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Now showing items 1 - 16 of 52

  • Evaluation of Spatial Balance of China's Regional Development

    Shen, Hongyan   Teng, Fei   Song, Jinping  

    China's substantial economic growth and rapid urbanization has brought about some negative effects, one of which is spatial imbalance. Spatial imbalance has attracted considerable attention from both the government and researchers, since it has severely hindered regional sustainable development. This study, from the perspective of the matching relationship between spatial supply capacity and development demand intensity, evaluates the spatial balance of 290 prefecture-level cities in China by establishing an index system that considers the economy, society, resources, and the environment. The findings of this study have demonstrated that the strategies and measures of China in the last few years have brought about a spatial imbalance in regional development while rapidly boosting economic growth. The results reveal that there is not a corresponding relationship between spatial supply capacity and development demand intensity in China's regional development, indicating that most cities in China are in an imbalanced state regarding regional development. Only a few cities have reached spatial balance, while overexploitation is a common phenomenon. This study displays an overall perspective on the state of spatial balance in China, providing a sound basis for implementing pertinent governance measures in different regions.
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  • TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

    Li, Jianwei   Liu, Caizhi   Li, Yuheng   Zheng, Qiaoxia   Xu, Youjia   Liu, Beibei   Sun, Weijia   Li, Yuan   Ji, Shuhui   Liu, Mingwei   Zhang, Jing   Zhao, Dingsheng   Du, Ruikai   Liu, Zizhong   Zhong, Guohui   Sun, Cuiwei   Wang, Yanqing   Song, Jinping   Zhang, Shu   Qin, Jun   Ling, Shukuan   Wang, Xianhua   Li, Yingxian  

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  • TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.

    Li, Jianwei   Liu, Caizhi   Li, Yuheng   Zheng, Qiaoxia   Xu, Youjia   Liu, Beibei   Sun, Weijia   Li, Yuan   Ji, Shuhui   Liu, Mingwei   Zhang, Jing   Zhao, Dingsheng   Du, Ruikai   Liu, Zizhong   Zhong, Guohui   Sun, Cuiwei   Wang, Yanqing   Song, Jinping   Zhang, Shu   Qin, Jun   Ling, Shukuan   Wang, Xianhua   Li, Yingxian  

    Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca2+ leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis mediated by local Ca2+/CaMKII signaling in osteoblasts. TMCO1 levels were significantly decreased in bone from both osteoporosis patients and bone-loss mouse models. Tmco1-/- mice exhibited loss of bone mass and altered microarchitecture characteristic of osteoporosis. In the absence of TMCO1, decreased HDAC4 phosphorylation resulted in nuclear enrichment of HADC4, which leads to deacetylation and degradation of RUNX2, the master regulator of osteogenesis. We further demonstrate that TMCO1-mediated Ca2+ leak provides local Ca2+ signals to activate the CaMKII-HDAC4-RUNX2 signaling axis. The establishment of TMCO1 as a pivotal player in osteogenesis uncovers a novel potential therapeutic target for ameliorating osteoporosis.=20
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  • Economic growth and pollutant emissions in China: a spatial econometric analysis

    Li, Qian   Song, Jinping   Wang, Enru   Hu, Hao   Zhang, Jianhui   Wang, Yeyao  

    This paper studies the emissions of SO2 and COD in China using fine-scale, countylevel data. Using a widely used spatial autocorrelation index, Moran's I statistics, we first estimate the spatial autocorrelations of SO2 and COD emissions. Distinct patterns of spatial concentration are identified. To investigate the driving forces of emissions, we then use spatial econometric models, including a spatial error model (SEM) and a spatial lag model (SLM), to evaluate the effects of variables that reflect level of economic development, population density, and industrial structure. Our results show that these explanatory variables are highly correlated with the level of SO2 and COD emissions, though their impacts on SO2 and COD vary. Compared to ordinary least square regression, the advantages of SLM and SEM are demonstrated as they effectively reveal the existence and significance of spatial dependence. The SEM, in particular, is chosen over the SLM as the role of spatial correlation is stronger in the error model than in the lag model. Based on the research results, we present some preliminary policy recommendations, especially for those high-high cluster regions that face significant environmental degradation and challenge.
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  • China’s Information and Communication Technology in Geographic Perspective

