon cablin (Blanco) Benth through two strong hydrogen bonding. The inclusion compound was structurally determined by the single crystal X-ray diffraction. The separation effect was examined by gas chromatography for the whole essential oil and the inclusion compound, showing that the inclusion crystalline method is simple, rapid and effective for the separation of patchouli alcohol from the essential oil of C. potchouli Herb.
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  • Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish

    Huang, Yujie   Jiang, Bin   Xia, Ying   Wang, Jin   Ji, Cheng   Tong, Jian   Chen, Tao   Jiang, Yan  

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  • Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors

    Qin, Fenju   Zhang, Jie   Zan, Linsen   Guo, Weiqiang   Wang, Jin   Chen, Lili   Cao, Yi   Shen, Ouxi   Tong, Jian  

    The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line and in C57BL/6J mice. In-vitro experiments demonstrated that melatonin treatment significantly reduced testosterone levels in cell culture medium (P < 0.05 or P < 0.01); and decreased intracellular cyclic adenosine monophospha accumulation (P < 0.05 or P < 0.01) and mRNA/protein expression of GATA-4, SF-1 (NR5A1), StAR, P450SCC (CYP11A1) and 3 beta-HSD (P < 0.05 or P < 0.01). These effects were blocked by N-acetyl-2-benzyltryptamin, a melatonin receptor antagonist. Similar effects of melatonin on testosterone production (P < 0.05 or P < 0.01) and down-regulation of transcription factors GATA-4 and SF-1 (P < 0.01) were also observed in mice treated with intratesticular injections of melatonin. Overall, the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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  • Circular RNA profiles in mouse lung tissue induced by radon

    Pei, Weiwei   Tao, Lijing   Zhang, Leshuai W.   Zhang, Shuyu   Cao, Jianping   Jiao, Yang   Tong, Jian   Nie, Jihua  

    Background: Radon is a known human lung carcinogen, whose underlying carcinogenic mechanism remains unclear. Recently, circular RNA (circRNA), a class of endogenous non-protein coding RNAs that contain a circular loop, was found to exhibit multiple biological effects. In this study, circRNA profiles in mouse lung tissues between control and radon exposure were analyzed. Methods: Six mice were exposed to radon at concentration of 100,000 Bq/m(3), 12 h/d, for up to cumulative doses of 60 working level months (WLM). H&E staining and immunohistochemistry of caspase-3 were used to detect the damages in lung tissue. The lung tissue of control and exposed group were selected for circRNA microarray study. The circRNA/microRNA interaction was analyzed by starBase prediction software. 5 highest expressing circRNAs were selected by real-time PCR to validate the consistency in mouse lung tissue exposed to radon. Results: Inflammatory reaction was found in mouse lung tissue exposed to radon, and caspase-3 expression was significantly increased. Microarray screening revealed 107 up-regulated and 83 down-regulated circRNAs, among which top 30 circRNAs with the highest fold changes were chosen for further analysis, with 5 microRNAs binding sites listed for each circRNA. Consistency of the top 5 circRNAs with the highest expressions were confirmed in mice exposed with 60WLM of radon. Conclusion: Mouse lung tissue was severely injured when exposed to radon through pathological diagnosis and immunohistochemical analysis. A series of differentially expressed circRNAs demonstrated that they may play an important role in pulmonary toxicity induced by radon.
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  • Study on solid-liquid phase equilibria in ionic liquid - 1. The solubility of alkali chloride (MCl) in ionic liquid EMISE

    Yang, Jia-Zhen   Wang, Bin   Zhang, Qing-Guo   Tong, Jian  

    This paper reports the solubility of alkali chloride MCl (M is Li, Na and K) in IL EMISE was measured in the temperature range of 293.15 K to 343.15 K. The relationship between solubility, m and temperature T may be expressed in an empiric formula: In(m/m)=A(1) +A(2) T-0/T+A(3)T/T-0, where m(0) is 1 mol/kg, T-0 is 1 K. The observed sequence of solubility is LiCl > NaCl > KCl. The fact implies that the less the radius of alkali ion, the greater is its solubility because little ion is easy to get into the interstices of IL EMISE. (c) 2006 Elsevier B.V. All rights reserved.
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  • Structure and inclusion property of supramolecular host framework [H-2 L1][XCl4], L1=N,N,N',N'-tetra-p-methoxybenzyl-ethylenediamine; X = Fe, Co, Pd