    Song, Jinping   Wang, Enru  

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  • XCT image reconstruction by a modified superiorized iteration and theoretical analysis

    Luo, Shousheng   Zhang, Yanchun   Zhou, Tie   Song, Jinping   Wang, Yanfei  

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  • The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss

    Xu, Zi   Sun, Weijia   Li, Yuheng   Ling, Shukuan   Zhao, Chenyang   Zhong, Guohui   Zhao, Dingsheng   Song, Jinping   Song, Hailin   Li, Jinqiao   You, Linhao   Nie, Guangjun   Chang, Yanzhong   Li, Yingxian  

    Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron deposition in both liver and bone was markedly increased in hindlimb unloaded mice, and was accompanied by the upregulation of osteoclast activity and downregulation of osteoblast activity. The iron chelator deferoxamine mesylate (DFO) reduced the iron content in bone and alleviated unloading-induced bone loss. The increased iron content in bone was mainly a result of the upregulation of transferrin receptor I (TfR1) and divalent metal transporter 1 with iron response element (DMT1 + IRE), rather than changes in the iron transporter ferroportin 1 (FPN1). The hepcidin level in the liver was significantly higher, while the FPN1 level in the duodenum was substantially reduced. However, there were no changes in the FPN1 level in bone tissue. During hindlimb unloading, downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss. In summary, these data show that unloading-induced bone loss was orchestrated by iron overload and coupled with the regulation of hepcidin by the liver. (C) 2016 Elsevier Inc. AIL rights reserved.
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  • Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity

    Sun, Huiyuan   Ling, Shukuan   Zhao, Dingsheng   Li, Yang   Zhong, Guohui   Guo, Ming   Li, Yuheng   Yang, Lin   Du, Jianpeng   Zhou, Yuezhang   Li, Jianwei   Liang, Shuai   Wang, Yanqing   Gao, Xingcheng   Zhang, Yating   Cao, Dengchao   Liu, Caizhi   Jin, Xiaoyan   Liu, Zizhong   Sun, Weijia   Wu, Xiaorui   Song, Jinping   Li, Yingxian   Shi, Dazhuo  

    Background: Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca2+ overload. However, whether PQS can ameliorate cardiac atrophy following exposure to simulated microgravity remains unknown. Purpose: To explore the protective role of PQS in cardiac remodeling under unloading conditions and its underlying mechanisms. Methods: Hindlimb unloading (HU) model was used to simulate unloading induced cardiac remodeling. Forty-eight male rats were randomly assigned to four groups, including control, PQS, HU and HU + PQS. At 8 weeks after the experiment, cardiac structure and function, serum levels of Creatine Kinase-MB (CK-MB), Cardiactroponin T (cTnT), ischemia modified albumin (IMA), and cardiomyocyte apoptosis were measured. Network pharmacology analysis was used to predict the targets of the six major constituents of PQS, and the signaling pathways they involved in were analyzed by bioinformatics methods. Changes in the key proteins involved in the protective effects of PQS were further confirmed by Western Blot. Results: Simulated microgravity led to increases in serum levels of CK-MB, cTnT and IMA, remodeling of cardiac structure, impairment of cardiac function, and increased cardiomyocyte apoptosis as compared with control. PQS treatment significantly reduced serum levels of CK-MB, cTnT and IMA, improved the impaired cardiac structure and function, and decreased cardiomyocyte apoptosis induced by unloading. The activation of AMPK and inhibition of Erk1/2 and CaMKII/HDAC4 were demonstrated in the cardiocytes of HU rats after PQS treatment. Conclusion: PQS provides protection against cardiac remodeling induced by simulated microgravity, partly resulting from changes in the signaling pathways related to energy metabolism reduction, calcium overloading and cell apoptosis.
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  • Protection of urban features during urbanization based on the roles of springs in Jinan