    Guo, Fang   Li, Hong-lin   Li, Lei   Yu, Hong-cui   Lu, Na   Tong, Jian  

    In this paper, we have used the hydrogen-bonding interactions, combining the designed diamine ligands and anionic metal chlorides, into the construction of a series of new pillar-layered supramolecular complexes. The flexible molecule N,N,N',N'-tetra-p-methoxybenzyl-ethylenediamine (L1) bearing doubly protonated H-bond donors, has been synthesized and reacted with the metal chlorides (such as [PdCl4](2-), [FeCl4](-) and [CoCl4](2-)) via weak C-H center dot center dot center dot Cl interactions, yielding crystal products [H-2 L1](2+)center dot Cl-center dot[FeCl4](-) (1), 0.5H(2)O aS, [H-2 L1](2+)center dot Cl-center dot 0.5[PdCl4](2-) (2) and [2-hydroxy naphthyl](1.5) aS, 2[H-2 L1](2+)center dot 2Cl(-)center dot[CoCl4](2-) (3). The 3-D networks are organic double layers formed by the self-assembly of the ligands through extensive hydrogen-bonding interactions (C-H center dot center dot center dot O or C-H center dot center dot center dot pi interactions) and further interconnected by [PdCl4](2-)/[FeCl4](-)/[CoCl4](2-) in a pillar fashion, constructing into pillar-layered networks with channels accessible to various guest molecules. The inclusion property of [H-2 L1][CoCl4] was studied, varieties of guest molecules, such as 2-hydroxy naphthyl, phenanthrene and hydroquinone, can be included in the framework.
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  • Role of NF-κB activation in mouse bone marrow stromal cells exposed to 900 MHz radiofrequency fields (RF)

    Zong, Lin   Gao, Zhen   Xie, Wen   Tong, Jian   Cao, Yi  

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  • Radon-induced proteomic profile of lung tissue in rats

    Xu, Nai-Yu   Zhang, Su-Ping   Nie, Ji-Hua   Li, Jian-Xiang   Tong, Jian  

    The aim of this study was to investigate the differential expression of proteins in lung of rats following long-term exposure to radon. The total proteins of lung tissue from Wistar rats exposed to radon for cumulative doses up to 100, 200, or 400 WLM (working level months) were isolated by two-dimensional electrophoresis (2-DE) and analyzed with ImageMaster 2D Platinum software. Comparison of the 2-DE images between the control and radon-exposed groups resulted in 14 upregulated and 9 downregulated protein spots, of which 15 were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF-MS). The simultaneous up-expressions of RAGE and S100A6 indicated that both proteins might be applied as biomarkers for lung injury induced by long-term radon exposure.
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  • Quantification of 1-aminopyrene in human urine after a controlled exposure to diesel exhaust

    Laumbach, Robert   Tong, Jian   Zhang, Lin   Ohman-Strickland, Pamela   Stern, Alan   Fiedler, Nancy   Kipen, Howard   Kelly-McNeil, Kathie   Lioy, Paul  