    Wang, Xueqin   Wang, Chengxin   Wang, Botao   Liu, Shenghe   Song, Jinping  

    Thirty-seven years since reform and opening up, China has sustained rapid economic growth and urbanization. However, there was inadequate protection of natural, historical, and cultural heritage, especially in the past 17 years, which led to the outcome that urban and rural construction lacked features. To rebuild our urban features during urbanization, and avoid destroying them, we should probe into the reason of lacking features and how to protect them. Therefore, taking Jinan City as an example, this paper explored the crisis and its causes of urban characteristics during the period of rapid urbanization based on discussing roles of spring features, including economic effects, social effects, ecological effects and so on. What is more, this paper listed and analyzed those protection measures taken by Jinan. The results showed that spring groups spewed again and kept for 8 years through those measures, which meant that urban characteristics restored. Thus, Jinan City provides successful and significant reference for other cities in restoring urban features during urbanization construction. Also, the author deemed that cities could recollect their urban features as long as they take reasonable measures.
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  • A General Strategy to Create RNA Aptamer Sensors Using “Regulated” Graphene Oxide Adsorption

    Song, Jinping   Lau, Pui Sai   Liu, Meng   Shuang, Shaomin   Dong, Chuan   Li, Yingfu  

    null
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  • A rapid and easy approach for the reduction of graphene oxide by formamidinesulfinic acid

    Ma, Qi   Song, Jinping   Jin, Chun   Li, Zuopeng   Liu, Jianhong   Meng, Shuangming   Zhao, Jianguo   Guo, Yong  

    A rapid and easy approach for synthesizing chemically reduced graphene oxide (CRGO) by using formamidinesulfinic acid (FAS) as a reducing agent is reported. The obtained CRGO nanosheets were characterized with Fourier transform infrared spectroscopy, UV-Vis absorption spectroscopy, Raman spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, atomic force microscopy and electrical conductivity. The possible reduction mechanism was proposed. The stronger reduction capacity of FAS was attributed to the synergistic effect of its hydrolysis products (HSO3- and urea) in alkaline aqueous media. (c) 2012 Elsevier Ltd. All rights reserved.
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  • Knockdown of CD44 inhibits the alteration of osteoclast function induced by simulated microgravity

    Li, Yuheng   Gao, Xingcheng   Ling, Shukuan   Zhong, Guohui   Sun, Weijia   Liu, Caizhi   Li, Jianwei   Song, Jinping   Zhao, Dingsheng   Jin, Xiaoyan   Li, Yingxian   Sun, Xi-Qing  

    Mechanical forces are essential to maintain skeletal homeostasis, and microgravity exposure leads to bone loss. During space flight, bone mineral density is decreased because of the inactivation of osteoblast and activation of osteoclast. However, the underlying molecular mechanism is still not clear. CD44 acts as a cellular surface adhesion molecule, which plays an important role in signal transduction between cells. Numerous studies have shown that CD44 plays diverse roles in promoting pre-osteoclast fusion. However, the role of CD44 in the alteration of osteoclast function induced by simulated microgravity remains to be fully elucidated. In this work, we utilized a ground-based, microgravity-simulation system, the Rotating Wall Vessel Bioreactor (RWVB). Using the RWVB, we demonstrated that simulated microgravity enhanced osteoclast function, meantime CD44 mRNA and protein levels were significantly increased. To verify the effects of CD44 on alteration of osteoclast function induced by simulated microgravity, specific siRNAs targeting CD44 were transfected. The results showed knockdown of CD44 inhibited the alteration of osteoclast function induced by simulated microgravity. Moreover, we found that clinorotation activated the NF-kappa B/NFATc1-mediated signaling pathway, which was downregulated after knockdown of CD44. Our study provided evidence that CD44 positively regulated osteoclast function and therapeutic suppression of CD44 may counteract bone loss induced by simulated microgravity.
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  • Knockdown of CD44 inhibits the alteration of osteoclast function induced by simulated microgravity