    Diesel exhaust (DE) is a significant source of air pollution that has been linked to respiratory and cardiovascular morbidity and mortality. Many components in DE, such as polycyclic aromatic hydrocarbons, are present in the environment from other sources. 1-Nitropyrene appears to be a more specific marker of DE exposure. 1-Nitropyrene is partially metabolized to 1-aminopyrene and excreted in urine. We developed a practical, sensitive method for measuring 1-aminopyrene in human urine using a HPLC-fluorescence technique. We measured 1-aminopyrene concentrations in spot urine samples collected prior to and during 24 h following the start of 1 h controlled exposures to DE (target concentration 300 mu g m(-3) as PM10) and clean air control. Time-weighted-average concentrations of urinary 1-aminopyrene were significantly greater following the DE exposure compared to the control (median 138.7 ng g(-1) creatinine vs. 21.7 ng g(-1) creatinine, p < 0.0001). Comparing DE to control exposures, we observed significant increases in 1-aminopyrine concentration from pre-exposure to either first post-exposure void or peak spot urine concentration following exposure (p = 0.027 and p = 0.0026, respectively). Large inter-individual variability, in both the concentration of urinary 1-aminopyrene and the time course of appearance in the urine following the standardized exposure to DE, suggests the need to explore subject variables that may affect conversion of inhaled 1-nitropyrene to urinary excretion of 1-aminopyrene.
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  • Role of the gene Phlda1 in fenvalerate-induced apoptosis and testicular damage in Sprague-Dawley rats

    Hong, Ting   Li, Ru   Sun, Lu-Lu   Xu, Jie   He, Meng-Ting   Wang, Wei   Yan, Rui   Tong, Jian   Zhang, Jie  

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  • Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells

    Wu, Jing   Ni, Yiping   Wang, Xiaojuan   Yang, Qianlei   Mao, Jiayuan   Tong, Jian   Zhang, Jie   An, Yan  

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  • Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/beta-catenin signal pathways

    Yue, Cong   Ji, Cheng   Zhang, Hang   Zhang, Leshuai W.   Tong, Jian   Jiang, Yan   Chen, Tao  

    Our previous observations indicated that extractable organic matter (EOM) from PM2.5 induced malformations in the heart of zebrafish embryos by activating AhR and inhibiting canonical Wnt/beta-catenin signal pathway. As a nutritional factor, folic acid (FA) is reported to prevent cardiac defects during embryo development. Hence, we hypothesize that FA may prevent PM2.5-induced heart defects by interfering with AhR and Wnt/beta-catenin signaling pathways. Our results showed that FA supplementation alleviated the EOM-induced heart defects in zebrafish embryos, and both AhR inhibitor CH223191 and Wnt activator CHIR99021 enhanced the protective efficiency of FA. Furthermore, FA supplementation attenuated the EOM-induced upregulation of AhR and its target genes including Cyp1a1, Cyp1b1, Ahrra, and Ahrrb. EROD assay confirmed that the EOM agonized Cyp1a1 activity was diminished by FA. The EOM-induced downregulation of b-catenin and its target genes including Nkx2.5, Axin2, Sox9b, and Cox2b were recovered or even overexpressed in embryos exposed to EOM plus FA. In conclusion, our study suggested that FA supplementation protected against PM2.5 cardiac development toxicity by targeting AhR and Wnt/beta-catenin signal pathways.
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  • Layered structures constructed by second-sphere coordination via N-H center dot center dot center dot Cl and C-H center dot center dot center dot Cl hydrogen bonding: synthesis and crystal structures of tribenzylamine and [MCl6] (M = Sn, Re, and Te)

    Guo, Fang   Lu, Na   Tong, Jian   Luan, Yu-Bo   Guo, Wen-Sheng  

    A series of second-sphere coordination complexes of tribenzylamine (L1) and [MCl6] (M = Sn, Re, Te) have been synthesized and characterized by spectroscopic techniques (IR, NMR) and single-crystal X-ray diffraction. The main driving force for the encapsulation of [MCl6] and recognition with L1 is the second-sphere coordination of metal halides by the amide protons of the ligand via hydrogen bonding (N-H center dot center dot center dot Cl-M and C-H center dot center dot center dot Cl-M); new layered structures are described. Thermal stability and irreversible behavior of second-sphere coordination complexes [L2] center dot 0.5[TeCl6]2- center dot HCl center dot (H3O)+ center dot 0.5H2O (L2 = N,N,N',N'-tetrabenzyl-ethylenediamine) in contact with water vapor are also described.
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