    Li, Yuheng   Gao, Xingcheng   Ling, Shukuan   Zhong, Guohui   Sun, Weijia   Liu, Caizhi   Li, Jianwei   Song, Jinping   Zhao, Dingsheng   Jin, Xiaoyan   Li, Yingxian   Sun, Xi-qing  

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  • Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity

    Liu, Caizhi   Zhong, Guohui   Zhou, Yuezhang   Yang, Yuchen   Tan, Yingjun   Li, Yuheng   Gao, Xingcheng   Sun, Weijia   Li, Jianwei   Jin, Xiaoyan   Cao, Dengchao   Yuan, Xinxin   Liu, Zizhong   Liang, Shuai   Li, Youyou   Du, Ruikai   Zhao, Yinlong   Xue, Jianqi   Zhao, Dingsheng   Song, Jinping   Ling, Shukuan   Li, Yingxian  

    Objectives Cardiac Ca2+ signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca2+ signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and 4G hypergravity. Materials and Methods The cardiomyocyte cell line HL-1 was used in this study. A clinostat and centrifuge were used to study the effects of microgravity and hypergravity, respectively, on cells. Calcium signalling was detected with laser scanning confocal microscopy. Protein and mRNA levels were detected by Western blotting and real-time PCR, respectively. Wheat germ agglutinin (WGA) staining was used to analyse cell size. Results Our data showed that spontaneous calcium oscillations and cytosolic calcium concentration are both increased in HL-1 cells after simulated microgravity and 4G hypergravity. Increased cytosolic calcium leads to activation of calmodulin-dependent protein kinase II/histone deacetylase 4 (CaMKII/HDAC4) signalling and upregulation of the foetal genes ANP and BNP, indicating cardiac remodelling. WGA staining indicated that cell size was decreased following rotation-simulated microgravity and increased following 4G hypergravity. Moreover, HL-1 cell proliferation was increased significantly under hypergravity but not rotation-simulated microgravity. Conclusions Our study demonstrates for the first time that Ca2+/CaMKII/HDAC4 signalling plays a pivotal role in myocardial remodelling under rotation-simulated microgravity and hypergravity.
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  • Spatial Distribution of Migration and Economic Development: A Case Study of Sichuan Province, China

    Yang, Chengfeng   Han, Huiran   Song, Jinping  

    The spatial distribution of China's rapid growth in population and economic development is uneven, and this imbalance leads to migration. However, the literature concerning migration in China has been primarily focused at the provincial scale and on eastern parts of the country. Relatively few studies have examined migration between counties and these rarely involve poor areas, and even more rarely involving out-migration areas. Using statistical data, this study analyzes the spatial correspondence between population distribution and economic development in Sichuan with an index, the Correspondence of Population and Economy (CPE). We also build a regression model of net-migration to analyze the driving forces of migration. The results include the following: (1) The distribution of population, population density, GDP, and GDP growth are all similar, and the high value areas are mainly concentrated in eastern Sichuan; (2) The number of counties that are balanced in CPE dropped from 30 to 12 from 2005 to 2012, but the counties did not overlap; (3) Most in-migrants come from Sichuan itself, and in-migration areas are primarily concentrated in cities; (4) In the regression model, the four economic factors have a positive influence on net-migration, but rural employment has a negative influence; (5) CPE has a weak negative correlation with net-migration.
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  • Spatial Distribution of Migration and Economic Development: A Case Study of Sichuan Province, China

    Yang, Chengfeng   Han, Huiran   Song, Jinping  

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